Dominant determinants in hen eggwhite lysozyme correspond to the cryptic determinants within its self-homologue, mouse lysozyme: implications in shaping of the T cell repertoire and autoimmunity.

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids.

1985 • 1,650 citations

Cloning of the mycobacterial epitope recognized by T lymphocytes in adjuvant arthritis

1988 • 838 citations

A Rapid and Sensitive Assay of Muramidase.

1965 • 762 citations

Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction

1991 • 523 citations

Determinant spreading and the dynamics of the autoimmune T-cell repertoire

1993 • 467 citations

Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+ T cell subset that inhibits this autoimmune potential.

1993 • 442 citations

Amino acid analysis utilizing phenylisothiocyanate derivatives

1988 • 416 citations

Prediction of major histocompatibility complex binding regions of protein antigens by sequence pattern analysis.

1989 • 310 citations

Induction of autoreactive B cells allows priming of autoreactive T cells.

1991 • 253 citations

Mouse lysozyme M gene: isolation, characterization, and expression studies.

1988 • 253 citations

Mechanisms influencing the immunodominance of T cell determinants.

1988 • 227 citations

How some T cells escape tolerance induction

1989 • 216 citations

Recognition of a mycobacteria-specific epitope in the 65-kD heat-shock protein by synovial fluid-derived T cell clones.

1990 • 168 citations

T cell determinant structure: cores and determinant envelopes in three mouse major histocompatibility complex haplotypes.

1991 • 138 citations

The inability to process a self-peptide allows autoreactive T cells to escape tolerance.

1993 • 127 citations

Molecular Mimicry as a Mechanism for the Cause and as a Probe Uncovering Etiologic Agent(s) of Autoimmune Disease

1989 • 119 citations

Peptide recognition, T cell receptor usage and HLA restriction elements of human heat‐shock protein (hsp) 60 and mycobacterial 65‐kDa hsp‐reactive T cell clones from rheumatoid synovial fluid

1992 • 118 citations

Direct evidence for functional self-protein/Ia-molecule complexes in vivo.

1988 • 111 citations

Negative Selection of Precursor Thymocytes Before their Differentiation into CD4 ⁺ CD8 ⁺ Cells

1992 • 109 citations

Immunogenicity and tolerogenicity of self-major histocompatibility complex peptides.

1990 • 91 citations

Direct evidence that a class II molecule and a simple globular protein generate multiple determinants.

1985 • 84 citations

The T cell repertoire to a multideterminant antigen. Clonal heterogeneity of the T cell response, variation between syngeneic individuals, and in vitro selection of T cell specificities.

1990 • 53 citations

The choice between two distinct T cell determinants within a 23-amino acid region of lysozyme depends on their structural context.

1986 • 48 citations

Restricted T cell receptor expression by human T cell clones specific for mycobacterial 65‐kDa heat‐shock protein: Selective in vivo expansion of T cells bearing defined receptors

1993 • 42 citations

T cells that recognize peptide sequences of self MHC class II molecules exist in syngeneic mice.

1991 • 42 citations

Mouse Lysozyme Production by a Monocytoma: Isolation and Comparison with Other Lysozymes

1970 • 31 citations

Single amino acid substitution alters T cell determinant selection during antigen processing of Staphylococcus aureus nuclease.

1991 • 28 citations

An intracellular self protein synthesized in macrophages is presented but fails to induce tolerance

1989 • 16 citations