Regulatory T cells and innate immune regulation in tumor immunity

PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer

2016 • 29,943 citations

Inflammation and cancer

2002 • 14,174 citations

Pathogen Recognition and Innate Immunity

2006 • 11,197 citations

Toll-like receptor signalling

2004 • 7,983 citations

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

2004 • 4,872 citations

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

2003 • 4,529 citations

Toll-like receptor control of the adaptive immune responses

2004 • 4,092 citations

The Role of Tumoral FOXP3 on Cell Proliferation, Migration, and Invasion in Gastric Cancer

2017 • 4,003 citations

Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8

2004 • 3,766 citations

Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA

2004 • 3,325 citations

N<scp>aturally</scp>A<scp>rising</scp>CD4⁺R<scp>egulatory</scp>T C<scp>ells for</scp>I<scp>mmunologic</scp>S<scp>elf</scp>-T<scp>olerance and</scp>N<scp>egative</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponses</scp>

2003 • 3,323 citations

Tumour-educated macrophages promote tumour progression and metastasis

2004 • 3,259 citations

Toll-like receptors in innate immunity

2004 • 3,233 citations

Intratumoral T Cells, Recurrence, and Survival in Epithelial Ovarian Cancer

2003 • 3,194 citations

Tolerogenic Dendritic Cells

2003 • 3,131 citations

Cancer immunotherapy: moving beyond current vaccines

2004 • 2,932 citations

NF-κB: linking inflammation and immunity to cancer development and progression

2005 • 2,878 citations

An essential role for Scurfin in CD4+CD25+ T regulatory cells

2003 • 2,825 citations

The Immunobiology of Cancer Immunosurveillance and Immunoediting

2004 • 2,788 citations

Cancer Regression and Autoimmunity in Patients After Clonal Repopulation with Antitumor Lymphocytes

2002 • 2,781 citations

Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis

2006 • 2,597 citations

Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway

2002 • 2,438 citations

NF-κB functions as a tumour promoter in inflammation-associated cancer

2004 • 2,370 citations

IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer

2004 • 2,361 citations

Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3

2005 • 2,256 citations

Intraepithelial CD8⁺tumor-infiltrating lymphocytes and a high CD8⁺/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer

2005 • 2,226 citations

CD4+CD25+ suppressor T cells: more questions than answers

2002 • 2,202 citations

IRF-7 is the master regulator of type-I interferon-dependent immune responses

2005 • 2,108 citations

Toll Pathway-Dependent Blockade of CD4 ⁺ CD25 ⁺ T Cell-Mediated Suppression by Dendritic Cells

2003 • 2,023 citations

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

1994 • 1,995 citations

Recognition of single-stranded RNA viruses by Toll-like receptor 7

2004 • 1,777 citations

CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity

2002 • 1,733 citations

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

2001 • 1,659 citations

Induction of Interleukin 10–Producing, Nonproliferating Cd4+ T Cells with Regulatory Properties by Repetitive Stimulation with Allogeneic Immature Human Dendritic Cells

2000 • 1,577 citations

Immunologic tolerance maintained by CD25⁺ CD4⁺ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance

2001 • 1,515 citations

Induction of Tumor Immunity by Removing CD25+CD4+ T Cells: A Common Basis Between Tumor Immunity and Autoimmunity

1999 • 1,475 citations

Prevalence of Regulatory T Cells Is Increased in Peripheral Blood and Tumor Microenvironment of Patients with Pancreas or Breast Adenocarcinoma

2002 • 1,454 citations

Regulatory T cells in transplantation tolerance

2003 • 1,323 citations

Regulatory T Cells in Autoimmmunity

2000 • 1,267 citations

Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25– T cells

2003 • 1,252 citations

Inducing and expanding regulatory T cell populations by foreign antigen

2005 • 1,245 citations

Regulatory CD4(+)CD25(+) T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer.

2001 • 1,126 citations

IKKβ Couples Hepatocyte Death to Cytokine-Driven Compensatory Proliferation that Promotes Chemical Hepatocarcinogenesis

2005 • 1,125 citations

Synergism of Cytotoxic T Lymphocyte–Associated Antigen 4 Blockade and Depletion of Cd25+ Regulatory T Cells in Antitumor Therapy Reveals Alternative Pathways for Suppression of Autoreactive Cytotoxic T Lymphocyte Responses

2001 • 1,033 citations

Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells

2005 • 998 citations

Mechanisms and functional significance of tumour-induced dendritic-cell defects

2004 • 995 citations

Regulatory T Cells Selectively Express Toll-like Receptors and Are Activated by Lipopolysaccharide

2003 • 976 citations

Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors

2005 • 973 citations

Innate Immunity Gone Awry: Linking Microbial Infections to Chronic Inflammation and Cancer

2006 • 917 citations

Spatiotemporal regulation of MyD88–IRF-7 signalling for robust type-I interferon induction

2005 • 886 citations

Human tumor antigens recognized by T lymphocytes.

1996 • 860 citations

Induction and mechanism of action of transforming growth factor‐β‐secreting Th3 regulatory cells

2001 • 856 citations

Origin of regulatory T cells with known specificity for antigen

2002 • 854 citations

Toll-like receptor 2 controls expansion and function of regulatory T cells

2006 • 756 citations

Toll-Like Receptor 8-Mediated Reversal of CD4 ⁺ Regulatory T Cell Function

2005 • 734 citations

In Vivo Instruction of Suppressor Commitment in Naive T Cells

2004 • 726 citations

Recognition of the Peripheral Self by Naturally Arising CD25+ CD4+ T Cell Receptors

2004 • 690 citations

Foxp3 Expressing CD4+CD25high Regulatory T Cells Are Overrepresented in Human Metastatic Melanoma Lymph Nodes and Inhibit the Function of Infiltrating T Cells

2004 • 680 citations

Cyclophosphamide-facilitated adoptive immunotherapy of an established tumor depends on elimination of tumor-induced suppressor T cells.

1982 • 640 citations

Infectious Tolerance

2002 • 614 citations

Toll-Like Receptor 2 Suppresses Immunity against Candida albicans through Induction of IL-10 and Regulatory T Cells

2004 • 601 citations

Inhibition of NF-κB in cancer cells converts inflammation- induced tumor growth mediated by TNFα to TRAIL-mediated tumor regression

2004 • 598 citations

Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter

2005 • 583 citations

Flexibility of Mouse Classical and Plasmacytoid-derived Dendritic Cells in Directing T Helper Type 1 and 2 Cell Development

2003 • 561 citations

Tumor-Specific Human CD4+ Regulatory T Cells and Their Ligands

2004 • 525 citations

At the Crossroads of Inflammation and Cancer

2004 • 496 citations

Human CD4+CD25+ Regulatory, Contact-dependent T Cells Induce Interleukin 10–producing, Contact-independent Type 1-like Regulatory T Cells

2002 • 484 citations

Human CD25+CD4+ T Suppressor Cell Clones Produce Transforming Growth Factor β, but not Interleukin 10, and Are Distinct from Type 1 T Regulatory Cells

2002 • 440 citations

Regulatory T cells under scrutiny

2003 • 427 citations

T-cell-mediated suppression of anti-tumor immunity. An explanation for progressive growth of an immunogenic tumor.

1980 • 373 citations

Human CD4+ T Cells Express TLR5 and Its Ligand Flagellin Enhances the Suppressive Capacity and Expression of FOXP3 in CD4+CD25+ T Regulatory Cells

2005 • 368 citations

Analysis of regulatory CD8 T cells in Qa-1-deficient mice

2004 • 330 citations

The role of different subsets of T regulatory cells in controlling autoimmunity

2000 • 323 citations

Infected site-restricted Foxp3+ natural regulatory T cells are specific for microbial antigens

2006 • 317 citations

Human tumor antigens for cancer vaccine development

1999 • 298 citations

Inability of a Fusion Protein of IL-2 and Diphtheria Toxin (Denileukin Diftitox, DAB389IL-2, ONTAK) to Eliminate Regulatory T Lymphocytes in Patients With Melanoma

2005 • 293 citations

Role for IL-10 in Suppression Mediated by Peptide-Induced Regulatory T Cells In Vivo

2003 • 252 citations

An integrated view of suppressor T cell subsets in immunoregulation

2004 • 248 citations

Control of Foxp3+ CD25+CD4+ regulatory cell activation and function by dendritic cells

2004 • 226 citations

Sequence Variants ofToll-Like Receptor 4Are Associated with Prostate Cancer Risk

2004 • 217 citations

Regulatory T Cell Suppression and Anergy Are Differentially Regulated by Proinflammatory Cytokines Produced by TLR-Activated Dendritic Cells

2004 • 202 citations

Immunity against cancer: lessons learned from melanoma

2001 • 190 citations

Continuous control of autoimmune disease by antigen-dependent polyclonal CD4+CD25+ regulatory T cells in the regional lymph node

2005 • 180 citations

Cutting Edge: Self-Peptides Drive the Peripheral Expansion of CD4+CD25+ Regulatory T Cells

2003 • 177 citations

CD4⁺CD25⁺T cells responding to serologically defined autoantigens suppress antitumor immune responses

2003 • 168 citations

The Specific Regulation Of Immune Responses By CD8⁺T Cells Restricted By The MHC Class Ib Molecule, Qa-1

2000 • 168 citations

Sequence Variants in Toll-Like Receptor Gene Cluster (TLR6-TLR1-TLR10) and Prostate Cancer Risk

2005 • 157 citations

Recognition of a New ARTC1 Peptide Ligand Uniquely Expressed in Tumor Cells by Antigen-Specific CD4+ Regulatory T Cells

2005 • 156 citations

License to Heal: Bidirectional Interaction of Antigen-Specific Regulatory T Cells and Tolerogenic APC

2005 • 147 citations

Qa-1 restriction of CD8+ suppressor T cells

2004 • 142 citations

Definition of target antigens for naturally occurring CD4+ CD25+ regulatory T cells

2005 • 131 citations

Clonal analysis of cytotoxic and regulatory T cell responses against human melanoma.

1989 • 130 citations

The role of stroma in immune recognition and destruction of well-established solid tumors

2006 • 124 citations

Autologous melanoma-induced activation of regulatory T cells that suppress cytotoxic response.

1990 • 75 citations

Regulatory T cells and Toll-like receptors in tumor immunity

2006 • 53 citations

Enhancing antitumor immune responses: intracellular peptide delivery and identification of MHC class II‐restricted tumor antigens

2002 • 49 citations

Reviving suppression?

2004 • 21 citations