Signal transduction by reactive oxygen species

Oxidants, oxidative stress and the biology of ageing

2000 • 8,990 citations

Aging: A Theory Based on Free Radical and Radiation Chemistry

1956 • 8,252 citations

Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

2006 • 5,824 citations

A role for mitochondria in NLRP3 inflammasome activation

2010 • 4,672 citations

Mitochondria, Oxidants, and Aging

2005 • 4,115 citations

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

2010 • 2,658 citations

Premature ageing in mice expressing defective mitochondrial DNA polymerase

2004 • 2,561 citations

Requirement for Generation of H ₂ O ₂ for Platelet-Derived Growth Factor Signal Transduction

1995 • 2,505 citations

Reactive oxygen species have a causal role in multiple forms of insulin resistance

2006 • 2,397 citations

Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1

1998 • 2,360 citations

Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators

2006 • 2,113 citations

Mitochondrial DNA Mutations, Oxidative Stress, and Apoptosis in Mammalian Aging

2005 • 2,025 citations

Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4

2007 • 1,997 citations

Reactive Oxygen Species Promote TNFα-Induced Death and Sustained JNK Activation by Inhibiting MAP Kinase Phosphatases

2005 • 1,727 citations

The p66shc adaptor protein controls oxidative stress response and life span in mammals

1999 • 1,688 citations

Extension of Murine Life Span by Overexpression of Catalase Targeted to Mitochondria

2005 • 1,670 citations

FoxOs Are Critical Mediators of Hematopoietic Stem Cell Resistance to Physiologic Oxidative Stress

2007 • 1,505 citations

Quantitative reactivity profiling predicts functional cysteines in proteomes

2010 • 1,501 citations

A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish

2009 • 1,435 citations

Cellular Defenses against Superoxide and Hydrogen Peroxide

2008 • 1,434 citations

Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing

2005 • 1,425 citations

Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

2003 • 1,353 citations

Specific Aquaporins Facilitate the Diffusion of Hydrogen Peroxide across Membranes

2006 • 1,226 citations

Epidermal Growth Factor (EGF)-induced Generation of Hydrogen Peroxide

1997 • 1,208 citations

Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

2009 • 1,188 citations

Glucose Restriction Extends Caenorhabditis elegans Life Span by Inducing Mitochondrial Respiration and Increasing Oxidative Stress

2007 • 1,155 citations

Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells

2004 • 1,126 citations

Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology

2006 • 1,113 citations

Electron Transfer between Cytochrome c and p66Shc Generates Reactive Oxygen Species that Trigger Mitochondrial Apoptosis

2005 • 1,102 citations

Regulation of JNK signaling by GSTp

1999 • 1,102 citations

The sites and topology of mitochondrial superoxide production

2010 • 1,065 citations

ATM Activation by Oxidative Stress

2010 • 1,009 citations

Reversible Inactivation of Protein-tyrosine Phosphatase 1B in A431 Cells Stimulated with Epidermal Growth Factor

1998 • 968 citations

Thioredoxin-dependent peroxide reductase from yeast.

1994 • 940 citations

Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate

2003 • 930 citations

Redox Regulation of Forkhead Proteins Through a p66shc -Dependent Signaling Pathway

2002 • 810 citations

Nox proteins in signal transduction

2009 • 804 citations

Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)

2011 • 797 citations

Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice

2008 • 782 citations

Circadian clocks in human red blood cells

2011 • 766 citations

Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression

2003 • 756 citations

How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)

2010 • 721 citations

Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation

2005 • 717 citations

Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation

2009 • 692 citations

ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

2010 • 674 citations

Aquaporin-3 mediates hydrogen peroxide uptake to regulate downstream intracellular signaling

2010 • 646 citations

A Mitochondrial Superoxide Signal Triggers Increased Longevity in Caenorhabditis elegans

2010 • 599 citations

Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-α activation

2005 • 597 citations

Inactivation of Peroxiredoxin I by Phosphorylation Allows Localized H2O2 Accumulation for Cell Signaling

2010 • 587 citations

FoxO3 Regulates Neural Stem Cell Homeostasis

2009 • 555 citations

Reactive Oxygen Species Enhance Insulin Sensitivity

2009 • 554 citations

Insulin resistance is a cellular antioxidant defense mechanism

2009 • 506 citations

The NAD(P)H Oxidase Homolog Nox4 Modulates Insulin-Stimulated Generation of H₂O₂ and Plays an Integral Role in Insulin Signal Transduction

2004 • 506 citations

A Palette of Fluorescent Probes with Varying Emission Colors for Imaging Hydrogen Peroxide Signaling in Living Cells

2010 • 491 citations

The isolation and purification of a specific “protector” protein which inhibits enzyme inactivation by a thiol/Fe(III)/O2 mixed-function oxidation system.

1988 • 483 citations

Inhibition of Respiration Extends C. elegans Life Span via Reactive Oxygen Species that Increase HIF-1 Activity

2010 • 480 citations

Deletion of the Mitochondrial Superoxide Dismutase sod-2 Extends Lifespan in Caenorhabditis elegans

2009 • 476 citations

FLP Recombinase-Mediated Induction of Cu/Zn-Superoxide Dismutase Transgene Expression Can Extend the Life Span of Adult Drosophila melanogaster Flies

1999 • 462 citations

Bmi1 regulates mitochondrial function and the DNA damage response pathway

2009 • 456 citations

FoxOs Cooperatively Regulate Diverse Pathways Governing Neural Stem Cell Homeostasis

2009 • 449 citations

p21 as a Common Signaling Target of Reactive Free Radicals and Cellular Redox Stress

1995 • 409 citations

ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair

2010 • 388 citations

Role for Mitochondrial Oxidants as Regulators of Cellular Metabolism

2000 • 387 citations

The thioredoxin-related redox-regulating protein nucleoredoxin inhibits Wnt–β-catenin signalling through Dishevelled

2006 • 354 citations

A Redox-Dependent Pathway for Regulating Class II HDACs and Cardiac Hypertrophy

2008 • 344 citations

Mitochondrial Reactive Oxygen Species Are Obligatory Signals for Glucose-Induced Insulin Secretion

2008 • 335 citations

Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide

2004 • 334 citations

Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity

2009 • 319 citations

Mutations in the selenocysteine insertion sequence–binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans

2010 • 290 citations

Measurement of H2O2 within Living Drosophila during Aging Using a Ratiometric Mass Spectrometry Probe Targeted to the Mitochondrial Matrix

2011 • 286 citations

TRPC channel activation by extracellular thioredoxin

2008 • 278 citations

Molecular Determinants of Selectivity in 5-Hydroxytryptamine1B Receptor-G Protein Interactions

1997 • 277 citations

Regulation of Insulin Signaling through Reversible Oxidation of the Protein-tyrosine Phosphatases TC45 and PTP1B

2004 • 270 citations

Nrf2-ARE stress response mechanism: A control point in oxidative stress-mediated dysfunctions and chronic inflammatory diseases

2010 • 267 citations

The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity

1997 • 258 citations

Inhibition of endogenous thioredoxin in the heart increases oxidative stress and cardiac hypertrophy

2003 • 244 citations

Inhibition of endogenous thioredoxin in the heart increases oxidative stress and cardiac hypertrophy

2003 • 232 citations

Increased oxidative stress in ataxia telangiectasia evidenced by alterations in redox state of brains from Atm-deficient mice.

2001 • 231 citations

Mitochondrial Reactive Oxygen Species Trigger Hypoxia-Inducible Factor-Dependent Extension of the Replicative Life Span during Hypoxia

2007 • 217 citations

Redox Regulation of Nuclear Post-Translational Modifications During NF-κB Activation

2009 • 202 citations

Beobachtungen über die Oxydationsprozesse im Seeigelei.

1908 • 198 citations

Overexpression of Mn Superoxide Dismutase Does Not Increase Life Span in Mice

2009 • 198 citations

Mice Deficient in Both Mn Superoxide Dismutase and Glutathione Peroxidase-1 Have Increased Oxidative Damage and a Greater Incidence of Pathology but No Reduction in Longevity

2009 • 192 citations

High-Throughput Identification of Catalytic Redox-Active Cysteine Residues

2007 • 187 citations

Ataxia-telangiectasia mutated kinase regulates ribonucleotide reductase and mitochondrial homeostasis

2007 • 179 citations

Reactive Oxygen Species Regulate a Slingshot-Cofilin Activation Pathway

2009 • 175 citations

The Major Target of the Endogenously Generated Reactive Oxygen Species in Response to Insulin Stimulation Is Phosphatase and Tensin Homolog and Not Phosphoinositide-3 Kinase (PI-3 Kinase) in the PI-3 Kinase/Akt Pathway

2004 • 171 citations

Elevated Oxidative Stress in Patients with Ataxia Telangiectasia

2002 • 168 citations

Fluorescent probes for nitric oxide and hydrogen peroxide in cell signaling

2007 • 163 citations

Caenorhabditis elegans lifespan extension caused by treatment with an orally active ROS-generator is dependent on DAF-16 and SIR-2.1

2009 • 155 citations

v-Crk Modulation of Growth Factor-induced PC12 Cell Differentiation Involves the Src Homology 2 Domain of v-Crk and Sustained Activation of the Ras/Mitogen-activated Protein Kinase Pathway

1995 • 151 citations

Nox enzymes from fungus to fly to fish and what they tell us about Nox function in mammals

2010 • 148 citations

Prx1 Suppresses Radiation-Induced c-Jun NH2-Terminal Kinase Signaling in Lung Cancer Cells through Interaction with the Glutathione S-Transferase Pi/c-Jun NH2-Terminal Kinase Complex

2006 • 143 citations

S‐glutathiolation by peroxynitrite of p21ras at cysteine‐118 mediates its direct activation and downstream signaling in endothelial cells

2006 • 126 citations

The Oxidative Burst at Fertilization Is Dependent upon Activation of the Dual Oxidase Udx1

2004 • 124 citations

Forkhead Box O as a Sensor, Mediator, and Regulator of Redox Signaling

2010 • 122 citations

Antioxidant N-acetyl cysteine reduces incidence and multiplicity of lymphoma in Atm deficient mice

2006 • 99 citations

Mapping the cysteine proteome: analysis of redox-sensing thiols

2011 • 83 citations

Peroxiredoxin 1 Interacts with Androgen Receptor and Enhances Its Transactivation

2007 • 77 citations

Reactive Oxygen Species-mediated Regulation of Mitochondrial Biogenesis in the Yeast Saccharomyces cerevisiae

2009 • 64 citations

Sending ROS on a Bullet Train

2009 • 27 citations