Human Cathepsin O2, a Novel Cysteine Protease Highly Expressed in Osteoclastomas and Ovary Molecular Cloning, Sequencing and Tissue Distribution

Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

1986 • 4,785 citations

A new method for predicting signal sequence cleavage sites

1986 • 4,629 citations

Alignment/Phylogeny of the Papain Superfamily of Cysteine Proteases

1995 • 387 citations

The role of proteolytic enzymes in cancer invasion and metastasis

1992 • 372 citations

Molecular Cloning of Human cDNA for Cathepsin K: Novel Cysteine Proteinase Predominantly Expressed in Bone

1995 • 357 citations

Molecular cloning of a possible cysteine proteinase predominantly expressed in osteoclasts.

1994 • 340 citations

Molecular cloning and expression of human alveolar macrophage cathepsin S, an elastinolytic cysteine protease.

1992 • 304 citations

Degradation of collagen in the bone‐resorbing compartment underlying the osteoclast involves both cysteine‐proteinases and matrix metalloproteinases

1992 • 286 citations

Molecular and cellular mechanisms of joint destruction in rheumatoid arthritis: two cellular mechanisms explain joint destruction?

1993 • 272 citations

Inhibitors of the major cysteinyl proteinase (GP57/51) impair host cell invasion and arrest the intracellular development of Trypanosoma cruzi in vitro

1992 • 220 citations

The effects of inhibitors of cysteine-proteinases and collagenase on the resorptive activity of isolated osteoclasts☆

1987 • 176 citations

Molecular cloning of human cathepsin O, a novel endoproteinase and homologue of rabbit OC2

1995 • 167 citations

A comparison of four cathepsins (B, L, N and S) with collagenolytic activity from rabbit spleen

1988 • 158 citations

Inhibition of a Plasmodium vinckei cysteine proteinase cures murine malaria.

1993 • 154 citations

[26] A sensitive and rapid method for recombinant phage screening

1979 • 150 citations

Collagenolytic cysteine proteinases of bone tissue. Cathepsin B, (pro)cathepsin L and a cathepsin L-like 70 kDa proteinase

1991 • 127 citations

Inhibition of bone resorption in culture by inhibitors of thiol proteinases

1980 • 120 citations

Isolation and sequence of a cDNA for human pro-(cathepsin L)

1988 • 98 citations

Effects of the proteinase inhibitors leupeptin and E-64 on osteoclastic bone resorption

1988 • 97 citations

Human cathepsin O. Molecular cloning from a breast carcinoma, production of the active enzyme in Escherichia coli, and expression analysis in human tissues.

1994 • 87 citations

Phylogenetic conservation of cysteine proteinases. Cloning and expression of a cDNA coding for human cathepsin S.

1992 • 77 citations

Cathepsin L Activity Is Increased in Alveolar Macrophages and Bronchoalveolar Lavage Fluid of Smokers

1993 • 61 citations

Peptidyl fluoromethyl ketones as inhibitors of cathepsin B

1992 • 52 citations

Human osteoclastomas contain multiple forms of cathepsin B

1992 • 44 citations

Induction of Emphysema in Hamsters by Intratracheal Instillation of Cathepsin B

1992 • 42 citations

Purification and characterization of a factor catalyzing the conversion of the multiple forms of tyrosine aminotransferase from rat liver.

1980 • 34 citations

Cathepsins J and K: High molecular weight cysteine proteinases from human tissues

1984 • 31 citations

Demonstration of cathepsins B, H and L in xenografts of normal and Duchenne-muscular-dystrophy muscles transplanted into nude mice

1992 • 19 citations

A thermoresistant mutant of ribonuclease T1 having three disulfide bonds

1990 • 16 citations

Relationship between the secretion of cysteine proteinases and their inhibitors and malignant potential

1991 • 13 citations