Distinct modes of ATR activation after replication stress and DNA double-strand breaks in Caenorhabditis elegans

A comprehensive analysis of protein–protein interactions in Saccharomyces cerevisiae

2000 • 4,734 citations

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

2003 • 3,385 citations

Cell-cycle checkpoints and cancer

2004 • 2,699 citations

Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes

2003 • 2,569 citations

ATM and related protein kinases: safeguarding genome integrity

2003 • 2,516 citations

Cell cycle checkpoint signaling through the ATM and ATR kinases

2001 • 1,962 citations

ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex

2005 • 1,364 citations

The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response

1998 • 1,220 citations

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

2005 • 1,209 citations

ATR and ATRIP: Partners in Checkpoint Signaling

2001 • 935 citations

ATR disruption leads to chromosomal fragmentation and early embryonic lethality

2000 • 922 citations

A splicing mutation affecting expression of ataxia–telangiectasia and Rad3–related protein (ATR) results in Seckel syndrome

2003 • 767 citations

The DNA replication checkpoint response stabilizes stalled replication forks

2001 • 740 citations

Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint

2001 • 654 citations

The C. elegans Protein EGL-1 Is Required for Programmed Cell Death and Interacts with the Bcl-2–like Protein CED-9

1998 • 628 citations

Loss of the Putative RNA-Directed RNA Polymerase RRF-3 Makes C. elegans Hypersensitive to RNAi

2002 • 577 citations

Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex

1999 • 533 citations

Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints

1998 • 533 citations

A Conserved Checkpoint Pathway Mediates DNA Damage–Induced Apoptosis and Cell Cycle Arrest in C. elegans

2000 • 506 citations

DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?

2001 • 494 citations

Caenorhabditis elegans p53: Role in Apoptosis, Meiosis, and Stress Resistance

2001 • 457 citations

The Nuclease Activity of Mre11 Is Required for Meiosis but Not for Mating Type Switching, End Joining, or Telomere Maintenance

1999 • 443 citations

Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice

2000 • 425 citations

Synapsis-dependent and -independent mechanisms stabilize homolog pairing during meiotic prophase in C. elegans

2002 • 383 citations

ATR and ATM regulate the timing of DNA replication origin firing

2004 • 375 citations

The C. elegans homolog of the p53 tumor suppressor is required for DNA damage-induced apoptosis

2001 • 355 citations

MRT-2 checkpoint protein is required for germline immortality and telomere replication in C. elegans

2000 • 308 citations

The Cdc7 protein kinase is required for origin firing during S phase

1998 • 282 citations

Combined Functional Genomic Maps of the C. elegans DNA Damage Response

2002 • 279 citations

Caenorhabditis elegans HUS-1 Is a DNA Damage Checkpoint Protein Required for Genome Stability and EGL-1-Mediated Apoptosis

2002 • 271 citations

Cdc7p-Dbf4p kinase binds to chromatin during S phase and is regulated by both the APC and the RAD53 checkpoint pathway

1999 • 267 citations

ATRIP Binding to Replication Protein A-Single-stranded DNA Promotes ATR–ATRIP Localization but Is Dispensable for Chk1 Phosphorylation

2005 • 229 citations

Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control

1998 • 228 citations

A Novel mre11 Mutation Impairs Processing of Double-Strand Breaks of DNA during Both Mitosis and Meiosis

1998 • 220 citations

Translational Repression of C. elegans p53 by GLD-1 Regulates DNA Damage-Induced Apoptosis

2005 • 214 citations

Apoptosis

2001 • 177 citations

Seckel syndrome exhibits cellular features demonstrating defects in the ATR-signalling pathway

2004 • 173 citations

RAD-51-Dependent and -Independent Roles of a Caenorhabditis elegans BRCA2-Related Protein during DNA Double-Strand Break Repair

2005 • 166 citations

Differential Activation of the DNA Replication Checkpoint Contributes to Asynchrony of Cell Division in C. elegans Embryos

2003 • 163 citations

C. elegans RAD-5/CLK-2 defines a new DNA damage checkpoint protein

2001 • 163 citations

C. elegans mre-11 is required for meiotic recombination and DNA repair but is dispensable for the meiotic G₂ DNA damage checkpoint

2001 • 152 citations

BRCA1/BARD1 Orthologs Required for DNA Repair in Caenorhabditis elegans

2004 • 144 citations

Mre11 Assembles Linear DNA Fragments into DNA Damage Signaling Complexes

2004 • 107 citations

CDC7/DBF4 Functions in the Translesion Synthesis Branch of the RAD6 Epistasis Group in Saccharomyces cerevisiae

2004 • 63 citations

Characterization of Ce-atl-1, an ATM-like gene from Caenorhabditis elegans

2000 • 21 citations

Deleted Work

1955 • 0 citations