Perforin-dependent NK cell cytotoxicity is sufficient for anti-metastatic effect of IL-12

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

1994 • 1,772 citations

NK CELL RECEPTORS

1998 • 1,666 citations

Requirement for V _α 14 NKT Cells in IL-12-Mediated Rejection of Tumors

1997 • 1,226 citations

Antitumor and antimetastatic activity of interleukin 12 against murine tumors.

1993 • 1,206 citations

Recombinant IL-12 administration induces tumor regression in association with IFN-gamma production.

1994 • 796 citations

Decreased tumor surveillance in perforin-deficient mice.

1996 • 487 citations

Fas-mediated cytotoxicity by freshly isolated natural killer cells.

1995 • 372 citations

The CXC Chemokines IP-10 and Mig Are Necessary for IL-12-Mediated Regression of the Mouse RENCA Tumor

1998 • 295 citations

Interleukin-12

1994 • 285 citations

Spontaneous Development of Plasmacytoid Tumors in Mice with Defective Fas–Fas Ligand Interactions

1998 • 181 citations

Critical role of NK1+ T cells in IL-12-induced immune responses in vivo.

1998 • 179 citations

Liver NK1.1+ CD4+ alpha beta T cells activated by IL-12 as a major effector in inhibition of experimental tumor metastasis.

1996 • 175 citations

Cytotoxicity of fresh NK1.1+ T cell receptor alpha/beta+ thymocytes against a CD4+8+ thymocyte population associated with intact Fas antigen expression on the target.

1994 • 144 citations

Cutting Edge: Critical Role of NK1+ T Cells in IL-12-Induced Immune Responses In Vivo

1998 • 136 citations

Involvement of NK1+ T cells and their IFN-gamma production in the generalized Shwartzman reaction.

1998 • 126 citations

Involvement of NK1+ T Cells and Their IFN-γ Production in the Generalized Shwartzman Reaction

1998 • 105 citations

Molecular mechanisms underlying IFN-_γ-mediated tumor growth inhibition induced during tumor growth inhibition induced during tumor immunotherapy with rIL-12

1996 • 92 citations

Interferon-γ and interleukin-4 regulate T cell interleukin-12 responsiveness through the differential modulation of high-affinity interleukin-12 receptor expression

1997 • 82 citations

Regulation of human natural killer cell activity by interferon-gamma: lack of a role in interleukin 2-mediated augmentation.

1986 • 57 citations

Antimetastatic effect of NK1⁺ T cells on experimental haematogenous tumour metastases in the liver and lungs of mice

1997 • 56 citations

Interleukin‐12 induces cytotoxic NK1⁺αβ T cells in the lungs of euthymic and athymic mice

1996 • 37 citations