Recent developments in selective agonists and antagonists acting at purine and pyrimidine receptors

Molecular cloning and characterization of an adenosine receptor: the A3 adenosine receptor.

1992 • 649 citations

Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential

1992 • 447 citations

Molecular cloning and characterization of the human A3 adenosine receptor.

1993 • 421 citations

4-Amino[1,2,4]triazolo[4,3-a]quinoxalines. A novel class of potent adenosine receptor antagonists and potential rapid-onset antidepressants

1990 • 400 citations

The in vitro pharmacology of ZM 241385, a potent, non‐xanthine, A_2a selective adenosine receptor antagonist

1995 • 361 citations

CGS 21680C, an A2 selective adenosine receptor agonist with preferential hypotensive activity.

1989 • 245 citations

P₂‐purinoceptors of two subtypes in the rabbit mesenteric artery: reactive blue 2 selectively inhibits responses mediated via the P_2y‐ but not the P_2x‐purinoceptor

1987 • 245 citations

A unifying purinergic hypothesis for the initiation of pain

1996 • 241 citations

Purinergic approaches in experimental therapeutics

1997 • 238 citations

Structure-Activity Relationships of N6-Benzyladenosine-5'-uronamides as A3-Selective Adenosine Agonists

1994 • 236 citations

2-Substitution of N6-Benzyladenosine-5'-uronamides Enhances Selectivity for A3 Adenosine Receptors

1994 • 197 citations

G PROTEIN-DEPENDENT ACTIVATION OF PHOSPHOLIPASE C BY ADENOSINE A3 RECEPTORS IN RAT BRAIN

1995 • 182 citations

125I-4-aminobenzyl-5'-N-methylcarboxamidoadenosine, a high affinity radioligand for the rat A3 adenosine receptor.

1994 • 172 citations

Activation of Hippocampal Adenosine A₃Receptors Produces a Desensitization of A₁Receptor-Mediated Responses in Rat Hippocampus

1997 • 171 citations

Induction of Apoptosis in HL-60 Human Promyelocytic Leukemia Cells by Adenosine A3Receptor Agonists

1996 • 170 citations

How should P2x purinoceptors be classified pharmacologically?

1995 • 163 citations

Structure-activity relationships of 8-styrylxanthines as A2-selective adenosine antagonists

1993 • 147 citations

Structure-activity profile of a series of novel triazoloquinazoline adenosine antagonists

1988 • 147 citations

Suramin analogues as subtype-selective G protein inhibitors.

1996 • 146 citations

Differential effects of P₂‐purinoceptor antagonists on phospholipase C‐ and adenylyl cyclase‐coupled P_2Y‐purinoceptors

1994 • 142 citations

(E)-1,3-Dialkyl-7-methyl-8-(3,4,5-trimethoxystyryl)xanthines: potent and selective adenosine A2 antagonists

1992 • 138 citations

Derivatives of the Triazoloquinazoline Adenosine Antagonist (CGS15943) Are Selective for the Human A₃Receptor Subtype

1996 • 132 citations

2-Chloro-N6-[3H]cyclopentyladenosine ([3HCCPA) ?a high affinity agonist radioligand for A1 adenosine receptors

1989 • 131 citations

A3-adenosine receptors: Design of selective ligands and therapeutic prospects

1995 • 125 citations

A2A adenosine receptors from rat striatum and rat pheochromocytoma PC12 cells: characterization with radioligand binding and by activation of adenylate cyclase.

1992 • 115 citations

Identification of potent, selective P2Y-purinoceptor agonists: structure-activity relationships for 2-thioether derivatives of adenosine 5'-triphosphate

1993 • 113 citations

Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine Derivatives: Potent and Selective A_2AAdenosine Antagonists

1996 • 109 citations

Synthesis and Biological Activities of Flavonoid Derivatives as A₃ Adenosine Receptor Antagonists

1996 • 107 citations

Interactions of Flavonoids and Other Phytochemicals with Adenosine Receptors

1996 • 105 citations

Structure activity relationships for derivatives of adenosine‐5′‐triphosphate as agonists at P₂ purinoceptors: Heterogeneity within P_2x and P_2y subtypes

1994 • 98 citations

Interaction of 1,4-Dihydropyridine and Pyridine Derivatives with Adenosine Receptors: Selectivity for A₃ Receptors

1996 • 95 citations

Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure

1992 • 91 citations

125I-4-(2-[7-amino-2-[2-furyl][1,2,4]triazolo[2,3-a][1,3,5] triazin-5-yl-amino]ethyl)phenol, a high affinity antagonist radioligand selective for the A2a adenosine receptor.

1995 • 88 citations

6-Phenyl-1,4-dihydropyridine Derivatives as Potent and Selective A₃ Adenosine Receptor Antagonists

1996 • 82 citations

N6-[2-(3,5-dimethoxyphenyl)-2-(2-methylphenyl)ethyl]adenosine and its uronamide derivatives. Novel adenosine agonists with both high affinity and high selectivity for the adenosine A2 receptor

1988 • 81 citations

Inhibitory action of PPADS on relaxant responses to adenine nucleotides or electrical field stimulation in guinea‐pig taenia coli and rat duodenum

1995 • 80 citations

Sustained activation of phospholipase D via adenosine A3 receptors is associated with enhancement of antigen- and Ca(2+)-ionophore-induced secretion in a rat mast cell line.

1996 • 75 citations

Enzymatic synthesis of UTP_γS, a potent hydrolysis resistant agonist of P_2U‐purinoceptors

1996 • 67 citations

N-Substituted Adenosines as Novel Neuroprotective A₁ Agonists with Diminished Hypotensive Effects

1999 • 66 citations

1H-Imidazo[4,5-c]quinolin-4-amines: novel non-xanthine adenosine antagonists

1991 • 60 citations

Selective A₁-Antagonists for Treatment of Cognitive Deficits

1991 • 58 citations

N⁶,C8-Disubstituted Adenosine Derivatives as Partial Agonists for Adenosine A₁ Receptors

1996 • 57 citations

Current Developments of A2a Adenosine Receptor Antagonists

1995 • 57 citations

Identification of potent P_2Y‐purinoceptor agonists that are derivatives of adenosine 5′‐monophosphate

1996 • 50 citations

Structure-Activity Relationships of 1,3-Dialkylxanthine Derivatives at Rat A3 Adenosine Receptors

1994 • 50 citations

2-Aralkynyl and 2-Heteroalkynyl Derivatives of Adenosine-5'-N-Ethyluronamide as Selective A2a Adenosine Receptor Agonists

1995 • 50 citations

N6,9-Disubstituted adenines: potent, selective antagonists at the A1 adenosine receptor

1991 • 46 citations

Synthesis and biological activity of N6-(p-sulfophenyl)alkyl and N6-sulfoalkyl derivatives of adenosine: water-soluble and peripherally selective adenosine agonists.

1992 • 45 citations

Differentiation by pyridoxal 5-phosphate, PPADS and IsoPPADS between responses mediated by UTP and those evoked by α,β-methylene-ATP on rat sympathetic ganglia

1995 • 44 citations

Potent agonist action of 2‐thioether derivatives of adenine nucleotides at adenylyl cyclase‐linked P_2y‐purinoceptors

1995 • 36 citations

NovelN⁶-(Substituted-phenylcarbamoyl)adenosine-5‘-uronamides as Potent Agonists for A₃Adenosine Receptors

1996 • 35 citations

Novel competitive antagonists for P2 purinoceptors

1994 • 33 citations

Survey of Nonxanthine Derivatives as Adenosine Receptor Ligands

1996 • 30 citations

Selective Ligands for Rat A3 Adenosine Receptors: Structure-Activity Relationships of 1,3-Dialkylxanthine 7-Riboside Derivatives

1994 • 29 citations

Tetrahydrobenzothiophenone Derivatives as a Novel Class of Adenosine Receptor Antagonists

1996 • 27 citations

1,3-Dipropyl-8-[2-(5,6-epoxy)norbornyl]xanthine, a potent, specific and selective A1 adenosine receptor antagonist in the guinea pig heart and brain and in DDT1MF-2 cells.

1995 • 26 citations

Comparative molecular field analysis of selective A3 adenosine receptor agonists

1995 • 25 citations

2-Alkenyl and 2-Alkyl Derivatives of Adenosine and Adenosine-5‘-N-Ethyluronamide: Different Affinity and Selectivity of E- and Z-Diastereomers at A_2A Adenosine Receptors

1996 • 24 citations

General pharmacology of SDZ WAG 994, a potent selective and orally active adenosine A₁ receptor agonist

1995 • 22 citations

Relative binding orientations of adenosine A1 receptor ligands — A test case for Distributed Multipole Analysis in medicinal chemistry

1995 • 19 citations

Structure Activity Relationships for Adenine Nucleotide Receptors on Mast Cells, Human Platelets, and Smooth Muscle

1990 • 13 citations

Induction of Apoptosis in HL-60 Human Promyelocytic Leukemia Cells by Adenosine A3Receptor Agonists

1996 • 3 citations