HRX Leukemic Fusion Proteins Form a Heterocomplex with the Leukemia-associated Protein SET and Protein Phosphatase 2A

A novel genetic system to detect protein–protein interactions

1989 • 6,022 citations

The two-hybrid system: a method to identify and clone genes for proteins that interact with a protein of interest.

1991 • 1,489 citations

Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system.

1987 • 1,087 citations

Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate.

1994 • 1,032 citations

Virus induction of human IFNβ gene expression requires the assembly of an enhanceosome

1995 • 994 citations

Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias

1992 • 944 citations

Altered Hox expression and segmental identity in Mll-mutant mice

1995 • 871 citations

The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene

1992 • 850 citations

The A.T-DNA-binding domain of mammalian high mobility group I chromosomal proteins. A novel peptide motif for recognizing DNA structure.

1990 • 674 citations

Xenopus embryos regulate the nuclear localization of XMyoD.

1994 • 648 citations

Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias.

1991 • 602 citations

Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A

1990 • 586 citations

Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours

1995 • 575 citations

An Mll–AF9 Fusion Gene Made by Homologous Recombination Causes Acute Leukemia in Chimeric Mice: A Method to Create Fusion Oncogenes

1996 • 534 citations

The Myeloid Leukemia-associated Protein SET Is a Potent Inhibitor of Protein Phosphatase 2A

1996 • 463 citations

Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains

1995 • 422 citations

Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL

1997 • 416 citations

Deregulation of a Homeobox Gene, HOX11, by the t(10;14) in T Cell Leukemia

1991 • 411 citations

Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene.

1992 • 392 citations

Cellular interactions in development : a practical approach

1993 • 373 citations

MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3)

1997 • 323 citations

Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias

1996 • 312 citations

Tumor Promotion by Inhibitors of ProteinZ Phosphatases 1 and 2A: The Okadaic Acid Class of Compounds

1993 • 310 citations

Reversal of intrinsic DNA bends in the IFNβ gene enhancer by transcription factors and the architectural protein HMG I(Y)

1995 • 280 citations

Okadaic acid, a potent inhibitor of type 1 and type 2A protein phosphatases, activates cdc2/H1 kinase and transiently induces a premature mitosis-like state in BHK21 cells.

1990 • 280 citations

Drosophila NAP-1 Is a Core Histone Chaperone That Functions in ATP-Facilitated Assembly of Regularly Spaced Nucleosomal Arrays

1996 • 253 citations

HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24.

1991 • 252 citations

Alternative processing of mRNAs encoding mammalian chromosomal high-mobility-group proteins HMG-I and HMG-Y.

1989 • 241 citations

11q23 translocations split the "AT-hook" cruciform DNA-binding region and the transcriptional repression domain from the activation domain of the mixed-lineage leukemia (MLL) gene.

1994 • 241 citations

The t(11;16)(q23;p13) Translocation in Myelodysplastic Syndrome Fuses the MLL Gene to the CBP Gene

1997 • 240 citations

The Drosophila snr1 and brm proteins are related to yeast SWI/SNF proteins and are components of a large protein complex.

1995 • 225 citations

Association of protein phosphatase 2A with polyoma virus medium tumor antigen.

1990 • 221 citations

Purification and Characterization of Two Potent Heat-Stable Protein Inhibitors of Protein Phosphatase 2A from Bovine Kidney

1995 • 214 citations

Molecular basis of IIq23 rearrangements in hematopoietic malignant proliferations

1995 • 211 citations

Nucleosome Core Displacement in Vitro via a Metastable Transcription Factor-Nucleosome Complex

1992 • 198 citations

HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint

1997 • 195 citations

Replication factor encoded by a putative oncogene, set, associated with myeloid leukemogenesis.

1995 • 173 citations

Identification and characterization of SET, a nuclear phosphoprotein encoded by the translocation break point in acute undifferentiated leukemia.

1994 • 171 citations

HRX involvement in de novo and secondary leukemias with diverse chromosome 11q23 abnormalities [see comments]

1993 • 166 citations

Separation of PP2A Core Enzyme and Holoenzyme with Monoclonal Antibodies against the Regulatory A Subunit: Abundant Expression of Both Forms in Cells

1997 • 164 citations

TFG3/TAF30/ANC1, a Component of the Yeast SWI/SNF Complex That Is Similar to the Leukemogenic Proteins ENL and AF-9

1996 • 158 citations

Relocation of the carboxyterminal part of CAN from the nuclear envelope to the nucleus as a result of leukemia-specific chromosome rearrangements.

1995 • 156 citations

Differential methylation and altered conformation of cytoplasmic and nuclear forms of protein phosphatase 2A during cell cycle progression.

1995 • 149 citations

Epstein-Barr virus nuclear protein 2 (EBNA2) binds to a component of the human SNF-SWI complex, hSNF5/Ini1

1996 • 142 citations

ENL, the gene fused with HRX in t(11;19) leukemias, encodes a nuclear protein with transcriptional activation potential in lymphoid and myeloid cells

1994 • 132 citations

EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia

1997 • 125 citations

trithorax regulates multiple homeotic genes in the bithorax and Antennapedia complexes and exerts different tissue-specific, parasegment-specific and promoter-specific effects on each

1993 • 119 citations

Stimulation of Transcription Factor Binding and Histone Displacement by Nucleosome Assembly Protein 1 and Nucleoplasmin Requires Disruption of the Histone Octamer

1995 • 114 citations

HMGI(Y) expression in human uterine leiomyomata. Involvement of another high-mobility group architectural factor in a benign neoplasm.

1997 • 100 citations

Interleukin-11 acts as an autocrine growth factor for human megakaryoblastic cell lines

1993 • 94 citations

Mutagenesis by incorporation of a phosphorylated oligo during PCR amplification.

1994 • 91 citations

Substrate Structure Influences Binding of the Non-Histone Protein HMG-I(Y) to Free and Nucleosomal DNA

1996 • 72 citations

Self-fusion of the ALL 1 Gene

1995 • 72 citations

Double knockout of the ALL-1 gene blocks hematopoietic differentiation in vitro.

1996 • 71 citations

The role of brahma and related proteins in transcription and development

1995 • 71 citations

A Protein which Facilitates Assembly of Nucleosome-Iike Structures In Vitro in Mammalian Cells1

1983 • 71 citations

Complete exon structure of the ALL1 gene.

1996 • 68 citations

Nucleic acid binding and intracellular localization of unr, a protein with five cold shock domains

1994 • 67 citations

Misexpression of disrupted HMGI architectural factors activates alternative pathways of tumorigenesis.

1997 • 57 citations

A specific deletion in the breakpoint cluster region of the ALL-1 gene is associated with acute lymphoblastic T-cell leukemias.

1996 • 50 citations

The localization of the HRX/ALL1 protein to specific nuclear subdomains is altered by fusion with its eps15 translocation partner.

1997 • 40 citations

Identification of MLL and chimeric MLL gene products involved in 11q23 translocation and possible mechanisms of leukemogenesis by MLL truncation.

1996 • 36 citations

Protein complexes for remodeling chromatin

1997 • 34 citations

The Mixed Lineage Leukemia (MLL) Protein Involved in 11 q23 Translocations Contains a Domain that Binds Cruciform DNA and Scaffold Attachment Region (SAR) DNA

1996 • 31 citations

Variability of 11q23 rearrangements in hematopoietic cell lines identified with fluorescence in situ hybridization

1993 • 25 citations

Chromosome abnormalities in leukaemia: the 11q23 paradigm.

1996 • 25 citations

ALL-1 interacts with unr, a protein containing multiple cold shock domains.

1996 • 15 citations