Prion peptide 106-126 as a model for prion replication and neurotoxicity

Seeding “one-dimensional crystallization” of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?

1993 • 2,146 citations

Human spongiform encephalopathy: The national institutes of health series of 300 cases of experimentally transmitted disease

1994 • 813 citations

Pure, postmitotic, polarized human neurons derived from NTera 2 cells provide a system for expressing exogenous proteins in terminally differentiated neurons

1992 • 612 citations

The human 37-kDa laminin receptor precursor interacts with the prion protein in eukaryotic cells

1997 • 435 citations

Characterization of Detergent-insoluble Complexes Containing the Cellular Prion Protein and Its Scrapie Isoform

1997 • 388 citations

Molecular biology and pathogenesis of prion diseases

1996 • 279 citations

Role of Microglia in Neuronal Cell Death in Prion Disease

1998 • 237 citations

Uptake, Degradation, and Release of Fibrillar and Soluble Forms of Alzheimer's Amyloid β-Peptide by Microglial Cells

1999 • 211 citations

Prion protein expression in different species: Analysis with a panel of new mAbs

1998 • 198 citations

Channel Formation by a Neurotoxic Prion Protein Fragment

1997 • 191 citations

Specific Inhibition of in Vitro Formation of Protease-resistant Prion Protein by Synthetic Peptides

1998 • 179 citations

Lysosomes as key organelles in the pathogenesis of prion encephalopathies

1992 • 179 citations

The Chaperone Protein BiP Binds to a Mutant Prion Protein and Mediates Its Degradation by the Proteasome

2000 • 170 citations

Proteinase‐resistant prion protein accumulation in Syrian hamster brain correlates with regional pathology and scrapie infectivity

1991 • 167 citations

Proteasomal Degradation and N-terminal Protease Resistance of the Codon 145 Mutant Prion Protein

1999 • 165 citations

Overexpression of Nonconvertible PrP ^c Δ114–121 in Scrapie-Infected Mouse Neuroblastoma Cells Leads to trans -Dominant Inhibition of Wild-Type PrP ^Sc Accumulation

1998 • 133 citations

Prion protein (PrP) synthetic peptides induce cellular PrP to acquire properties of the scrapie isoform.

1995 • 108 citations

Inherited Prion Diseases and Transmission to Rodents

1995 • 104 citations

Prion Peptide 106–126 Modulates the Aggregation of Cellular Prion Protein and Induces the Synthesis of Potentially Neurotoxic Transmembrane PrP

2002 • 104 citations

PrPSc-like prion protein peptide inhibits the function of cellular prion protein

2000 • 97 citations

Prion Protein Peptides: Optimal Toxicity and Peptide Blockade of Toxicity

2000 • 93 citations

Prion Protein Aggregation Reverted by Low Temperature in Transfected Cells Carrying a Prion Protein Gene Mutation

1997 • 91 citations

Transmissible spongiform encephalopathies, amyloidoses and yeast prions: Common threads?

2000 • 72 citations

The Role of Prion Peptide Structure and Aggregation in Toxicity and Membrane Binding

2000 • 70 citations

A Neurotoxic and Gliotrophic Fragment of the Prion Protein Increases Plasma Membrane Microviscosity

1997 • 60 citations

Cellular uptake of the prion protein fragment PrP106-126 in vitro.

1999 • 42 citations

Prion protein fragment interacts with PrP-deficient cells

1998 • 35 citations

Submicroscopic immunodetection of PrP in the brain of a patient with a new-variant of Creutzfeldt–Jakob disease

1999 • 32 citations