Autoantigens as substrates for apoptotic proteases: implications for the pathogenesis of systemic autoimmune disease

Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages.

1992 • 3,279 citations

Caspases: killer proteases

1997 • 2,440 citations

Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs

1998 • 2,378 citations

Caspases: Intracellular Signaling by Proteolysis

1997 • 2,114 citations

Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis

1994 • 1,969 citations

Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes.

1994 • 1,722 citations

Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies

1998 • 1,431 citations

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells

1994 • 844 citations

Impaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosus

1998 • 825 citations

The role of phosphatidylserine in recognition of apoptotic cells by phagocytes

1998 • 724 citations

Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death.

1996 • 621 citations

Systemic Exposure to Irradiated Apoptotic Cells Induces Autoantibody Production

1998 • 573 citations

Proteolysis of Fodrin (Non-erythroid Spectrin) during Apoptosis

1995 • 539 citations

Surface blebs on apoptotic cells are sites of enhanced procoagulant activity: implications for coagulation events and antigenic spread in systemic lupus erythematosus.

1996 • 485 citations

Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions.

1992 • 447 citations

Specific cleavage of the 70-kDa protein component of the U1 small nuclear ribonucleoprotein is a characteristic biochemical feature of apoptotic cell death.

1994 • 424 citations

The Caspase-3 Precursor Has a Cytosolic and Mitochondrial Distribution: Implications for Apoptotic Signaling

1998 • 419 citations

Lymphocyte-mediated cytotoxicity: Two pathways and multiple effector molecules

1994 • 414 citations

Recognizing death: the phagocytosis of apoptotic cells

1998 • 381 citations

Apoptosis: The importance of being eaten

1998 • 349 citations

Ultraviolet light induces binding of antibodies to selected nuclear antigens on cultured human keratinocytes.

1984 • 334 citations

Modulation of antigen processing by bound antibodies can boost or suppress class II major histocompatibility complex presentation of different T cell determinants.

1995 • 271 citations

Selective cleavage of nuclear autoantigens during CD95 (Fas/APO-1)-mediated T cell apoptosis.

1996 • 270 citations

Processing of engulfed apoptotic bodies yields T cell epitopes.

1997 • 267 citations

How can cryptic epitopes trigger autoimmunity?

1995 • 254 citations

Target Cell Lysis by CTL Granule Exocytosis Is Independent of ICE/Ced-3 Family Proteases

1997 • 237 citations

Genesis and evolution of antichromatin autoantibodies in murine lupus implicates T-dependent immunization with self antigen.

1993 • 234 citations

Hereditary C1q deficiency and systemic lupus erythematosus

1994 • 213 citations

Scleroderma Autoantigens Are Uniquely Fragmented by Metal-catalyzed Oxidation Reactions: Implications for Pathogenesis

1997 • 210 citations

Human cytotoxic lymphocyte granzyme B. Its purification from granules and the characterization of substrate and inhibitor specificity.

1991 • 185 citations

Granule-mediated Killing: Pathways for Granzyme B–initiated Apoptosis

1997 • 178 citations

Ultraviolet light-induced keratinocyte apoptosis: A potential mechanism for the induction of skin lesions and autoantibody production in LE

1997 • 172 citations

Enhanced membrane binding of autoantibodies to cultured keratinocytes of systemic lupus erythematosus patients after ultraviolet B/ultraviolet A irradiation.

1992 • 167 citations

Suppressive effect of antibody on processing of T cell epitopes.

1993 • 166 citations

Immune Clearance of Phosphatidylserine-expressing Cells by Phagocytes

1997 • 148 citations

The inability to process a self-peptide allows autoreactive T cells to escape tolerance.

1993 • 127 citations

Heteronuclear Ribonucleoproteins C1 and C2, Components of the Spliceosome, Are Specific Targets of Interleukin 1β-converting Enzyme-like Proteases in Apoptosis

1996 • 127 citations

Sequential activation of three distinct ICE‐like activities in Fas‐ligated Jurkat cells

1996 • 120 citations

Lupus: Key Pathogenic Mechanisms and Contributing Factors

1995 • 112 citations

Self-peptides in the initiation of lupus autoimmunity.

1995 • 111 citations

CUTANEOUS MANIFESTATIONS OF LUPUS ERYTHEMATOSUS

1994 • 105 citations

Antibodies to the collagen‐like region of C1q in sera of patients with autoimmune rheumatic diseases

1989 • 97 citations

Association of Phosphorylated Serine/Arginine (SR) Splicing Factors With The U1–Small Ribonucleoprotein (snRNP) Autoantigen Complex Accompanies Apoptotic Cell Death

1998 • 91 citations

HIVgp120 activates autoreactive CD4-specific T cell responses by unveiling of hidden CD4 peptides during processing.

1995 • 87 citations

Lamin B autoantibodies in sera of certain patients with systemic lupus erythematosus.

1987 • 81 citations

Dominance and Crypticity of T Cell Antigenic Determinants

1993 • 45 citations

New clues to systemic lupus

1997 • 28 citations

Pathomechanisms of Photosensitive Lupus Erythematosus.

1993 • 25 citations

The Role Of Somatic Mutation In The Pathogenic Anti-DNA Response

1992 • 18 citations

Identification of α-fodrin as a candidate autoantigen in primary Sjögren's syndrome.

1997 • 8 citations

Apoptotic cell clearance in systemic lupus erythematosus: II. Role of β2‐glycoprotein I

1998 • 2 citations

Autoantibodies to RNA polymerase II are common in systemic lupus erythematosus and overlap syndrome. Specific recognition of the phosphorylated (IIO) form by a subset of human sera.

1994 • 2 citations