Elimination of regulatory T cells is essential for an effective vaccination with tumor lysate‐pulsed dendritic cells in a murine glioma model

Cancer immunotherapy: moving beyond current vaccines

2004 • 2,932 citations

The Central Role of CD4+ T Cells in the Antitumor Immune Response

1998 • 1,332 citations

Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody.

1999 • 1,066 citations

Synergism of Cytotoxic T Lymphocyte–Associated Antigen 4 Blockade and Depletion of Cd25+ Regulatory T Cells in Antitumor Therapy Reveals Alternative Pathways for Suppression of Autoreactive Cytotoxic T Lymphocyte Responses

2001 • 1,033 citations

Direct Expansion of Functional CD25+ CD4+ Regulatory T Cells by Antigen-processing Dendritic Cells

2003 • 893 citations

CD4⁺CD25⁺ regulatory T cells suppress tumor immunity but are sensitive to cyclophosphamide which allows immunotherapy of established tumors to be curative

2004 • 854 citations

Increased Regulatory T-Cell Fraction Amidst a Diminished CD4 Compartment Explains Cellular Immune Defects in Patients with Malignant Glioma

2006 • 570 citations

Dendritic Cell Vaccination in Glioblastoma Patients Induces Systemic and Intracranial T-cell Responses Modulated by the Local Central Nervous System Tumor Microenvironment

2005 • 534 citations

Vaccination with Tumor Lysate-Pulsed Dendritic Cells Elicits Antigen-Specific, Cytotoxic T-Cells in Patients with Malignant Glioma

2004 • 528 citations

Vaccination of malignant glioma patients with peptide-pulsed dendritic cells elicits systemic cytotoxicity and intracranial T-cell infiltration.

2001 • 501 citations

Murine dendritic cells pulsed with whole tumor lysates mediate potent antitumor immune responsesin vitroandin vivo

1998 • 457 citations

Identification of Tyrosinase-related Protein 2 as a Tumor Rejection Antigen for the B16 Melanoma

1997 • 405 citations

Fas ligand expression by astrocytoma in vivo: maintaining immune privilege in the brain?

1997 • 403 citations

Tumor-Specific CD4+ T Cells Have a Major “Post-Licensing” Role in CTL Mediated Anti-Tumor Immunity

2000 • 337 citations

A Functional Role of HLA-G Expression in Human Gliomas: An Alternative Strategy of Immune Escape

2002 • 336 citations

Clinical Evaluation of Dendritic Cell Vaccination for Patients with Recurrent Glioma: Results of a Clinical Phase I/II Trial

2005 • 308 citations

Expansion of FOXP3high regulatory T cells by human dendritic cells (DCs) in vitro and after injection of cytokine-matured DCs in myeloma patients

2006 • 302 citations

An increase in CD4+CD25+FOXP3+ regulatory T cells in tumor-infiltrating lymphocytes of human glioblastoma multiforme1

2006 • 286 citations

Identification of TRP-2 as a Human Tumor Antigen Recognized by Cytotoxic T Lymphocytes

1996 • 272 citations

Vaccination of recurrent glioma patients with tumour lysate-pulsed dendritic cells elicits immune responses: results of a clinical phase I/II trial

2003 • 257 citations

Treatment of intracranial gliomas with bone marrow—derived dendritic cells pulsed with tumor antigens

1999 • 239 citations

CD4+ CD25+ Regulatory T Cells Control T Helper Cell Type 1 Responses to Foreign Antigens Induced by Mature Dendritic Cells In Vivo

2003 • 230 citations

CD4+FoxP3+ regulatory T cells gradually accumulate in gliomas during tumor growth and efficiently suppress antiglioma immune responses in vivo

2007 • 210 citations

Induction of Antitumor Immunity with Dendritic Cells Transduced with Adenovirus Vector-Encoding Endogenous Tumor-Associated Antigens

1999 • 206 citations

Identification of a shared HLA-A*0201-restricted T-cell epitope from the melanoma antigen tyrosinase-related protein 2 (TRP2).

1998 • 199 citations

Dendritic Cells Charged with Apoptotic Tumor Cells Induce Long-Lived Protective CD4+ and CD8+ T Cell Immunity against B16 Melanoma

2003 • 192 citations

HER-2, gp100, and MAGE-1 Are Expressed in Human Glioblastoma and Recognized by Cytotoxic T Cells

2004 • 192 citations

Surgery and adjuvant dendritic cell-based tumour vaccination for patients with relapsed malignant glioma, a feasibility study

2004 • 171 citations

Systemic Anti-CD25 Monoclonal Antibody Administration Safely Enhances Immunity in Murine Glioma without Eliminating Regulatory T Cells

2006 • 169 citations

Dendritic Cells Loaded with Stressed Tumor Cells Elicit Long-Lasting Protective Tumor Immunity in Mice Depleted of CD4+CD25+ Regulatory T Cells

2005 • 161 citations

CTL Effector Function Within the Central Nervous System Requires CD4+ T Cells

1998 • 161 citations

Human Glioma-derived Interleukin-10 Inhibits Antitumor Immune Responses In Vitro

1995 • 160 citations

Molecular detection of tumor-associated antigens shared by human cutaneous melanomas and gliomas.

1997 • 154 citations

T cell-mediated, IFN-gamma-facilitated rejection of murine B16 melanomas.

1998 • 152 citations

Prolongation of survival following depletion of CD4+CD25+ regulatory T cells in mice with experimental brain tumors

2006 • 149 citations

Vaccination against the Forkhead Family Transcription Factor Foxp3 Enhances Tumor Immunity

2007 • 146 citations

CD4+CD25+FoxP3+ T-cell infiltration and heme oxygenase-1 expression correlate with tumor grade in human gliomas

2007 • 133 citations

Bone marrow-derived dendritic cells pulsed with tumor homogenate induce immunity against syngeneic intracerebral glioma

2000 • 128 citations

Dendritic cells break tolerance and induce protective immunity against a melanocyte differentiation antigen in an autologous melanoma model.

2000 • 127 citations

Immunotherapeutic targeting of shared melanoma-associated antigens in a murine glioma model.

2003 • 118 citations

T Cell-Mediated, IFN-γ-Facilitated Rejection of Murine B16 Melanomas

1998 • 117 citations

Genetic vaccination with 'self' tyrosinase-related protein 2 causes melanoma eradication but not vitiligo

2000 • 116 citations

Expression of cancer testis genes in human brain tumors.

2000 • 116 citations

Antitumor Effect of Immunizations With Fusions of Dendritic and Glioma Cells in a Mouse Brain Tumor Model

2001 • 107 citations

Current Methods for Loading Dendritic Cells With Tumor Antigen for the Induction of Antitumor Immunity

2002 • 97 citations

Expression of MAGE and GAGE in high-grade brain tumors: a potential target for specific immunotherapy and diagnostic markers.

1999 • 90 citations

Immunization with dendritic cells pulsed with tumor extract increases survival of mice bearing intracranial gliomas.

2001 • 87 citations

An improved flow cytometric assay for the determination of cytotoxic T lymphocyte activity

2002 • 78 citations

Molecular and Functional Analysis of Tyrosinase-Related Protein (TRP)-2 as a Cytotoxic T Lymphocyte Target in Patients With Malignant Glioma

2003 • 72 citations

A dendritic cell vaccine induces protective immunity to intracranial growth of glioma.

2002 • 69 citations

In vitro Prostaglandin E2 production by glioblastoma cells and its effect on interleukin-2 activation of oncolytic lymphocytes

1990 • 68 citations

Dendritic cells pulsed with tumor extract-cationic liposome complex increase the induction of cytotoxic T lymphocytes in mouse brain tumor

2001 • 48 citations

Human glioblastoma cell derived transforming growth factor-β2: evidence for secretion of both high and low molecular weight biologically active forms

1991 • 43 citations

Dendritic cells are essential for priming but inefficient for boosting antitumour immune response in an orthotopic murine glioma model

2005 • 40 citations

Dendritic cells pulsed with glioma lysates induce immunity against syngeneic intracranial gliomas and increase survival of tumor-bearing mice

2006 • 37 citations

A DNA vaccine expressing tyrosinase-related protein-2 induces T-cell-mediated protection against mouse glioblastoma

2003 • 34 citations

In Vivo Depletion of CD4+CD25+ Regulatory T Cells Enhances the Antigen-Specific Primary and Memory CTL Response Elicited by Mature mRNA-Electroporated Dendritic Cells

2005 • 32 citations

Intratumoral injection of dendritic and irradiated glioma cells induces anti-tumor effects in a mouse brain tumor model

2002 • 30 citations

Loading DCs with Ag

2004 • 13 citations