Mutational analysis of the discs large tumour suppressor identifies domains responsible for human papillomavirus type 18 E6-mediated degradation

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

Papillomavirus infections — a major cause of human cancers

1996 • 1,536 citations

Structure and transcription of human papillomavirus sequences in cervical carcinoma cells

1985 • 1,481 citations

Recognition of Unique Carboxyl-Terminal Motifs by Distinct PDZ Domains

1997 • 1,371 citations

Cooperative Regulation of Cell Polarity and Growth by Drosophila Tumor Suppressors

2000 • 908 citations

The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions

1991 • 902 citations

A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18.

1991 • 872 citations

Transcription of human papillomavirus type 16 early genes in a cervical cancer and a cancer-derived cell line and identification of the E7 protein.

1986 • 665 citations

PDZ domains: fundamental building blocks in the organization of protein complexes at the plasma membrane

1999 • 469 citations

Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor protein

1997 • 462 citations

Human Scribble (Vartul) Is Targeted for Ubiquitin-Mediated Degradation by the High-Risk Papillomavirus E6 Proteins and the E6AP Ubiquitin-Protein Ligase

2000 • 444 citations

Binding of APC to the Human Homolog of the Drosophila Discs Large Tumor Suppressor Protein

1996 • 430 citations

Dlg protein is required for junction structure, cell polarity, and proliferation control in Drosophila epithelia.

1996 • 422 citations

The E6 protein of human papillomavirus type 16 binds to and inhibits co-activation by CBP and p300

1999 • 417 citations

Molecular characterization and spatial distribution of SAP97, a novel presynaptic protein homologous to SAP90 and the Drosophila discs-large tumor suppressor protein

1995 • 388 citations

Localization of the E6-AP regions that direct human papillomavirus E6 binding, association with p53, and ubiquitination of associated proteins.

1993 • 377 citations

Binding of human virus oncoproteins to hDlg/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor protein

1997 • 376 citations

Cloning and characterization of hdlg: the human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1.

1994 • 365 citations

Human papillomavirus type 16 DNA cooperates with activated ras in transforming primary cells.

1987 • 351 citations

Interactions of the PDZ-protein MAGI-1 with adenovirus E4-ORF1 and high-risk papillomavirus E6 oncoproteins

2000 • 296 citations

Oncogenic human papillomavirus E6 proteins target the discs large tumour suppressor for proteasome-mediated degradation

1999 • 295 citations

Inhibition of Bak-induced apoptosis by HPV-18 E6

1998 • 282 citations

Interaction of Papillomavirus E6 Oncoproteins with a Putative Calcium-Binding Protein

1995 • 272 citations

Multi-PDZ Domain Protein MUPP1 Is a Cellular Target for both Adenovirus E4-ORF1 and High-Risk Papillomavirus Type 18 E6 Oncoproteins

2000 • 259 citations

Cell signalling: MAGUK magic

1996 • 248 citations

Identification of the HPV-16 E6 protein from transformed mouse cells and human cervical carcinoma cell lines.

1987 • 230 citations

Characterization of PDZ-binding kinase, a mitotic kinase

2000 • 202 citations

Multiple Functions of Human Papillomavirus Type 16 E6 Contribute to the Immortalization of Mammary Epithelial Cells

1999 • 198 citations

The ability of human papillomavirus E6 proteins to target p53 for degradation in vivo correlates with their ability to abrogate actinomycin D-induced growth arrest

1994 • 185 citations

The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase

2000 • 184 citations

E3-Ubiquitin Ligase/E6-AP Links Multicopy Maintenance Protein 7 to the Ubiquitination Pathway by a Novel Motif, the L2G Box

1998 • 180 citations

Identification of Human Papillomavirus Type 18 E6 Polypeptide in Cells Derived from Human Cervical Carcinomas

1987 • 141 citations

Subcellular targeting and cytoskeletal attachment of SAP97 to the epithelial lateral membrane

1998 • 137 citations

Inhibition of patterned cell shape change and cell invasion by Discs large during Drosophila oogenesis

1997 • 129 citations

Tax oncoprotein of HTLV-1 binds to the human homologue of Drosophila discs large tumor suppressor protein, hDLG, and perturbs its function in cell growth control

1999 • 122 citations

Polarized signaling: basolateral receptor localization in epithelial cells by PDZ-containing proteins

1997 • 119 citations

E-cadherin mediated cell adhesion recruits SAP97 into the cortical cytoskeleton

1998 • 114 citations

HPV E6 targeted degradation of the discs large protein: evidence for the involvement of a novel ubiquitin ligase

2000 • 104 citations

Mutational analysis of HPV-18 E6 identifies domains required for p53 degradation in vitro, abolition of p53 transactivation in vivo and immortalisation of primary BMK cells.

1994 • 92 citations

HPV-18 E6 mediated inhibition of p53 DNA binding activity is independent of E6 induced degradation.

1995 • 70 citations

Differential regulation of human papillomavirus E6 by protein kinase A: conditional degradation of human discs large protein by oncogenic E6

2000 • 64 citations

Interactions Between Papillomavirus Proteins and Tumor Suppressor Gene Products

1994 • 61 citations

Comparison of human papillomavirus type 18 (HPV-18) E6-mediated degradation of p53 in vitro and in vivo reveals significant differences based on p53 structure and cell type but little difference with respect to mutants of HPV-18 E6.

1998 • 22 citations

Degradation of p53 only is not sufficient for the growth stimulatory effect of human papillomavirus 16 E6 oncoprotein in human embryonic fibroblasts

1994 • 19 citations

Dispensability of p53 degradation for tumorigenicity and decreased serum requirement of human papillomavirus type 16 E6

1998 • 16 citations