Differential expression of Fas (CD95) and Fas ligand on normal human phagocytes: implications for the regulation of apoptosis in neutrophils.

The Fas Death Factor

1995 • 4,070 citations

Genistein, a specific inhibitor of tyrosine-specific protein kinases.

1987 • 3,773 citations

Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages.

1992 • 3,279 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family

1993 • 2,546 citations

Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis

1994 • 2,450 citations

Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

1995 • 1,662 citations

Fas and Perforin Pathways as Major Mechanisms of T Cell-Mediated Cytotoxicity

1994 • 1,558 citations

Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation

1995 • 1,549 citations

Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas

1995 • 1,346 citations

Massive Cell Death of Immature Hematopoietic Cells and Neurons in Bcl-x-Deficient Mice

1995 • 1,167 citations

Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation.

1991 • 1,132 citations

Modulation of granulocyte survival and programmed cell death by cytokines and bacterial products

1992 • 1,103 citations

Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways

1994 • 1,073 citations

Fas ligand mediates activation-induced cell death in human T lymphocytes.

1995 • 949 citations

Neutrophils in Human Diseases

1987 • 852 citations

Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity.

1993 • 801 citations

Fas ligand in human serum

1996 • 682 citations

Expression of the functional soluble form of human fas ligand in activated lymphocytes.

1995 • 656 citations

Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase.

1994 • 582 citations

Programmed Cell Death in the Immune System

1991 • 575 citations

Purification and characterization of the Fas-ligand that induces apoptosis.

1994 • 521 citations

Glucocorticoid treatment inhibits apoptosis in human neutrophils. Separation of survival and activation outcomes.

1995 • 508 citations

CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+T cells

1995 • 470 citations

Effect of bcl-2 on Fas antigen-mediated cell death.

1993 • 442 citations

Human neutrophils lose their surface Fc gamma RIII and acquire Annexin V binding sites during apoptosis in vitro

1995 • 435 citations

Bcl-XL and Bcl-2 repress a common pathway of cell death.

1995 • 406 citations

Fas antigen is the major target molecule for CD4+ T cell-mediated cytotoxicity.

1994 • 386 citations

Prolongation of survival of human polymorphonuclear neutrophils by granulocyte-macrophage colony-stimulating factor is caused by inhibition of programmed cell death

1992 • 367 citations

Fas and Fas Ligand: A Death Factor and Its Receptor

1994 • 354 citations

Role for ceramide as an endogenous mediator of Fas-induced cytotoxicity.

1995 • 323 citations

Differential expression of bcl-2 and susceptibility to anti-Fas- mediated cell death in peripheral blood lymphocytes, monocytes, and neutrophils

1994 • 320 citations

Immunosuppression by activated human neutrophils. Dependence on the myeloperoxidase system.

1987 • 304 citations

Apoptosis in human eosinophils. Programmed cell death in the eosinophil leads to phagocytosis by macrophages and is modulated by IL-5.

1992 • 296 citations

Glucocorticoids inhibit apoptosis of human neutrophils

1995 • 294 citations

Differential regulation of human monocyte programmed cell death (apoptosis) by chemotactic factors and pro-inflammatory cytokines.

1991 • 294 citations

bcl-2 inhibits apoptosis of neutrophils but not their engulfment by macrophages.

1994 • 288 citations

Induction of apoptosis in human eosinophils by anti-Fas antibody treatment in vitro

1995 • 197 citations

TCR/CD3 coupling to Fas-based cytotoxicity.

1995 • 196 citations

Fas ligation triggers apoptosis in macrophages but not endothelial cells

1994 • 192 citations

Tyrosine kinase activation provides an early and requisite signal for Fas-induced apoptosis.

1994 • 184 citations

Decreased membrane phospholipid packing and decreased cell size precede DNA cleavage in mature mouse B cell apoptosis.

1994 • 161 citations

Regulation of cell adhesion molecule expression and function associated with neutrophil apoptosis

1995 • 158 citations

Fas‐based lymphocyte‐mediated cytotoxicity against syngeneic activated lymphocytes: A regulatory pathway?

1994 • 157 citations

Transforming growth factor beta abrogates the effects of hematopoietins on eosinophils and induces their apoptosis.

1994 • 151 citations

Transient elevations of cytosolic free calcium retard subsequent apoptosis in neutrophils in vitro.

1993 • 141 citations

Regulation of apoptosis in neutrophils--Fas track to death?

1995 • 127 citations

Fas ligand-mediated cytotoxicity is directly responsible for apoptosis of normal CD4+ T cells responding to a bacterial superantigen.

1995 • 119 citations

Interleukin‐2 prevention of apoptosis in human neutrophils

1994 • 117 citations

Primitive human hematopoietic precursors express Bcl-x but not Bcl-2

1995 • 104 citations

Dysregulated bcl-2 expression inhibits apoptosis but not differentiation of retinoic acid-induced HL-60 granulocytes

1994 • 99 citations

Separate metabolic pathways leading to DNA fragmentation and apoptotic chromatin condensation.

1994 • 98 citations

The target cell nucleus is not required for cell-mediated granzyme- or Fas-based cytotoxicity.

1995 • 92 citations

Fas antigen-mediated DNA fragmentation and apoptotic morphologic changes are regulated by elevated cytosolic Ca2+ level.

1995 • 90 citations

A specific intercellular pathway of apoptotic cell death is defective in the mature peripheral T cells of autoimmune lpr and gld mice

1994 • 81 citations

Cross-linking of CD45 enhances activation of the respiratory burst in response to specific stimuli in human phagocytes.

1995 • 49 citations

Induction of in vitro differentiation of mouse embryonal carcinoma (F9) and erythroleukemia (MEL) cells by herbimycin A, an inhibitor of protein phosphorylation.

1989 • 41 citations

Fas antigen-mediated DNA fragmentation and apoptotic morphologic changes are regulated by elevated cytosolic Ca[2+] level

1995 • 3 citations