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1992 • 1,198 citations

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Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase.

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1998 • 248 citations

Immunohistochemical Quantitation of Thymidylate Synthase Expression in Colorectal Cancer Metastases Predicts for Clinical Outcome to Fluorouracil-Based Chemotherapy

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Novel mechanism(s) of resistance to 5-fluorouracil in human colon cancer (HCT-8) sublines following exposure to two different clinically relevant dose schedules.

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Thymidylate synthase inhibitors in cancer therapy: direct and indirect inhibitors.

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Thymidylate synthase protein expression in primary colorectal cancer compared with the corresponding distant metastases and relationship with the clinical response to 5-fluorouracil.

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Thymidylate synthase is a predictor for response and resistance in hepatic artery infusion chemotherapy

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Synergism and Lack of Cross-resistance Between Short-term and Continuous Exposure to Fluorouracil in Human Colon Adenocarcinoma Cells

1993 • 82 citations

Increased levels of thymidylate synthetase in cells exposed to 5-fluorouracil.

1984 • 80 citations

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Colorectal liver metastasis thymidylate synthase staining correlates with response to hepatic arterial floxuridine.

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Schedule-selective biochemical modulation of 5-fluorouracil: a phase II study in advanced colorectal cancer.

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Changes in Thymidylate Synthase mRNA in Blood Leukocytes from Patients with Colorectal Cancer after Bolus Administration of 5-Fluorouracil

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