Oncogenic transformation induced by the p110β, -γ, and -δ isoforms of class I phosphoinositide 3-kinase

High Frequency of Mutations of the PIK3CA Gene in Human Cancers

2004 • 3,304 citations

Phosphoinositide 3-kinases: A conserved family of signal transducers

1997 • 944 citations

Impaired B and T Cell Antigen Receptor Signaling in p110δ PI 3-Kinase Mutant Mice

2002 • 910 citations

Signaling by Distinct Classes of Phosphoinositide 3-Kinases

1999 • 861 citations

Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic

2005 • 813 citations

PI3K in lymphocyte development, differentiation and activation

2003 • 739 citations

Structure and function of phosphoinositide 3-kinases

1998 • 666 citations

Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation.

1996 • 568 citations

The Gβγ Sensitivity of a PI3K Is Dependent upon a Tightly Associated Adaptor, p101

1997 • 549 citations

Regulation of the p85/p110 Phosphatidylinositol 3′-Kinase: Stabilization and Inhibition of the p110α Catalytic Subunit by the p85 Regulatory Subunit

1998 • 508 citations

Oncogenic Mutations of PIK3CA in Human Cancers

2004 • 502 citations

New procedure for DNA transfection with polycation and dimethyl sulfoxide.

1984 • 481 citations

PI 3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity.

1994 • 450 citations

Consequences of widespread deregulation of the c-myc gene in transgenic mice: Multiple neoplasms and normal development

1986 • 427 citations

p110δ, a novel phosphoinositide 3-kinase in leukocytes

1997 • 417 citations

Transformation of Chicken Cells by the Gene Encoding the Catalytic Subunit of PI 3-Kinase

1997 • 414 citations

Phosphoinositide 3-kinase signalling – which way to target?

2003 • 412 citations

The oncogenic properties of mutant p110α and p110β phosphatidylinositol 3-kinases in human mammary epithelial cells

2005 • 315 citations

When is a lipid kinase not a lipid kinase? When it is a protein kinase

1995 • 315 citations

Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts

2002 • 314 citations

Bifurcation of Lipid and Protein Kinase Signals of PI3Kγ to the Protein Kinases PKB and MAPK

1998 • 310 citations

A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt

2000 • 296 citations

The Akt kinase: Molecular determinants of oncogenicity

1998 • 294 citations

Molecular Balance between the Regulatory and Catalytic Subunits of Phosphoinositide 3-Kinase Regulates Cell Signaling and Survival

2002 • 284 citations

The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis

2005 • 278 citations

ATM-related genes: What do they tell us about functions of the human gene?

1995 • 276 citations

Essential role for the p110 isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia

2005 • 248 citations

p110δ, a Novel Phosphatidylinositol 3-Kinase Catalytic Subunit That Associates with p85 and Is Expressed Predominantly in Leukocytes

1997 • 243 citations

Roles of Gβγ in membrane recruitment and activation of p110γ/p101 phosphoinositide 3-kinase γ

2002 • 237 citations

The phosphatidylinositol 3-kinase serine kinase phosphorylates IRS-1. Stimulation by insulin and inhibition by Wortmannin.

1994 • 234 citations

Genetic Alterations and Aberrant Expression of Genes Related to the Phosphatidyl‐lnositol‐3′‐Kinase/Protein Kinase B (Akt) Signal Transduction Pathway in Glioblastomas

2003 • 233 citations

Characteristics of two new avian tumor virus subgroups

1969 • 227 citations

Roles of Non-catalytic Subunits in Gβγ-induced Activation of Class I Phosphoinositide 3-Kinase Isoforms β and γ

1999 • 220 citations

New Procedure for DNA Transfection with Polycation and Dimethyl Sulfoxide

1984 • 217 citations

Targeted c-myc gene expression in mammary glands of transgenic mice induces mammary tumours with constitutive milk protein gene transcription.

1988 • 196 citations

A Novel Role for Phosphatidylinositol 3-Kinase β in Signaling from G Protein-coupled Receptors to Akt

2000 • 195 citations

Gβγ Stimulates Phosphoinositide 3-Kinase-γ by Direct Interaction with Two Domains of the Catalytic p110 Subunit

1998 • 191 citations

Efficient transformation of chicken embryo fibroblasts by c-Jun requires structural modification in coding and noncoding sequences.

1990 • 175 citations

Direct Effects of Caffeine and Theophylline on p110δ and Other Phosphoinositide 3-Kinases

2002 • 151 citations

Regulation of breast cancer cell chemotaxis by the phosphoinositide 3-kinase p110delta.

2003 • 145 citations

A specific function for phosphatidylinositol 3-kinase α (p85α-p110α) in cell survival and for phosphatidylinositol 3-kinase β (p85α-p110β) in de novo DNA synthesis of human colon carcinoma cells

2000 • 132 citations

Protein kinase activity of phosphoinositide 3-kinase regulates β-adrenergic receptor endocytosis

2005 • 123 citations

Lipid kinase and protein kinase activities of G-protein-coupled phosphoinositide 3-kinase γ: structure–activity analysis and interactions with wortmannin

1997 • 102 citations

Autophosphorylation of p110delta phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases invitro and invivo

1999 • 99 citations

Insulin receptor substrate 1 is phosphorylated by the serine kinase activity of phosphatidylinositol 3-kinase

1994 • 95 citations

Functional studies of the PI(3)-kinase signalling pathway employing synthetic and expressed siRNA

2003 • 92 citations

Activation Loop Sequences Confer Substrate Specificity to Phosphoinositide 3-Kinase α (PI3Kα)

2001 • 88 citations

Telomerase RNA Mutated in Autosomal Dyskeratosis Congenita Reconstitutes a Weakly Active Telomerase Enzyme Defective in Telomere Elongation

2005 • 87 citations

Phosphatidylinositol 3-kinase γ mediates shear stress-dependent activation of JNK in endothelial cells

1998 • 87 citations

The Catalytic Subunit of Phosphoinositide 3-Kinase: Requirements for Oncogenicity

2000 • 85 citations

Phosphorylation of PDE3B by Phosphatidylinositol 3-Kinase Associated with the Insulin Receptor

2000 • 73 citations

Regulation of Phosphoinositide 3-Kinase by Its Intrinsic Serine Kinase Activity In Vivo

2004 • 64 citations

Comparison of the kinetic properties of the lipid- and protein-kinase activities of the p110α and p110β catalytic subunits of class-Ia phosphoinositide 3-kinases

2000 • 59 citations

Identification and Characterization of the Autophosphorylation Sites of Phosphoinositide 3-Kinase Isoforms β and γ

2003 • 55 citations

BCR-ABL Regulates Phosphatidylinositol 3-Kinase-p110γ Transcription and Activation and Is Required for Proliferation and Drug Resistance

2005 • 54 citations

Cloning, expression, purification, and characterization of the human Class Ia phosphoinositide 3-kinase isoforms

2004 • 42 citations

Specific role for p85/p110β in GTP-binding-protein-mediated activation of Akt

2005 • 39 citations

Membrane localization of all class I PI 3‐kinase isoforms suppresses c‐Myc‐induced apoptosis in Rat1 fibroblasts via Akt

2005 • 34 citations

Gene-targeting reveals physiological roles and complex regulation of the phosphoinositide 3-kinases

2003 • 32 citations

Expression of c-MYC under the control of GATA-1 regulatory sequences causes erythroleukemia in transgenic mice.

1995 • 30 citations

Retinoic acid induces selective expression of phosphoinositide 3-kinase gamma in myelomonocytic U937 cells.

1999 • 27 citations

Over‐expression of the p110β but not p110α isoform of PI 3‐kinase inhibits motility in breast cancer cells

2004 • 25 citations

Differential Regulation of Lipid and Protein Kinase Activities of Phosphoinositide 3-Kinase γ in Vitro

1999 • 20 citations

eIF4E binding protein 1 and H-Ras are novel substrates for the protein kinase activity of class-I phosphoinositide 3-kinase

2004 • 18 citations

Cloning, expression, purification and characterization of the human class Ia phosphoinositide 3-kinase isoforms.

2004 • 14 citations