Thymic epithelial defects and predisposition to autoimmune disease in BB rats.

The Role of the T Cell Receptor in Positive and Negative Selection of Developing T Cells

1990 • 589 citations

Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+ T cell subset that inhibits this autoimmune potential.

1993 • 442 citations

The Spontaneously Diabetic Wistar Rat: Metabolic and Morphologic Studies

1977 • 409 citations

Clonal Deletion Versus Clonal Anergy: The Role of the Thymus in Inducing Self Tolerance

1990 • 380 citations

Self-Nonself Discrimination by T Cells

1990 • 331 citations

MRC OX‐19: A monoclonal antibody that labels rat T lymphocytes and augments in vitro proliferative responses

1984 • 305 citations

Suppression of adjuvant arthritis in Lewis rats by oral administration of type II collagen.

1990 • 229 citations

Depletion of RT6.1+ T lymphocytes induces diabetes in resistant biobreeding/Worcester (BB/W) rats.

1987 • 224 citations

Autoimmune diabetes mellitus in the BB rat

1992 • 223 citations

Genetic dissection of autoimmune type I diabetes in the BB rat

1992 • 218 citations

Neonatal Thymectomy Prevents Spontaneous Diabetes Mellitus in the BB/W Rat

1982 • 193 citations

The BB rat

1987 • 174 citations

Passive Transfer of Diabetes in the BB/W Rat

1983 • 155 citations

Spontaneous diabetes mellitus syndrome in the rat. I. Association with the major histocompatibility complex.

1981 • 155 citations

The BB Diabetic Rat: Profound T-Cell Lymphocytopenia

1981 • 153 citations

Identification of profound peripheral T lymphocyte immunodeficiencies in the spontaneously diabetic BB rat.

1983 • 152 citations

Thymus epithelium induces tissue-specific tolerance.

1993 • 111 citations

Influence of Environmental Viral Agents on Frequency and Tempo of Diabetes Mellitus in BB/Wor Rats

1991 • 102 citations

Adoptive transfer of autoimmune diabetes mellitus in biobreeding/Worcester (BB/W) inbred and hybrid rats.

1985 • 87 citations

Prevention of Diabetes in BB/Wor Rat by Single Transfusion of Spleen Cells: Parameters That Affect Degree of Protection

1989 • 83 citations

Poly I:C Accelerates Development of Diabetes Mellitus in Diabetes-Prone BB Rat

1992 • 81 citations

Two genes required for diabetes in BB rats. Evidence from cyclical intercrosses and backcrosses.

1984 • 78 citations

Prevention of diabetes mellitus in the BB/W rat with Cyclosporin-A.

1984 • 76 citations

Poly I:C Induces Development of Diabetes Mellitus in BB Rat

1992 • 73 citations

Insulin treatment prevents diabetes mellitus but not thyroiditis in RT6-depleted diabetes resistant BB/Wor rats

1991 • 67 citations

Diabetes segregates as a single locus in crosses between inbred BB rats prone or resistant to diabetes.

1991 • 63 citations

Altered Expression of Diabetes in BB/Wor Rats by Exposure to Viral Pathogens

1991 • 62 citations

Prevention of diabetes in BB/Wor rats by intrathymic islet injection.

1992 • 61 citations

Prevention of diabetes in the BB rat by essential fatty acid deficiency. Relationship between physiological and biochemical changes.

1990 • 61 citations

Chemicals trophic for the thymus: Risk for immunodeficiency and autoimmunity

1992 • 56 citations

Thyroid Antibodies in Spontaneous Autoimmune Thyroiditis in the Buffalo Rat

1976 • 51 citations

T cell dysfunction in the diabetes-prone BB rat. A role for thymic migrants that are not T cell precursors.

1988 • 51 citations

Studies on the thymus in nonobese diabetic mouse. I. Changes in the microenvironmental compartments.

1991 • 51 citations

Absence of RT6+ T cells in diabetes-prone biobreeding/Worcester rats is due to genetic and cell developmental defects.

1988 • 49 citations

Characterization of the Extracellular Matrix—Containing Giant Perivascular Spaces in the NOD Mouse Thymus

1993 • 46 citations

Thymus transplantation and disease prevention in the diabetes-prone Bio-Breeding rat.

1989 • 45 citations

Passive transfer of diabetes from BB/W to Wistar-Furth rats.

1985 • 42 citations

Thymic microenvironmental abnormalities and thymic selection in NZB.H-2bm12 mice.

1993 • 39 citations

Abnormal thymocyte maturation in spontaneously diabetic BB rats involves the deletion of CD4-8+ cells.

1990 • 39 citations

Epithelium‐Free Area in The Thymic Cortex of Rats

1992 • 34 citations

IDDM in Rats Induced by Thymectomy and Irradiation

1993 • 30 citations

Uveitis and Retinal Vasculitis in Acute Experimental Allergic Encephalomyelitis in the Lewis Rat: An Ultrastructural Study

1993 • 29 citations

Polygenic Nature of Spontaneous Diabetes in the Rat: Permissive MHC Haplotype and Presence of the Lymphopenic Trait of the BB Rat Are Not Sufficient to Produce Susceptibility

1992 • 27 citations

Multiple sclerosis and its animal models: the role of the major histocompatibility complex and the T cell receptor repertoire

1992 • 26 citations

Autoimmunity in Methylcholanthrene-Induced and Spontaneous Thyroiditis in Buffalo Strain Rats

1971 • 24 citations

Reduction of the RT6.2+ subset of T lymphocytes in brown Norway rats with mercury-induced renal autoimmunity

1991 • 23 citations

Spontaneous thyroiditis in laboratory rats

1969 • 22 citations

Biochemical Studies of RT6 Alloantigens in BB/Wor and Normal Rats: Evidence for Intact Unexpressed RT6a Structural Gene in Diabetes-Prone BB Rats

1990 • 22 citations

Defects in the thymic epithelial stroma of diabetes prone BB rats.

1989 • 22 citations

An RT6a Gene Is Transcribed and Translated in Lymphopenic Diabetes-Prone BB Rats

1993 • 21 citations

Effects of Irradiation on Diabetes in the BB/WOR Rat

1989 • 16 citations

GENETIC LINKAGE AND CELL DISTRIBUTION ANALYSIS OF T CELL ALLOANTIGENS IN THE RAT

1982 • 13 citations

Experimental autoallergic sialadenitis in the LEW rat

1991 • 10 citations

Experimental Allergic Encephalomyelitis in Aged F344 Rats

1976 • 9 citations

RATS HIGHLY SUSCEPTIBLE TO EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS OBTAINED BY CROSSING RATS FROM STRAINS WITH LOW SUSCEPTIBILITY

1982 • 9 citations