An ultrastructural evaluation of the effects of cysteine-proteinase inhibitors on osteoclastic resorptive functions

Osteoclastic Bone Resorption by a Polarized Vacuolar Proton Pump

1989 • 864 citations

Cathepsin B1. A lysosomal enzyme that degrades native collagen

1974 • 405 citations

Evidence for the presence of a proton pump of the vacuolar H(+)-ATPase type in the ruffled borders of osteoclasts.

1990 • 390 citations

Further studies on the activation of procollagenase, the latent precursor of bone collagenase. Effects of lysosomal cathepsin B, plasmin and kallikrein, and spontaneous activation

1977 • 389 citations

Human cathepsin B1. Purification and some properties of the enzyme

1973 • 322 citations

Biology and Physiology of the Osteoclast

1992 • 297 citations

Degradation of collagen in the bone‐resorbing compartment underlying the osteoclast involves both cysteine‐proteinases and matrix metalloproteinases

1992 • 286 citations

In vivo and in vitro evidence for the involvement of cysteine proteinases in bone resorption

1984 • 229 citations

The effects of inhibitors of cysteine-proteinases and collagenase on the resorptive activity of isolated osteoclasts☆

1987 • 176 citations

Preparation and characterization of a mouse osteoclast-like multinucleated cell population

1992 • 159 citations

Extracellular presence of the lysosomal proteinase cathepsin B in rheumatoid synovium and its activity at neutral pH

1984 • 153 citations

(Pro)collagenase (matrix metalloproteinase-1) is present in rodent osteoclasts and in the underlying bone-resorbing compartment

1993 • 140 citations

Cathepsin B and L activities in isolated osteoclasts

1991 • 94 citations

New resorption assay with mouse osteoclast-like multinucleated cells formed in vitro

1993 • 93 citations

Immunohistochemical localization of cathepsins B, D and L in the rat osteoclast

1993 • 77 citations

Cystein-proteinase localization in osteoclasts: An immunocytochemical study

1993 • 56 citations

Expression of vacuolar H+-ATPase in osteoclasts and its role in resorption

1994 • 47 citations

Evidence for two pathways for stimulation of collagenolysis in bone

1985 • 38 citations

Recent advances in the ultrastructural assessment of osteoclastic resorptive functions

1996 • 28 citations

Measurement of Howship's Resorption Lacunae by a Scanning Probe Microscope System

1993 • 12 citations