Immunohistochemical Quantitation of Thymidylate Synthase Expression in Colorectal Cancer Metastases Predicts for Clinical Outcome to Fluorouracil-Based Chemotherapy

A Comparative Study of the Peroxidase-antiperoxidase Method and an Avidin-Biotin Complex Method for Studying Polypeptide Hormones with Radioimmunoassay Antibodies

1981 • 1,664 citations

Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: evidence in terms of response rate. Advanced Colorectal Cancer Meta-Analysis Project.

1992 • 1,198 citations

Randomized trial comparing monthly low-dose leucovorin and fluorouracil bolus with bimonthly high-dose leucovorin and fluorouracil bolus plus continuous infusion for advanced colorectal cancer: a French intergroup study.

1997 • 912 citations

A prospective randomized comparison of continuous infusion fluorouracil with a conventional bolus schedule in metastatic colorectal carcinoma: a Mid-Atlantic Oncology Program Study.

1989 • 781 citations

Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors.

1995 • 668 citations

Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer response and resistance to protracted-infusion fluorouracil and weekly leucovorin.

1997 • 484 citations

Two consecutive phase II studies of oxaliplatin (L-OHP) for treatment of patients with advanced colorectal carcinoma who were resistant to previous treatment with fluoropyrimidines

1996 • 439 citations

Phase II study of irinotecan in the treatment of advanced colorectal cancer in chemotherapy-naive patients and patients pretreated with fluorouracil-based chemotherapy.

1997 • 434 citations

The role of thymidylate synthase expression in prognosis and outcome of adjuvant chemotherapy in patients with rectal cancer.

1994 • 416 citations

Oxaliplatin with high-dose leucovorin and 5-fluorouracil 48-hour continuous infusion in pretreated metastatic colorectal cancer

1997 • 388 citations

Autoregulation of human thymidylate synthase messenger RNA translation by thymidylate synthase.

1991 • 375 citations

Phase II trial of irinotecan in patients with progressive or rapidly recurrent colorectal cancer.

1996 • 360 citations

Irinotecan is an active agent in untreated patients with metastatic colorectal cancer.

1996 • 340 citations

Fluorouracil in colorectal cancer--a tale of two drugs: implications for biochemical modulation.

1997 • 340 citations

Quantitation of thymidylate synthase, dihydrofolate reductase, and DT-diaphorase gene expression in human tumors using the polymerase chain reaction.

1992 • 248 citations

Phase II trial of uracil and tegafur plus oral leucovorin: an effective oral regimen in the treatment of metastatic colorectal carcinoma.

1994 • 208 citations

Novel mechanism(s) of resistance to 5-fluorouracil in human colon cancer (HCT-8) sublines following exposure to two different clinically relevant dose schedules.

1992 • 195 citations

Thymidylate synthase inhibitors in cancer therapy: direct and indirect inhibitors.

1997 • 193 citations

Thymidylate synthase inhibition after administration of fluorouracil with or without leucovorin in colon cancer patients: implications for treatment with fluorouracil.

1994 • 191 citations

Phase II study of hepatic arterial floxuridine, leucovorin, and dexamethasone for unresectable liver metastases from colorectal carcinoma.

1994 • 177 citations

Thymidylate synthase overproduction and gene amplification in fluorodeoxyuridine-resistant human cells.

1985 • 154 citations

Prognostic factors in advanced colorectal carcinoma

1983 • 144 citations

ZD1694: A novel thymidylate synthase inhibitor with substantial activity in the treatment of patients with advanced colorectal cancer. Tomudex Colorectal Study Group.

1996 • 128 citations

Production and characterization of monoclonal antibodies that localize human thymidylate synthase in the cytoplasm of human cells and tissue.

1991 • 123 citations

Biochemical determinants of 5-fluorouracil response in vivo. The role of deoxyuridylate pool expansion.

1975 • 121 citations

Prognostic variables in patients with hepatic metastases from colorectal cancer. Importance of medical assessment of liver involvement

1989 • 112 citations

Higher levels of thymidylate synthase gene expression are observed in pulmonary as compared with hepatic metastases of colorectal adenocarcinoma.

1998 • 112 citations

Lack of correlation between thymidylate synthase levels in primary colorectal tumours and subsequent response to chemotherapy

1997 • 101 citations

p53 mutations as a possible predictor of response to chemotherapy in metastatic colorectal carcinomas

1996 • 99 citations

Thymidylate synthase gene amplification in a colon tumor resistant to fluoropyrimidine chemotherapy.

1987 • 84 citations

p53 nuclear protein overexpression in colorectal cancer: a dominant predictor of survival in patients with advanced hepatic metastases.

1996 • 79 citations

Mechanisms of sensitivity and resistance of murine tumors to 5-fluorouracil.

1980 • 71 citations

Induction of thymidylate synthase associated with multidrug resistance in human breast and colon cancer cell lines.

1991 • 67 citations

Decreased folylpolyglutamate synthetase expression: a novel mechanism of fluorouracil resistance.

1993 • 63 citations

High-Level Expression of Human Thymidylate Synthase

1997 • 59 citations

Prolonged Continuous Infusion of Fluorouracil With Weekly Bolus Leucovorin: A Phase II Study in Patients With Disseminated Colorectal Cancer

1993 • 55 citations

Bcl-2 expression and response to chemotherapy in colorectal adenocarcinomas

1997 • 47 citations

Modulation of high-dose infusional fluorouracil by low-dose methotrexate in patients with advanced or metastatic colorectal cancer: final results of a randomized European Organization for Research and Treatment of Cancer Study.

1996 • 44 citations

Isolation and Characterization of Thymitaq (AG337) and 5-Fluoro-2-deoxyuridylate-resistant Mutants of Human Thymidylate Synthase from Ethyl Methanesulfonate-exposed Human Sarcoma HT1080 Cells

1998 • 43 citations

Schedule-selective biochemical modulation of 5-fluorouracil: a phase II study in advanced colorectal cancer.

1995 • 33 citations

Colorectal cancer—Is there an alternative to 5-FU?

1997 • 30 citations

Schedule-selective biochemical modulation of 5-fluorouracil in advanced colorectal cancer: a multicentric phase II study

1998 • 11 citations

High-dose infusional 5-FU in the treatment of advanced colorectal cancer: a summary of the European experience.

1996 • 4 citations

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