Phagocytosis of Apoptotic Cells by Macrophages From NOD Mice Is Reduced

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages.

1992 • 3,279 citations

Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.

1998 • 3,085 citations

Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies

1998 • 1,431 citations

Apoptosis and Programmed Cell Death in Immunity

1992 • 1,105 citations

Phagocyte recognition of cells undergoing apoptosis

1993 • 1,000 citations

Repeat-induced gene silencing in mammals

1998 • 884 citations

Insulin-Dependent Diabetes Mellitus as an Autoimmune Disease

1994 • 818 citations

A Hierarchical Role for Classical Pathway Complement Proteins in the Clearance of Apoptotic Cells in Vivo

2000 • 733 citations

Complement-dependent Clearance of Apoptotic Cells by Human Macrophages

1998 • 692 citations

The Nonobese Diabetic Mouse as a Model of Autoimmune Diabetes: Immune Dysregulation Gets the NOD

1997 • 685 citations

Type-I Diabetes: A Chronic Autoimmune Disease of Human, Mouse, and Rat

1990 • 650 citations

Programmed Cell Death in the Immune System

1991 • 575 citations

Systemic Exposure to Irradiated Apoptotic Cells Induces Autoantibody Production

1998 • 573 citations

A Laboratory handbook

1989 • 418 citations

Autoantigens as substrates for apoptotic proteases: implications for the pathogenesis of systemic autoimmune disease

1999 • 350 citations

Neutrophil apoptosis is associated with a reduction in CD16 (Fc gamma RIII) expression.

1994 • 333 citations

Phagocytosis of senescent neutrophils by human monocyte-derived macrophages and rabbit inflammatory macrophages.

1982 • 326 citations

Neonatal beta-cell apoptosis: a trigger for autoimmune diabetes?

2000 • 292 citations

Macrophage recruitment during limb development and wound healing in the embryonic and foetal mouse

1994 • 274 citations

NIT-1, a Pancreatic β-Cell Line Established From a Transgenic NOD/Lt Mouse

1991 • 254 citations

Defects in the differentiation and function of antigen presenting cells in NOD/Lt mice.

1993 • 254 citations

Exposure of phosphatidylserine is a general feature in the phagocytosis of apoptotic lymphocytes by macrophages

1999 • 208 citations

Transfection of human pancreatic islets with an anti-apoptotic gene (bcl-2) protects beta-cells from cytokine-induced destruction.

1999 • 204 citations

Apoptosis Is the Mode of β-Cell Death Responsible for the Development of IDDM in the Nonobese Diabetic (NOD) Mouse

1997 • 203 citations

The clearance of apoptotic cells in the liver is mediated by the asialoglycoprotein receptor

1992 • 185 citations

BETA-CELL APOPTOSIS IS RESPONSIBLE FOR THE DEVELOPMENT OF IDDM IN THE MULTIPLE LOW-DOSE STREPTOZOTOCIN MODEL

1996 • 181 citations

Distinct Modes of Macrophage Recognition for Apoptotic and Necrotic Cells Are Not Specified Exclusively by Phosphatidylserine Exposure

2001 • 177 citations

Apoptosis in Autoimmune Diseases.

2001 • 166 citations

NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans.

2000 • 157 citations

NOR/Lt Mice: MHC-Matched Diabetes-Resistant Control Strain for NOD Mice

1992 • 151 citations

Gender differences in some host defense mechanisms

1999 • 125 citations

Aberrant macrophage cytokine production is a conserved feature among autoimmune-prone mouse strains: elevated interleukin (IL)-12 and an imbalance in tumor necrosis factor-alpha and IL-10 define a unique cytokine profile in macrophages from young nonobese diabetic mice.

2000 • 123 citations

Accelerated Nephrotoxic Nephritis Is Exacerbated in C1q-Deficient Mice

2001 • 89 citations

Remnants of suicidal cells fostering systemic autoaggression: Apoptosis in the origin and maintenance of autoimmunity

2000 • 88 citations

Opsonization of Apoptotic Cells: Implications for Uptake and Autoimmunity

2000 • 87 citations

Delayed clearance of apoptotic lymphoma cells allows cross-presentation of intracellular antigens by mature dendritic cells

1999 • 86 citations

Splenic Macrophages From the NOD Mouse Are Defective in the Ability to Present Antigen

1998 • 84 citations

Effects of age, sex and physical exercise on the phagocytic process of murine peritoneal macrophages

1999 • 81 citations

AN APPETITE FOR APOPTOTIC CELLS? CONTROVERSIES AND CHALLENGES

2000 • 66 citations

NOR/Lt mice: MHC-matched diabetes-resistant control strain for NOD mice

1992 • 63 citations

Two Genetic Loci Regulate T Cell–Dependent Islet Inflammation and Drive Autoimmune Diabetes Pathogenesis

2000 • 57 citations

Immune complex processing in C1q-deficient mice

2001 • 56 citations

Apoptosis is the mode of beta-cell death responsible for the development of IDDM in the nonobese diabetic (NOD) mouse

1997 • 54 citations

NIT-1, a pancreatic beta-cell line established from a transgenic NOD/Lt mouse

1991 • 53 citations

Clearance of apoptotic β-cells is reduced in neonatal autoimmune diabetes-prone rats

2002 • 53 citations

An assay for the quantitative measurement of in vitro phagocytosis of early apoptotic thymocytes by murine resident peritoneal macrophages

1999 • 48 citations

Aggregation of macrophages in the tips of intestinal villi in guinea pigs: their possible role in the phagocytosis of effete epithelial cells

1993 • 46 citations

Independent Mechanisms for Macrophage Binding and Macrophage Phagocytosis of Damaged Erythrocytes

1997 • 44 citations

Distribution of Pancreatic Macrophages Preceding and During Early Insulitis in Young NOD Mice

1993 • 25 citations

No constitutive defect in phagocytosis of apoptotic cells by resident peritoneal macrophages from pre-morbid lupus mice

2001 • 24 citations

Characteristics of long-term cultures of proliferating, mononuclear phagocytes from bone marrow.

1983 • 23 citations

Mechanisms underlying the loss of self tolerance in NOD mice

1997 • 11 citations

Cell biology: a laboratory handbook. Volume 1.

1994 • 11 citations

Staining of pancreatic centroacinar cells, liver bile canaliculi and testicular Leydig cells with a monoclonal antibody against adrenocortical cells

1993 • 8 citations

Age-dependent alterations of peritoneal exudate macrophages in autoimmune-prone and autoimmune-resistant mouse strains

1984 • 6 citations