FMRI Measurement of CNS Responses to Naloxone Infusion and Subsequent Mild Noxious Thermal Stimuli in Healthy Volunteers

Descending control of pain

2002 • 2,885 citations

Abstract reward and punishment representations in the human orbitofrontal cortex

2001 • 2,023 citations

Placebo and Opioid Analgesia-- Imaging a Shared Neuronal Network

2002 • 1,466 citations

Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway.

1992 • 1,001 citations

Activation of the left amygdala to a cognitive representation of fear

2001 • 887 citations

Neuropharmacological Dissection of Placebo Analgesia: Expectation-Activated Opioid Systems versus Conditioning-Activated Specific Subsystems

1999 • 863 citations

Reduced fear expression after lesions of the ventral hippocampus

2002 • 852 citations

Mu, delta, and kappa opioid receptor mRNA expression in the rat CNS: An in situ hybridization study

1994 • 840 citations

Regional Mu Opioid Receptor Regulation of Sensory and Affective Dimensions of Pain

2001 • 832 citations

Exacerbation of Pain by Anxiety Is Associated with Activity in a Hippocampal Network

2001 • 803 citations

Reward Circuitry Activation by Noxious Thermal Stimuli

2001 • 490 citations

Role of endogenous opioid system in the regulation of the stress response

2001 • 399 citations

Recent advances in molecular recognition and signal transduction of active peptides: Receptors for opioid peptides

1995 • 386 citations

Noradrenaline systems in the hypothalamus, amygdala and locus coeruleus are involved in the provocation of anxiety: basic studies

2000 • 365 citations

Human brain activation under controlled thermal stimulation and habituation to noxious heat: An fMRI study

1999 • 331 citations

Effects of morphine and naloxone on separation distress and approach attachment: Evidence for opiate mediation of social affect

1978 • 321 citations

Learning about pain: The neural substrate of the prediction error for aversive events

2000 • 242 citations

Partial antagonism of placebo analgesia by naloxone

1983 • 225 citations

Involvement of basal ganglia and orbitofrontal cortex in goal-directed behavior

2000 • 215 citations

Expression of Mu opioid receptor mRNA in rat brain: An in situ hybridization study at the single cell level

1994 • 213 citations

Combining fMRI with a Pharmacokinetic Model to Determine Which Brain Areas Activated by Painful Stimulation Are Specifically Modulated by Remifentanil

2002 • 193 citations

Diffuse noxious inhibitory controls in man: Involvement of an opioidergic link

1990 • 186 citations

Endorphins: Naloxone Fails to Alter Experimental Pain or Mood in Humans

1978 • 184 citations

Mapping of opioid receptors using antisense oligodeoxynucleotides: correlating their molecular biology and pharmacology

1995 • 170 citations

Opposite motivational effects of endogenous opioids in brain and periphery

1985 • 166 citations

Long‐lasting increased pain sensitivity in rat following exposure to heroin for the first time

1998 • 162 citations

Regional Brain Activity Changes Associated with Fentanyl Analgesia Elucidated by Positron Emission Tomography

1997 • 159 citations

Effects of naloxone on experimentally induced ischemic pain and on mood in human subjects.

1977 • 152 citations

A psychophysical analysis of experiential factors that selectively influence the affective dimension of pain

1980 • 142 citations

Human Brain Activity Response to Fentanyl Imaged by Positron Emission Tomography

1996 • 141 citations

Suppression of the morphine‐induced rewarding effect in the rat with neuropathic pain: implication of the reduction in µ‐opioid receptor functions in the ventral tegmental area

2002 • 139 citations

Opioid blockade and social comfort in chicks

1980 • 135 citations

Pain activation of human supraspinal opioid pathways as demonstrated by [11C]-carfentanil and positron emission tomography (PET)

2002 • 132 citations

Endorphins and mood changes in long-distance running

1982 • 128 citations

Regional Brain Activity Changes Associated with Fentanyl Analgesia Elucidated by Positron Emission Tomography

1997 • 115 citations

Naloxone attenuation of the effect of cocaine on rewarding brain stimulation

1987 • 107 citations

Topographical organization of projections from the entorhinal cortex to the striatum of the rat

1997 • 103 citations

Analgesia to pain stimuli in schizophrenics and its reversal by naltrexone

1979 • 102 citations

Changes in reward‐induced brain activation in opiate addicts

2001 • 99 citations

Acute opioid physical dependence in postaddict humans: naloxone dose effects after brief morphine exposure.

1989 • 99 citations

Neuroanatomical and psychopharmacological evidence for interaction between opioid and GABAergic neural pathways in the modulation of fear and defense elicited by electrical and chemical stimulation of the deep layers of the superior colliculus and dorsal periaqueductal gray matter

2002 • 98 citations

Early exposure to chronic variable stress facilitates the occurrence of anhedonia and enhanced emotional reactions to novel stressors: reversal by naltrexone pretreatment

2000 • 95 citations

Nalmefene Causes Greater Hypothalamic‐Pituitary‐Adrenal Axis Activation than Naloxone in Normal Volunteers: Implications for the Treatment of Alcoholism

1998 • 93 citations

Endogenous opioid regulation of stress-induced oxytocin release within the hypothalamic paraventricular nucleus is reversed in late pregnancy: a microdialysis study

2002 • 72 citations

Interactions between sympathetic vasoconstrictor outflow and C nociceptor-induced antidromic vasodilatation

1993 • 62 citations

Somatosensory Processing in the Human Inferior Prefrontal Cortex

2002 • 57 citations

Hyperalgesia During Opioid Abstinence: Mediation by Glutamate and Substance P

2002 • 52 citations

Effects of naloxone on diurnal rhythms in mood and endocrine function: a dose-response study in man

1994 • 50 citations

Pain enhances naloxone-induced hyperalgesia in humans as assessed by somatosensory evoked potentials

1983 • 49 citations

Endogenous Opioids in Dopaminergic Cell Body Regions Modulate Amphetamine-Induced Increases in Extracellular Dopamine Levels in the Terminal Regions

2002 • 45 citations

Involvement of the mesolimbic dopamine system in mediating the aversive effects of opioid antagonists in the rat

1995 • 45 citations

Endogenous opiates and behavior: 2002

2003 • 45 citations

Naloxone does not alter the perception of pain induced by electrical and thermal stimulation of the skin in healthy humans

1988 • 44 citations

Endorphins in psychiatry.

1984 • 44 citations

Functional Magnetic Resonance Neuroimaging of Drug Dependence: Naloxone-Precipitated Morphine Withdrawal

2002 • 41 citations

Naltrexone affects cocaine self-administration in naı̈ve rats through the ventral tegmental area rather than dopaminergic target regions

1999 • 40 citations

Opioid receptor modulation of feeding-evoked dopamine release in the rat nucleus accumbens

1998 • 39 citations

Effect of 12-hour infusion of naloxone on mood and cognition in normal male volunteers

1992 • 38 citations

Naloxone-induced changes in tachykinin NK3 receptor modulation of experimental anxiety in mice

1998 • 38 citations

Motivational effects of opioids: Evidence on the role of endorphins in mediating reward or aversion

1985 • 37 citations

Skin blood flow abnormalities in a rat model of neuropathic pain: Result of decreased sympathetic vasoconstrictor outflow?

1997 • 27 citations

The acquisition and maintenance of voluntary ethanol drinking in the rat: effects of dopaminergic lesions and naloxone

2002 • 26 citations

Human Brain Activity Response to Fentanyl Imaged by Positron Emission Tomography

1996 • 26 citations

The Physiology of Opiate Hedonic Effects and the Role of Opioids in Motivated Behavior

1984 • 22 citations

Opioids modulate stress-induced proenkephalin gene expression in the hypothalamus of transgenic mice: a model of endogenous opioid gene regulation by exogenous opioids

1994 • 22 citations

Performance and physiological measures in abuse liability evaluation

1991 • 21 citations

A possible role of opioid substances in depression.

1982 • 20 citations

Effects of naloxene on the subjective and psychomotor effects of nitrous oxide in humans

1994 • 20 citations

Pain modulation and the action of analgesic medications

1994 • 19 citations

Bilateral sympathetic skin response following nociceptive stimulation: study in healthy individuals.

1994 • 19 citations

Naloxone blocks ‘anxiolytic’ effects of neuropeptide Y

2001 • 17 citations

Naloxone's effect on cognitive functioning in drug-free and diazepam-treated normal humans

1985 • 17 citations

Comparison of time course of neuromuscular blockade in young children following rocuronium and atracurium

1998 • 16 citations

Antagonists of benzodiazepines.

1983 • 15 citations

Increases in cerebral blood flow in rat hippocampus after medial septal injection of naloxone.

1992 • 15 citations

Comparison of time course of neuromuscular blockade in young children following rocuronium and atracurium

1998 • 11 citations

Endorphins and mood changes in long-distance running

1982 • 11 citations

Action of Opioid Drugs on the Brain-Reward System

1995 • 9 citations

[Effects of neuropeptide Y].

1993 • 9 citations

[Reversal by naloxone of the effects of morphine on the unanesthetized dog].

1976 • 8 citations

Changes in sensitivity of neurons to synaptic actions during imprinting

1995 • 7 citations

INFLUENCE OF DRUGS ON EVOKED POTENTIALS IN THE CAT CEREBELLUM: II. EFFECTS OF MORPHINE HYDROCHLORIDE (1)

1983 • 6 citations

Influence of drugs on evoked potentials in the cat cerebellum: II. Effects of morphine hydrochloride (1).

1983 • 5 citations