Adenosine A2B receptors: a novel therapeutic target in asthma?

Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor

1997 • 906 citations

Molecular cloning and characterization of an adenosine receptor: the A3 adenosine receptor.

1992 • 649 citations

The A3 adenosine receptor is the unique adenosine receptor which facilitates release of allergic mediators in mast cells

1993 • 445 citations

Adenosine A2B receptors.

1997 • 407 citations

Adenosine A2b receptors evoke interleukin-8 secretion in human mast cells. An enprofylline-sensitive mechanism with implications for asthma.

1995 • 364 citations

Neutrophil adherence to endothelium is enhanced via adenosine A1 receptors and inhibited via adenosine A2 receptors.

1992 • 361 citations

Pharmacology of adenosine A2A receptors

1996 • 321 citations

Adenosine in Bronchoalveolar Lavage Fluid in Asthma

1993 • 310 citations

5'-adenosine monophosphate is the neutrophil-derived paracrine factor that elicits chloride secretion from T84 intestinal epithelial cell monolayers.

1993 • 294 citations

Potentiation of Mast Cell Mediator Release by Adenosine

1978 • 273 citations

DNA antisense therapy for asthma in an animal model

1997 • 261 citations

Xanthine derivatives as adenosine receptor antagonists

1982 • 239 citations

Isolated Bronchi from Asthmatics Are Hyperresponsive to Adenosine, which Apparently Acts Indirectly by Liberation of Leukotrienes and Histamine

1992 • 226 citations

Differential activation of adenosine receptors decreases N-type but potentiates P-type Ca2+ current in hippocampal CA3 neurons

1993 • 212 citations

Canine Mast Cell Adenosine Receptors: Cloning and Expression of the A₃Receptor and Evidence that Degranulation Is Mediated by the A_2BReceptor

1997 • 206 citations

Molecular cloning and functional expression of a sheep A3 adenosine receptor with widespread tissue distribution.

1993 • 200 citations

The Contribution of Histamine to Immediate Bronchoconstriction Provoked by Inhaled Allergen and Adenosine 5′ Monophosphate in Atopic Asthma

1987 • 186 citations

Adenosine A3 receptor expression and function in eosinophils.

1997 • 165 citations

Regulation of human basophil and lung mast cell function by cyclic adenosine monophosphate.

1988 • 164 citations

Adenosine, methacholine, and exercise challenges in children with asthma or paediatric chronic obstructive pulmonary disease.

1995 • 162 citations

Airway effects of purine nucleosides and nucleotides and release with bronchial provocation in asthma

1986 • 160 citations

Adenosine release from stimulated mast cells.

1984 • 157 citations

Release of Mast-Cell-derived Mediators after Endobronchial Adenosine Challenge in Asthma

1995 • 156 citations

Effect of allergen avoidance at high altitude on direct and indirect bronchial hyperresponsiveness and markers of inflammation in children with allergic asthma.

1996 • 154 citations

Adenosine Potentiates Mediator Release from Human Lung Mast Cells

1988 • 148 citations

Functional characterization of the A2b adenosine receptor in NIH 3T3 fibroblasts

1994 • 140 citations

Cloning of two adenosine receptor subtypes from mouse bone marrow-derived mast cells.

1994 • 129 citations

Adenosine and Adenine Nucleotides: From Molecular Biology to Integrative Physiology

1995 • 129 citations

A role for mast cells in adenosine A³ receptor‐mediated hypotension in the rat

1995 • 128 citations

Effects of enprofylline and theophylline may show the role of adenosine

1986 • 113 citations

Greater Effect of Inhaled Budesonide on Adenosine 5′-Monophosphate-induced than on Sodium-Metabisulfite-induced Bronchoconstriction in Asthma

1992 • 112 citations

Adenosine promotes neutrophil chemotaxis.

1988 • 109 citations

Specific antagonism of adenosine‐induced bronchoconstriction in asthma by oral theophylline.

1985 • 108 citations

Airway Responsiveness to Adenosine 5′-Monophosphate in Chronic Obstructive Pulmonary Disease Is Determined by Smoking

1993 • 107 citations

Adenosine inhibits and potentiates IgE‐dependent histamine release from human basophils by an A₂‐receptor mediated mechanism

1983 • 105 citations

Adenosine bronchoprovocation: a promising marker of allergic inflammation in asthma?

1997 • 104 citations

Increased secretion of tumor necrosis factor-alpha, interleukin-1-beta, and interleukin-6 by alveolar macrophages from patients with sarcoidosis

1993 • 95 citations

Purines and neutrophil leukocytes

1997 • 94 citations

Effect of oral terfenadine on the bronchoconstrictor response to inhaled histamine and adenosine 5'-monophosphate in non-atopic asthma.

1987 • 87 citations

The Response of Plasma Histamine to Bronchoprovocation with Methacholine, Adenosine 5′-monophosphate, and Allergen in Atopic Nonasthmatic Subjects

1990 • 77 citations

An Animal Model for Adenosine-induced Bronchoconstriction

1987 • 76 citations

Molecular characterization of recombinant human adenosine receptors

1996 • 76 citations

Calcium mobilization in Jurkat cells via A_2b adenosine receptors

1997 • 70 citations

The effect of inhaled ipratropium bromide alone and in combination with oral terfenadine on bronchoconstriction provoked by adenosine 5′-monophosphate and histamine in asthma

1991 • 67 citations

Positive modulation of intracellular Ca2+ levels by adenosine A2b receptors, prostacyclin, and prostaglandin E1 via a cholera toxin-sensitive mechanism in human erythroleukemia cells.

1994 • 60 citations

Studies on the receptor mediating cyclic AMP‐independent enhancement by adenosine of IgE‐dependent mediator release from rat mast cells

1986 • 56 citations

Characterization of adenosine receptors in human erythroleukemia cells and platelets: further evidence for heterogeneity of adenosine A2 receptor subtypes.

1993 • 55 citations

Protective effects of inhaled ipratropium bromide on bronchoconstriction induced by adenosine and methacholine in asthma

1992 • 53 citations

Functional expression of adenosine A2b receptor in Xenopus oocytes.

1993 • 52 citations

In vivo role of the adenosine A3 receptor: N6-2-(4-aminophenyl)ethyladenosine induces bronchospasm in BDE rats by a neurally mediated mechanism involving cells resembling mast cells.

1996 • 50 citations

Pharmacology of adenosine A2A receptors

1996 • 50 citations

Apparent enhancement of cholinergic transmission in rabbit bronchi via adenosine A2 receptors

1986 • 47 citations

Effect of indomethacin on adenosine-induced bronchoconstriction

1989 • 46 citations

Repeated inhalation of bradykinin attenuates adenosine 5'-monophosphate (AMP) induced bronchoconstriction in asthmatic airways

1992 • 42 citations

The protective effects of intravenous theophylline and enprofylline against histamine- and Adenosine 5′-monophosphate-provoked bronchoconstriction: Implications for the mechanisms of action of xanthine derivatives in asthma

1989 • 40 citations

A [³H]amine congener of 1,3‐dipropyl‐8‐phenylxanthine

1986 • 37 citations

Enhancing effect of dipyridamole inhalation on adenosine‐induced bronchospasm in asthmatic patients

1988 • 35 citations

2‐Chloroadenosine induction of vagally‐mediated and atropine‐resistant bronchomotor responses in anaesthetized guinea‐pigs

1990 • 31 citations

Effects of enprofylline on A1 and A2 adenosine receptors

1985 • 31 citations

Inhaled lysine acetylsalicylate (L-ASA) attenuates the bronchoconstrictor response to adenosine 5'-monophosphate (AMP) in asthmatic subjects

1995 • 29 citations

Adenosine: a Positive Modulator of Airway Inflammation in Asthma

1991 • 26 citations

Comparative nasal effects of bradykinin and histamine: influence on nasal airways resistance and plasma protein exudation.

1993 • 25 citations

Absence of a late-phase response or increase in histamine responsiveness after bronchial provocation with adenosine 5′-monophosphate in atopic and non-atopic asthma

1988 • 23 citations

Adenosine causes transient dilatation of coronary arteries in man.

1987 • 23 citations

Inhibition of protein kinase A fails to alter mast cell adenosine responsiveness

1994 • 21 citations

Modulation of mast cell responses to adenosine by agents that alter protein kinase C activity

1990 • 16 citations

Mechanism of the effector function of adenosine in asthma and rhintis

1993 • 9 citations