Colorectal liver metastasis thymidylate synthase staining correlates with response to hepatic arterial floxuridine.

Fluorouracil: biochemistry and pharmacology.

1988 • 825 citations

Assessment of response to therapy in advanced breast cancer

1977 • 705 citations

Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors.

1995 • 668 citations

Quality of life and survival with continuous hepatic-artery floxuridine infusion for colorectal liver metastases

1994 • 538 citations

A clinical-pharmacological evaluation of hepatic arterial infusions of 5-fluoro-2'-deoxyuridine and 5-fluorouracil.

1978 • 516 citations

Fisher's Exact Test

1992 • 507 citations

The role of thymidylate synthase expression in prognosis and outcome of adjuvant chemotherapy in patients with rectal cancer.

1994 • 416 citations

Randomized comparison of two schedules of fluorouracil and leucovorin in the treatment of advanced colorectal cancer.

1994 • 316 citations

Quantitation of thymidylate synthase, dihydrofolate reductase, and DT-diaphorase gene expression in human tumors using the polymerase chain reaction.

1992 • 248 citations

Thymidylate synthase and drug resistance

1995 • 154 citations

Quantitation of intratumoral thymidylate synthase expression predicts for resistance to protracted infusion of 5-fluorouracil and weekly leucovorin in disseminated colorectal cancers: Preliminary report from an ongoing trial

1995 • 130 citations

Production and characterization of monoclonal antibodies that localize human thymidylate synthase in the cytoplasm of human cells and tissue.

1991 • 123 citations

Biochemical determinants of tumor sensitivity to 5-fluorouracil: Ultrasensitive methods for the determination of 5-fluoro-2′-deoxyuridylate, 2′-deoxyuridylate, and thymidylate synthetase

1979 • 121 citations

Thymidylate synthase gene amplification in fluorodeoxyuridine-resistant mouse cell lines.

1985 • 70 citations

Induction of thymidylate synthase associated with multidrug resistance in human breast and colon cancer cell lines.

1991 • 67 citations

Mechanisms of resistance to fluoropyrimidines.

1992 • 39 citations

Fluorodeoxyuridine uptake by human colorectal hepatic metastases after hepatic artery infusion.

1986 • 34 citations

Predictive value of thymidylate synthase and dihydropyrimidine dehydrogenase

1994 • 31 citations

Measurement of response to treatment in colorectal liver metastases

1995 • 27 citations

Hepatic arterial floxuridine as second-line treatment for systemic fluorouracil-resistant colorectal liver metastases

1998 • 21 citations

Variation in human thymidylate synthase is associated with resistance to 5-fluoro-2'-deoxyuridine.

1993 • 11 citations

Thymidylate Synthase in Advanced Gastrointestinal and Breast Cancers

1996 • 11 citations

Thymidylate synthase levels in tumor biopsies from patients with colorectal cancer.

1994 • 7 citations