Unresponsiveness to a self-peptide of mouse lysozyme owing to hindrance of T cell receptor-major histocompatibility complex/peptide interaction caused by flanking epitopic residues.

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

Lymphocyte responses and cytokines

1994 • 1,860 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids.

1985 • 1,650 citations

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

1991 • 1,187 citations

Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity

1990 • 904 citations

Oral Tolerance: Immunologic Mechanisms and Treatment of Animal and Human Organ-Specific Autoimmune Diseases by Oral Administration of Autoantigens

1994 • 895 citations

Dominance and Crypticity of T Cell Antigenic Determinants

1993 • 838 citations

The role of IL-10 in crossregulation of TH1 and TH2 responses

1991 • 775 citations

Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of anti-self (virus) immune response

1991 • 766 citations

Evidence for a differential avidity model of T cell selection in the thymus

1994 • 679 citations

Peripheral Selection of the T Cell Repertoire

1991 • 666 citations

Separation of IL-4 Production from Th Cell Proliferation by an Altered T Cell Receptor Ligand

1991 • 565 citations

Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction

1991 • 523 citations

Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor

1992 • 501 citations

Selective Events in T Cell Development

1994 • 486 citations

Determinant spreading and the dynamics of the autoimmune T-cell repertoire

1993 • 467 citations

Clonal anergy induced in mature Vβ6+ T lymphocytes on immunizing Mls-1b mice with Mls-1a expressing cells

1989 • 462 citations

Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+ T cell subset that inhibits this autoimmune potential.

1993 • 442 citations

Amino acid analysis utilizing phenylisothiocyanate derivatives

1988 • 416 citations

Tickling the TCR: selective T-cell functions stimulated by altered peptide ligands

1993 • 414 citations

A role for non-MHC genetic polymorphism in susceptibility to spontaneous autoimmunity

1994 • 347 citations

A Nondeletional Mechanism of Thymic Self Tolerance

1989 • 322 citations

Identification of the T-cell and Ia contact residues of a T-cell antigenic epitope

1987 • 297 citations

Peptide contributes to the specificity of positive selection of CD8+ T cells in the thymus

1993 • 266 citations

Mouse lysozyme M gene: isolation, characterization, and expression studies.

1988 • 253 citations

Autoimmune diabetes as a consequence of locally produced interleukin-2

1992 • 242 citations

T-cell tolerance by clonal anergy in transgenic mice with nonlymphoid expression of MHC class II I–E

1989 • 238 citations

Positive selection of CD8+ T cells induced by major histocompatibility complex binding peptides in fetal thymic organ culture.

1993 • 221 citations

In vivo competition between self peptides and foreign antigens in T-cell activation

1988 • 216 citations

How some T cells escape tolerance induction

1989 • 216 citations

Antigenic competition at the level of peptide-Ia binding.

1986 • 216 citations

Multi-pin peptide synthesis strategy for T cell determinant analysis

1990 • 174 citations

The CH Series of Murine B Cell Lymphomas: Neoplastic Analogues of Ly‐1⁺ Normal B Cells

1986 • 161 citations

Clonal deletion and clonal anergy in the thymus induced by cellular elements with different radiation sensitivities.

1990 • 146 citations

Determinant capture as a possible mechanism of protection afforded by major histocompatibility complex class II molecules in autoimmune disease.

1993 • 146 citations

Unresponsiveness to a foreign antigen can be caused by self-tolerance

1988 • 134 citations

Capacity of intact proteins to bind to MHC class II molecules.

1989 • 129 citations

Influences of antigen processing on the expression of the T cell repertoire. Evidence for MHC-specific hindering structures on the products of processing.

1988 • 129 citations

The inability to process a self-peptide allows autoreactive T cells to escape tolerance.

1993 • 127 citations

Direct evidence for functional self-protein/Ia-molecule complexes in vivo.

1988 • 111 citations

Failure of clonal deletion in neonatally thymectomized mice: tolerance is preserved through clonal anergy.

1990 • 102 citations

Immunogenicity and tolerogenicity of self-major histocompatibility complex peptides.

1990 • 91 citations

Dominant determinants in hen eggwhite lysozyme correspond to the cryptic determinants within its self-homologue, mouse lysozyme: implications in shaping of the T cell repertoire and autoimmunity.

1993 • 84 citations

Influence of Viral Superantigens on Vβ‐and Vα Specific Positive and Negative Selection

1993 • 83 citations

Sequences outside a minimal immunodominant site exert negative effects on recognition by staphylococcal nuclease-specific T cell clones.

1989 • 68 citations

Oral Tolerance: Immunologic Mechanisms and Treatment of Animal and Human Organ-Specific Autoimmune Diseases by Oral Administration of Autoantigens

1994 • 61 citations

Amino acid residues distinct from the determinant region can profoundly affect activation of T cell clones by related antigens.

1986 • 59 citations

The T Cell Repertoire against Cryptic Self Determinants and Its Involvement in Autoimmunity and Cancer

1994 • 58 citations

A europium fluoroimmunoassay for measuring binding of antigen to class II MHC glycoproteins

1993 • 55 citations

The Molecular Basis of HLA—Disease Association

1989 • 55 citations

Functional recognition of in vivo processed self antigen

1994 • 53 citations

Altered antigen receptor signaling in anergic T cells from self-tolerant T-cell receptor beta-chain transgenic mice.

1991 • 53 citations

Gene complementation. Neither Ir-GLphi gene need be present in the proliferative T cell to generate an immune response to Poly(Glu55Lys36Phe9)n.

1980 • 50 citations

Peripheral tolerance through clonal deletion of mature CD4⁻CD8⁺ T cells

1992 • 49 citations

Hindrance of binding to class II major histocompatibility complex molecules by a single amino acid residue contiguous to a determinant leads to crypticity of the determinant as well as lack of response to the protein antigen.

1995 • 48 citations

Dominance and Crypticity of T Cell Antigenic Determinants

1993 • 45 citations

Selective immunosuppression by administration of major histocompatibility complex (MHC) class II-binding peptides. I. Evidence for in vivo MHC blockade preventing T cell activation.

1992 • 43 citations

The activation of pigeon cytochrome c-specific T cell hybridomas by antigenic peptides is influenced by non-native sequences at the amino terminus of the determinant.

1988 • 41 citations

Constraints in antigen processing result in unresponsiveness to a T cell epitope of hen egg lysozyme in C57BL/6 mice

1992 • 34 citations

Selective in vivo inhibition of T cell activation by class II MHC-binding peptides administered in soluble form.

1990 • 30 citations

Single amino acid substitution alters T cell determinant selection during antigen processing of Staphylococcus aureus nuclease.

1991 • 28 citations

Processing of Self-Proteins and Its Impact on Shaping the T Cell Repertoire, Autoimmunity and Immune Regulation

1993 • 23 citations

The nature of the immune response (Ir) gene defect for pigeon cytochrome c in [B10.A(4R) × B10.PL]F₁ mice

1989 • 20 citations

Determinants of genetic susceptibility in HLA-associated autoimmune disease

1989 • 17 citations

An intracellular self protein synthesized in macrophages is presented but fails to induce tolerance

1989 • 16 citations

A novel form of self tolerance dictated in the thymus of transgenic mice with autoreactive TCR α and β chain genes

1994 • 15 citations

A hole in the T cell repertoire specific for a pigeon cytochrome C related peptide associated with amino acid substitutions on I-A^b molecules

1992 • 14 citations

Inhibition of T Cell Activation by MHC Blockade

1990 • 14 citations