The Rev Protein of Human Immunodeficiency Virus Type 1 Promotes Polysomal Association and Translation of gag/pol and vpu/env mRNAs

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Enzymatic Amplification of β-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia

1985 • 9,128 citations

Current protocols in molecular biology

1988 • 4,543 citations

Firefly luciferase gene: structure and expression in mammalian cells.

1987 • 3,088 citations

Complete nucleotide sequence of the AIDS virus, HTLV-III

1985 • 2,236 citations

Fluorographic detection of radioactivity in polyacrylamide gols with the water-soluble fluor, sodium salicylate

1979 • 1,976 citations

Number and evolutionary conservation of α- and β-tubulin and cytoplasmic β- and γ-actin genes using specific cloned cDNA probes

1980 • 1,884 citations

Fundamental techniques in virology.

1969 • 1,768 citations

The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA

1989 • 1,280 citations

Functional dissection of the HIV-1 Rev trans-activator—Derivation of a trans-dominant repressor of Rev function

1989 • 742 citations

HTLV-III expression and production involve complex regulation at the levels of splicing and translation of viral RNA

1986 • 673 citations

A second post-transcriptional trans-activator gene required for HTLV-III replication

1986 • 639 citations

rev protein of human immunodeficiency virus type 1 affects the stability and transport of the viral mRNA.

1989 • 634 citations

Regulation by HIV Rev depends upon recognition of splice sites

1989 • 517 citations

HIV-1 structural gene expression requires binding of the rev trans-activator to its RNA target sequence

1990 • 457 citations

Cloning and functional analysis of multiply spliced mRNA species of human immunodeficiency virus type 1

1990 • 430 citations

The rev gene product of the human immunodeficiency virus affects envelope-specific RNA localization

1989 • 400 citations

Sequence-specific RNA binding by the HIV-1 Rev protein

1989 • 384 citations

Evolution of the Functional Human β-Actin Gene and Its Multi-Pseudogene Family: Conservation of Noncoding Regions and Chromosomal Dispersion of Pseudogenes

1985 • 378 citations

Specific binding of HIV-1 recombinant Rev protein to the Rev-responsive element in vitro

1989 • 377 citations

Regulation of human immunodeficiency virus env expression by the rev gene product

1989 • 365 citations

The rev (trs/art) protein of human immunodeficiency virus type 1 affects viral mRNA and protein expression via a cis-acting sequence in the env region

1989 • 359 citations

Intragenic cis-acting art gene-responsive sequences of the human immunodeficiency virus.

1988 • 355 citations

HIV-1 regulator of virion expression (Rev) protein binds to an RNA stem-loop structure located within the Rev response element region

1990 • 354 citations

Complete Nucleotide Sequences of Functional Clones of the AIDS Virus

1987 • 348 citations

Iron regulation of transferrin receptor mRNA levels requires iron-responsive elements and a rapid turnover determinant in the 3′ untranslated region of the mRNA.

1989 • 334 citations

Cis-Trans Models for Post-Transcriptional Gene Regulation

1989 • 322 citations

A molecular clone of HTLV-III with biological activity

1985 • 320 citations

Variation among human 28S ribosomal RNA genes.

1985 • 294 citations

Distinct RNA sequences in the gag region of human immunodeficiency virus type 1 decrease RNA stability and inhibit expression in the absence of Rev protein

1992 • 276 citations

Env and Vpu proteins of human immunodeficiency virus type 1 are produced from multiple bicistronic mRNAs

1990 • 250 citations

Transcriptional (p40x) and post-transcriptional (p27x-III) regulators are required for the expression and replication of human T-cell leukemia virus type I genes.

1987 • 245 citations

Rev is necessary for translation but not cytoplasmic accumulation of HIV-1 vif, vpr, and env/vpu 2 RNAs.

1991 • 232 citations

Functional replacement of the HIV-1 rev protein by the HTLV-1 rex protein

1988 • 216 citations

Interaction of the human immunodeficiency virus type 1 Rev protein with a structured region in env mRNA is dependent on multimer formation mediated through a basic stretch of amino acids.

1990 • 205 citations

Comparative analysis of the HTLV-I Rex and HIV-1 Rev trans-regulatory proteins and their RNA response elements.

1989 • 188 citations

Secondary Structure is the Major Determinant for Interaction of HIV rev Protein with RNA

1990 • 188 citations

p27x-III and p21x-III, proteins encoded by the pX sequence of human T-cell leukemia virus type I.

1985 • 166 citations

Specific interaction of the human immunodeficiency virus Rev protein with a structured region in the env mRNA.

1990 • 166 citations

Both subunits of rat liver ferritin are regulated at a translational level by iron induction

1986 • 164 citations

Subcellular localization of the human immunodeficiency virus trans-acting art gene product

1988 • 156 citations

Functional Analysis of CAR, the Target Sequence for the Rev Protein of HIV-1

1989 • 152 citations

Two cis-acting elements responsible for posttranscriptional trans-regulation of gene expression of human T-cell leukemia virus type I.

1988 • 150 citations

Feedback regulation of human immunodeficiency virus type 1 expression by the Rev protein

1990 • 130 citations

Identification oftrans-dominant HIV-1 rev protein mutants by direct transfer of bacterially produced proteins into human cells

1990 • 128 citations

Regulation of HIV-1 Gene Expression

1990 • 122 citations

Analysis of rev gene function on human immunodeficiency virus type 1 replication in lymphoid cells by using a quantitative polymerase chain reaction method

1989 • 122 citations

Structure-function analyses of the HTLV-I Rex and HIV-1 Rev RNA response elements: insights into the mechanism of Rex and Rev action.

1990 • 119 citations

Rev activates expression of the human immunodeficiency virus type 1 vif and vpr gene products

1991 • 102 citations

Human immunodeficiency virus rev protein recognizes a target sequence in rev-responsive element RNA within the context of RNA secondary structure

1990 • 102 citations

The second pX product p27^x‐III of HTLV‐1 is required for gag gene expression

1986 • 82 citations

The control of human retrovirus gene expression

1989 • 65 citations

Tat and Rev

1990 • 64 citations

Different sites of interaction for Rev, Tev, and Rex proteins within the Rev-responsive element of human immunodeficiency virus type 1

1990 • 63 citations

Trans-activating rev protein of the human immunodeficiency virus 1 interacts directly and specifically with its target RNA.

1990 • 59 citations

The Rex regulatory protein of human T-cell lymphotropic virus type I binds specifically to its target site within the viral RNA.

1991 • 47 citations

Primary Processing of Mammalian rRNA Involves two Adjacent Cleavages and is not Species Specific

1987 • 41 citations

Isolation of RNA for dot hybridization by heparin-DNase I treatment of whole cell lysate

1987 • 39 citations

The isolation and analysis of polysomes and ribosomal RNA from cells growing in monolayer culture

1977 • 36 citations