Mitochondrial Reactive Oxygen Species Trigger Hypoxia-Inducible Factor-Dependent Extension of the Replicative Life Span during Hypoxia

A new mathematical model for relative quantification in real-time RT-PCR

2001 • 32,396 citations

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

1995 • 6,950 citations

Targeting HIF-1 for cancer therapy

2003 • 6,321 citations

The limited in vitro lifetime of human diploid cell strains

1965 • 5,595 citations

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

1997 • 4,870 citations

Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

1998 • 4,845 citations

Activation of Vascular Endothelial Growth Factor Gene Transcription by Hypoxia-Inducible Factor 1

1996 • 3,851 citations

The Free Radical Theory of Aging Matures

1998 • 3,846 citations

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

2000 • 2,052 citations

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

2005 • 1,893 citations

Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

1998 • 1,864 citations

Reactive Oxygen Species Generated at Mitochondrial Complex III Stabilize Hypoxia-inducible Factor-1α during Hypoxia

2000 • 1,860 citations

Reactive Oxygen Species Promote TNFα-Induced Death and Sustained JNK Activation by Inhibiting MAP Kinase Phosphatases

2005 • 1,727 citations

Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts

1997 • 1,582 citations

Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing

2005 • 1,425 citations

Oxidant signals and oxidative stress

2003 • 1,378 citations

ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis

2001 • 1,181 citations

Hypoxia Requires Notch Signaling to Maintain the Undifferentiated Cell State

2005 • 1,076 citations

Reversible Oxidation and Inactivation of Protein Tyrosine Phosphatases In Vivo

2002 • 1,020 citations

Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span

1998 • 1,001 citations

HIF-1 and human disease: one highly involved factor

2000 • 900 citations

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

2002 • 754 citations

Imaging Dynamic Redox Changes in Mammalian Cells with Green Fluorescent Protein Indicators

2004 • 745 citations

Telomerase Maintains Telomere Structure in Normal Human Cells

2003 • 738 citations

Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation

2005 • 717 citations

TELOMERES AND THEIR CONTROL

2000 • 706 citations

Intracellular Signaling by Reactive Oxygen Species during Hypoxia in Cardiomyocytes

1998 • 684 citations

Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization

1998 • 629 citations

Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-α activation

2005 • 597 citations

The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production

2007 • 542 citations

The contribution of VHL substrate binding and HIF1-α to the phenotype of VHL loss in renal cell carcinoma

2002 • 438 citations

Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomerase

1998 • 419 citations

Redox-Dependent Transcriptional Regulation

2005 • 414 citations

Low oxygen concentration extends the lifespan of cultured human diploid cells

1977 • 387 citations

HIF hydroxylation and the mammalian oxygen-sensing pathway

2003 • 313 citations

HIF hydroxylation and the mammalian oxygen-sensing pathway

2003 • 288 citations

c-Src Is Required for Oxidative Stress-mediated Activation of Big Mitogen-activated Protein Kinase 1 (BMK1)

1997 • 270 citations

Suppressing Cancer: The Importance of Being Senescent

2005 • 252 citations

Role of hydrogen peroxide in hypoxia-induced erythropoietin production

1994 • 233 citations

Hypoxia-Inducible Factors 1α and 2α Regulate Trophoblast Differentiation

2005 • 209 citations

Hypoxia-Inducible Factor 1 Mediates Upregulation of Telomerase (hTERT)

2004 • 206 citations

Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain

2001 • 197 citations

SYBR Green real-time telomeric repeat amplification protocol for the rapid quantification of telomerase activity

2002 • 195 citations

Hypoxia Extends the Life Span of Vascular Smooth Muscle Cells through Telomerase Activation

2001 • 174 citations

O ₂ Sensing in the Human Ductus Arteriosus

2002 • 166 citations

HIF1α delays premature senescence through the activation of MIF

2006 • 160 citations

Developmental differences in the immortalization of lung fibroblasts by telomerase

2003 • 157 citations

How to Flip the (Redox) Switch

2002 • 153 citations

Exposure of Yeast Cells to Anoxia Induces Transient Oxidative Stress

2002 • 140 citations

HIF-1-mediated activation of telomerase in cervical cancer cells

2004 • 129 citations

Free radical production in hypoxic pulmonary artery smooth muscle cells

2000 • 119 citations

Systemic hypoxia promotes leukocyte-endothelial adherence via reactive oxidant generation

1999 • 102 citations

The Effect of Low Oxygen Tension on the in Vitro-Replicative Life Span of Human Diploid Fibroblast Cells and Their Transformed Derivatives

1995 • 97 citations

Oxygen Sensing: Getting Pumped by Sterols

2005 • 16 citations