Disparate roles for TNF-alpha and Fas ligand in concanavalin A-induced hepatitis.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Apoptosis by Death Factor

1997 • 5,038 citations

A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells

1997 • 3,094 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege

1995 • 2,028 citations

Lethal effect of the anti-Fas antibody in mice

1993 • 1,915 citations

Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme

1995 • 1,625 citations

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-α

1997 • 1,608 citations

Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand

1994 • 1,549 citations

Protease activation during apoptosis: Death by a thousand cuts?

1995 • 1,335 citations

Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN- γ production

1997 • 1,172 citations

A T cell-dependent experimental liver injury in mice inducible by concanavalin A.

1992 • 1,041 citations

Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor alpha in vitro and in vivo.

1992 • 842 citations

Metalloproteinase-mediated release of human Fas ligand.

1995 • 835 citations

Involvement of an ICE-like protease in Fas-mediated apoptosis

1995 • 757 citations

Involvement of the CD95 (APO-1/Fas) receptor and ligand in liver damage.

1995 • 706 citations

Fas ligand in human serum

1996 • 682 citations

Expression of the Fas ligand in cells of T cell lineage.

1995 • 659 citations

A License to Kill

1996 • 649 citations

Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis

1995 • 616 citations

Differential expression of Fas (CD95) and Fas ligand on normal human phagocytes: implications for the regulation of apoptosis in neutrophils.

1996 • 574 citations

T cell activation-associated hepatic injury: mediation by tumor necrosis factors and protection by interleukin 6.

1994 • 519 citations

Essential roles of the Fas ligand in the development of hepatitis

1997 • 483 citations

Concanavalin A?induced T-cell?Mediated hepatic injury in mice: The role of tumor necrosis factor*1

1995 • 481 citations

Interferon gamma plays a critical role in T cell-dependent liver injury in mice initiated by concanavalin A

1996 • 421 citations

Suppression of concanavalin A-induced hepatitis in IFN-gamma(-/-) mice, but not in TNF-alpha(-/-) mice: role for IFN-gamma in activating apoptosis of hepatocytes.

1997 • 398 citations

Reversal of experimental autoimmune encephalomyelitis with a hydroxamate inhibitor of matrix metalloproteases.

1994 • 338 citations

Contenders in FasL/TNF death signaling

1995 • 319 citations

Systemic injection of a tripeptide inhibits the intracellular activation of CPP32-like proteases in vivo and fully protects mice against Fas-mediated fulminant liver destruction and death.

1996 • 281 citations

Inhibition of human skin fibroblast collagenase, thermolysin, and Pseudomonas aeruginosa elastase by peptide hydroxamic acids

1992 • 267 citations

TUMOR NECROSIS FACTOR IN SEPSIS: MEDIATOR OF MULTIPLE ORGAN FAILURE OR ESSENTIAL PART OF HOST DEFENSE?

1995 • 234 citations

Fas‐based lymphocyte‐mediated cytotoxicity against syngeneic activated lymphocytes: A regulatory pathway?

1994 • 157 citations

The 55-kD Tumor Necrosis Factor Receptor and CD95 Independently Signal Murine Hepatocyte Apoptosis and Subsequent Liver Failure

1996 • 130 citations

Role of sinusoidal endothelial cells of the liver in concanavalin A-induced hepatic injury in mice

1996 • 110 citations

Concanavalin A induces perforin-mediated but not Fas-mediated hepatic injury

1996 • 91 citations

Involvement of 26-kDa cell-associated TNF-alpha in experimental hepatitis and exacerbation of liver injury with a matrix metalloproteinase inhibitor.

1997 • 85 citations

A MATRIX METALLOPROTEINASE INHIBITOR PREVENTS PROCESSING OF TUMOR NECROSIS FACTOR α (TNFα) AND ABROGATES ENDOTOXIN-INDUCED LETHALITY

1997 • 83 citations

Apoptosis Mediated by the Fas System

1996 • 72 citations

PEG-BP-30 Monotherapy Attenuates the Cytokine-Mediated Inflammatory Cascade in Baboon Escherichia coli Septic Shock

1995 • 47 citations

The interleukin-1β converting enzyme family of cysteine proteases

1997 • 42 citations

Autoimmune disease results from multiple interactive defects in apoptosis induction molecules and signaling pathways.

1996 • 27 citations