Regulatory T cells and the PD-L1/PD-1 pathway mediate immune suppression in malignant human brain tumors

The 2007 WHO Classification of Tumours of the Central Nervous System

2007 • 13,561 citations

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

2004 • 4,872 citations

Immunotherapy of Diffuse Gliomas: Biological Background, Current Status and Future Developments

2009 • 3,897 citations

Guía de práctica clínica para el tratamiento de los tumores intracraneales

2009 • 3,409 citations

N<scp>aturally</scp>A<scp>rising</scp>CD4⁺R<scp>egulatory</scp>T C<scp>ells for</scp>I<scp>mmunologic</scp>S<scp>elf</scp>-T<scp>olerance and</scp>N<scp>egative</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponses</scp>

2003 • 3,323 citations

CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells

2006 • 2,516 citations

Regulatory T Cells

2000 • 1,827 citations

Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma

2006 • 1,254 citations

Foxp3-dependent programme of regulatory T-cell differentiation

2007 • 1,106 citations

Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody.

1999 • 1,066 citations

Three or more routes for leukocyte migration into the central nervous system

2003 • 1,005 citations

Transient expression of FOXP3 in human activated nonregulatory CD4⁺ T cells

2006 • 973 citations

TGF-β1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells

2005 • 955 citations

Unique Chemotactic Response Profile and Specific Expression of Chemokine Receptors Ccr4 and Ccr8 by Cd4+Cd25+ Regulatory T Cells

2001 • 888 citations

Toll-like receptor 2 controls expansion and function of regulatory T cells

2006 • 756 citations

What is immune privilege (not)?

2006 • 708 citations

Natural regulatory T cells: mechanisms of suppression

2007 • 704 citations

Antigen-dependent Proliferation of CD4+ CD25+ Regulatory T Cells In Vivo

2003 • 600 citations

Interaction of PD-L1 on tumor cells with PD-1 on tumor-specific T cells as a mechanism of immune evasion: implications for tumor immunotherapy

2004 • 571 citations

Increased Regulatory T-Cell Fraction Amidst a Diminished CD4 Compartment Explains Cellular Immune Defects in Patients with Malignant Glioma

2006 • 570 citations

Ki67 protein: the immaculate deception?

2002 • 495 citations

Brain and Other Central Nervous System Cancers: Recent Trends in Incidence and Mortality

1999 • 429 citations

TGF-β regulatesin vivoexpansion of Foxp3-expressing CD4⁺CD25⁺regulatory T cells responsible for protection against diabetes

2004 • 425 citations

Transient regulatory T-cells: A state attained by all activated human T-cells

2006 • 336 citations

The role of CD28 and cytotoxic T‐lymphocyte antigen‐4 (CTLA‐4) in regulatory T‐cell biology

2006 • 289 citations

An increase in CD4+CD25+FOXP3+ regulatory T cells in tumor-infiltrating lymphocytes of human glioblastoma multiforme1

2006 • 286 citations

Preferential migration of regulatory T cells mediated by glioma-secreted chemokines can be blocked with chemotherapy

2007 • 225 citations

Dynamic cross-talk between tumor and immune cells in orchestrating the immunosuppressive network at the tumor microenvironment

2007 • 213 citations

CD4+FoxP3+ regulatory T cells gradually accumulate in gliomas during tumor growth and efficiently suppress antiglioma immune responses in vivo

2007 • 210 citations

Toll-like receptors on regulatory T cells: expanding immune regulation

2006 • 201 citations

An antigen-specific pathway for CD8 T cells across the blood-brain barrier

2007 • 198 citations

Tumours of the central nervous system

2021 • 167 citations

Downregulation of major histocompatibility complex antigens in invading glioma cells: stealth invasion of the brain

2005 • 165 citations

Administration of a CD25-Directed Immunotoxin, LMB-2, to Patients with Metastatic Melanoma Induces a Selective Partial Reduction in Regulatory T Cells In Vivo

2007 • 163 citations

Vascular microenvironment in gliomas.

2000 • 163 citations

Focus on TILs: Prognostic significance of tumor infiltrating lymphocytes in human glioma.

2007 • 161 citations

Prolongation of survival following depletion of CD4+CD25+ regulatory T cells in mice with experimental brain tumors

2006 • 149 citations

Vaccination against the Forkhead Family Transcription Factor Foxp3 Enhances Tumor Immunity

2007 • 146 citations

Human Glioma-Induced Immunosuppression Involves Soluble Factor(s) That Alters Monocyte Cytokine Profile and Surface Markers

1999 • 140 citations

Autologous glioma cell vaccine admixed with interleukin-4 gene transfected fibroblasts in the treatment of patients with malignant gliomas

2007 • 129 citations

Cell-surface IL-7 receptor expression facilitates the purification of FOXP3+ regulatory T cells

2006 • 127 citations

CD4 regulatory T cells in human cancer pathogenesis

2006 • 117 citations

Elimination of regulatory T cells is essential for an effective vaccination with tumor lysate‐pulsed dendritic cells in a murine glioma model

2007 • 91 citations

CD4+CXCR4highCD69+ T Cells Accumulate in Lung Adenocarcinoma

2006 • 83 citations

DENDRITIC CELL VACCINATION IN PATIENTS WITH MALIGNANT GLIOMAS

2006 • 66 citations

Vascular Microenvironment in Gliomas

2004 • 61 citations

Management of metastatic brain tumors

1994 • 55 citations

Regulatory T cells and innate immune regulation in tumor immunity

2006 • 51 citations

Ultrasonic aspiration in neurosurgery

1984 • 45 citations

Preferential migration of regulatory T cells mediated by gliomasecreted chemokines can be blocked with chemotherapy

2007 • 24 citations

Protein Expression of Fas, Fas Ligand, Bcl-2 and TGF 2 and Correlation with Survival in Initial and Recurrent Human Gliomas

2004 • 22 citations

Keratinocyte Growth Factor Induces Expansion of Murine Peripheral CD4+Foxp3+ Regulatory T Cells and Increases Their Thymic Output

2007 • 21 citations

Brain tumor immunotherapy: an immunologist’s perspective

2003 • 19 citations

Integration of a Variable Action Suction Adapter into Ultrasonic Aspirators

1999 • 7 citations

Improved histopathological evaluation of gliomas using tissue fragments obtained by ultrasonic aspiration.

2004 • 5 citations