IL-4 Exacerbates Anaphylaxis

Interleukin-13: Central Mediator of Allergic Asthma

1998 • 2,642 citations

Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells

1996 • 1,618 citations

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene

1996 • 1,304 citations

IL-4 directs the development of Th2-like helper effectors.

1990 • 1,261 citations

Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies.

1987 • 1,060 citations

Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells.

1990 • 954 citations

Two types of mouse helper T-cell clone

1987 • 813 citations

B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells.

1986 • 797 citations

Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1

1985 • 749 citations

Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity.

1996 • 734 citations

IFN-gamma regulates the isotypes of Ig secreted during in vivo humoral immune responses.

1988 • 731 citations

IL-4 is required to generate and sustain in vivo IgE responses.

1988 • 671 citations

CYTOKINE REGULATION OF HOST DEFENSE AGAINST PARASITIC GASTROINTESTINAL NEMATODES:Lessons from Studies with Rodent Models^*

1997 • 648 citations

Biological Activity of Recombinant Human Interleukin-2 Produced in Escherichia coli

1984 • 600 citations

IL-13, IL-4Rα, and Stat6 Are Required for the Expulsion of the Gastrointestinal Nematode Parasite Nippostrongylus brasiliensis

1998 • 582 citations

Regulation of interferon-γ production by IL-12 and IL-18

1998 • 526 citations

B220: a B cell-specific member of the T200 glycoprotein family

1981 • 525 citations

IL-4 Induces Mucin Gene Expression and Goblet Cell Metaplasia In Vitro and In Vivo

1999 • 453 citations

Increased expression of Ia antigens on resting B cells: an additional role for B-cell growth factor.

1984 • 438 citations

Interleukin-4 Receptor in Moderate Atopic Asthma

1999 • 421 citations

IL-4 induces allergic-like inflammatory disease and alters T cell development in transgenic mice

1990 • 410 citations

Tumor necrosis factor combines with IL-4 or IFN-gamma to selectively enhance endothelial cell adhesiveness for T cells. The contribution of vascular cell adhesion molecule-1-dependent and -independent binding mechanisms.

1991 • 398 citations

Interleukin 4 is important in protective immunity to a gastrointestinal nematode infection in mice.

1991 • 376 citations

IL-4/IL-13 signaling beyond JAK/STAT

2000 • 369 citations

Interleukin (IL) 4 and IL-13 act on human lung fibroblasts. Implication in asthma.

1998 • 353 citations

Anti-cytokine antibodies as carrier proteins. Prolongation of in vivo effects of exogenous cytokines by injection of cytokine-anti-cytokine antibody complexes.

1993 • 352 citations

An interleukin 4 (IL-4)-independent pathway for CD4⁺T cell IL-4 production is revealed in IL-4 receptor-deficient mice

1997 • 334 citations

Pathways of anaphylaxis in the mouse

2002 • 303 citations

Antigen presentation by supported planar membranes containing affinity-purified I-Ad.

1984 • 281 citations

Antibodies to IL-3 and IL-4 suppress helminth-induced intestinal mastocytosis.

1991 • 266 citations

IL-4 enhances proliferation and mediator release in mature human mast cells

1999 • 248 citations

Th2-induced airway mucus production is dependent on IL-4Ralpha, but not on eosinophils.

1999 • 244 citations

The Th2 Lymphocyte Products IL-4 and IL-13 Rapidly Induce Airway Hyperresponsiveness Through Direct Effects on Resident Airway Cells

2002 • 219 citations

IL-13 alters mucociliary differentiation and ciliary beating of human respiratory epithelial cells

2001 • 218 citations

IL-13 alters mucociliary differentiation and ciliary beating of human respiratory epithelial cells

2001 • 209 citations

Stat6 Signaling Promotes Protective Immunity Against Trichinella spiralis Through a Mast Cell- and T Cell-Dependent Mechanism

2000 • 196 citations

Absence of Fc epsilonRI alpha chain results in upregulation of Fc gammaRIII-dependent mast cell degranulation and anaphylaxis. Evidence of competition between Fc epsilonRI and Fc gammaRIII for limiting amounts of FcR beta and gamma chains.

1997 • 195 citations

Th2-Induced Airway Mucus Production Is Dependent on IL-4Rα, But Not on Eosinophils

1999 • 192 citations

Dissecting NK cell development using a novel alymphoid mouse model: investigating the role of the c-abl proto-oncogene in murine NK cell differentiation.

1999 • 186 citations

IL-4 treatment can cure established gastrointestinal nematode infections in immunocompetent and immunodeficient mice.

1995 • 166 citations

Dissecting NK Cell Development Using a Novel Alymphoid Mouse Model: Investigating the Role of the c-abl Proto-Oncogene in Murine NK Cell Differentiation

1999 • 163 citations

IL-13 protects mice from lipopolysaccharide-induced lethal endotoxemia: correlation with down-modulation of TNF-alpha, IFN-gamma, and IL-12 production.

1997 • 161 citations

IL-13 and IL-4 Up-Regulate Cysteinyl Leukotriene 1 Receptor Expression in Human Monocytes and Macrophages

2001 • 160 citations

IL-13-dependent autocrine signaling mediates altered responsiveness of IgE-sensitized airway smooth muscle

2002 • 148 citations

Interferon-gamma suppresses B cell stimulation factor (BSF-1) induction of class II MHC determinants on B cells.

1986 • 138 citations

The role of IL-13 in helminth-induced inflammation and protective immunity against nematode infections

1999 • 131 citations

Inhibition of IgE binding to mast cells and basophils by monoclonal antibodies to murine IgE

1984 • 128 citations

Cutting Edge: IL-4 Receptor Expression by Non-Bone Marrow-Derived Cells Is Required to Expel Gastrointestinal Nematode Parasites

2001 • 102 citations

IFN inhibits inflammatory responses and protective immunity in mice infected with the nematode parasite, Nippostrongylus brasiliensis.

1993 • 95 citations

Infection with Nippostrongylus brasiliensis or injection of anti-IgD antibodies markedly enhances Fc-receptor-mediated interleukin 4 production by non-B, non-T cells.

1990 • 91 citations

Stable and functional lymphoid reconstitution of common cytokine receptor γ chain deficient mice by retroviral-mediated gene transfer

2000 • 89 citations

Phase I evaluation of thrice-daily intravenous bolus interleukin-4 in patients with refractory malignancy.

1992 • 89 citations

IL-13 Overexpression Predisposes to Anaphylaxis Following Antigen Sensitization

2001 • 85 citations

Regulation of murine in vivo lgG and lgE responses by a monoclonal anti-IL-4 receptor antibody

1991 • 79 citations

In vitro and in vivo studies with purified recombinant human interleukin 5

1990 • 42 citations

Local intestinal immune responses to infections with Trichinella spiralis. Real-time, continuous assay of cytokines in the intestinal (afferent) and efferent thoracic duct lymph of rats.

1996 • 40 citations

Paf induces rat plasma extravasation and releases eicosanoids during anaphylaxis

1991 • 28 citations

Regulation of paf-acether receptor expression in human B cells.

1992 • 27 citations

Cellular and Molecular Analysis of Lymphoid Development Using RAG-Deficient Mice

1996 • 18 citations