Platelet activating factor produced in vitro by Kaposi's sarcoma cells induces and sustains in vivo angiogenesis.

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Interleukin-8 as a Macrophage-Derived Mediator of Angiogenesis

1992 • 2,130 citations

High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis

1993 • 1,961 citations

LEUKOCYTE LOCOMOTION AND CHEMOTAXIS

1973 • 1,709 citations

Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth.

1992 • 1,345 citations

Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation

1992 • 1,103 citations

The origin and function of tumor-associated macrophages

1992 • 1,081 citations

Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor.

1991 • 999 citations

Molecular cloning of gene sequences regulated by platelet-derived growth factor

1983 • 989 citations

Platelet-activating factor.

1990 • 904 citations

Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumors.

1992 • 900 citations

Tat protein of HIV-1 stimulates growth of cells derived from Kaposi's sarcoma lesions of AIDS patients

1990 • 899 citations

A simple, quantitative method for assessing angiogenesis and antiangiogenic agents using reconstituted basement membrane, heparin, and fibroblast growth factor.

1992 • 807 citations

Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium.

1993 • 764 citations

Tumor necrosis factor type alpha, a potent inhibitor of endothelial cell growth in vitro, is angiogenic in vivo.

1987 • 718 citations

Cytokine therapeutics: lessons from interferonalpha.

1994 • 703 citations

Coexpression of GMP-140 and PAF by endothelium stimulated by histamine or thrombin: a juxtacrine system for adhesion and activation of neutrophils.

1991 • 600 citations

Cloning by functional expression of platelet-activating factor receptor from guinea-pig lung

1991 • 594 citations

The HIV tat gene induces dermal lesions resembling Kaposi's sarcoma in transgenic mice

1988 • 532 citations

An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes a growth factor that is a member of the FGF family

1987 • 525 citations

AIDS Kaposi sarcoma-derived cells produce and respond to interleukin 6.

1990 • 500 citations

AIDS-Kaposi's Sarcoma-Derived Cells Express Cytokines with Autocrine and Paracrine Growth Effects

1989 • 476 citations

Cloning and expression of JE, a gene inducible by platelet-derived growth factor and whose product has cytokine-like properties.

1988 • 444 citations

The release of platelet-activating factor from human endothelial cells in culture.

1983 • 436 citations

Immunoreactive fibroblast growth factor in cells of peritoneal exudate suggests its identity with macrophage-derived growth factor

1985 • 372 citations

Tumor necrosis factor/cachectin stimulates peritoneal macrophages, polymorphonuclear neutrophils, and vascular endothelial cells to synthesize and release platelet-activating factor.

1987 • 364 citations

Kaposi's Sarcoma Cells: Long-Term Culture with Growth Factor from Retrovirus-Infected CD4 ⁺ T Cells

1988 • 337 citations

Angiogenic Properties of Kaposi's Sarcoma-Derived Cells After Long-Term Culture in Vitro

1988 • 335 citations

Kaposi's sarcoma

1993 • 316 citations

Cloning and characterization of cDNAs for murine macrophage inflammatory protein 2 and its human homologues.

1990 • 298 citations

Isolation of cDNAs encoding four mouse FGF family members and characterization of their expression patterns during embryogenesis

1990 • 266 citations

The Natural History of Kaposi's Sarcoma in the Acquired Immunodeficiency Syndrome

1985 • 251 citations

Oncostatin M as a Potent Mitogen for AIDS-Kaposi's Sarcoma-Derived Cells

1992 • 251 citations

Sequence, topography and protein coding potential of mouse int-2: a putative oncogene activated by mouse mammary tumour virus.

1986 • 234 citations

Identification of a Major Growth Factor for AIDS-Kaposi's Sarcoma Cells as Oncostatin M

1992 • 227 citations

Synthesis and release of platelet-activating factor by human vascular endothelial cells treated with tumor necrosis factor or interleukin 1 alpha.

1988 • 221 citations

Neutrophil migration across monolayers of cytokine-prestimulated endothelial cells: a role for platelet-activating factor and IL-8.

1992 • 213 citations

Risk of Kaposi's sarcoma and sexual practices associated with faecal contact in homosexual or bisexual men with AIDS

1992 • 206 citations

Effects of cytokines from activated immune cells on vascular cell growth and HIV-1 gene expression. Implications for AIDS-Kaposi's sarcoma pathogenesis.

1992 • 203 citations

Characterization of a human cDNA that encodes a functional receptor for platelet activating factor

1991 • 179 citations

Human endothelial cells are target for platelet-activating factor. I. Platelet-activating factor induces changes in cytoskeleton structures.

1987 • 178 citations

AIDS-associated kaposi's sarcoma cells in culture express vascular endothelial growth factor

1992 • 164 citations

Cytokines and Growth Factors in the Pathogenesis of AIDS‐Associated Kaposi's Sarcoma

1992 • 155 citations

Angiogenic potential in vivo by Kaposiʼs sarcoma cell-free supernatants and HIV-1 tat product: inhibition of KS-like lesions by tissue inhibitor of metalloproteinase-2

1994 • 154 citations

Platelet-activating factor and retinoic acid synergistically activate the inducible prostaglandin synthase gene.

1994 • 152 citations

The expression of endothelial cell surface antigens by AIDS-associated Kaposi's sarcoma. Evidence for a vascular endothelial cell origin.

1986 • 149 citations

Tumor necrosis factor alpha-induced angiogenesis depends on in situ platelet-activating factor biosynthesis.

1994 • 149 citations

Early lesions of Kaposi's sarcoma in homosexual men. An ultrastructural comparison with other vascular proliferations in skin.

1983 • 133 citations

Expression of platelet-derived growth factor and its receptor in AIDS-related Kaposi sarcoma in vivo suggests paracrine and autocrine mechanisms of tumor maintenance.

1992 • 130 citations

Platelet-activating factor and related lipid mediators

1988 • 130 citations

HPV-16-related DNA sequences in Kaposi's sarcoma

1992 • 128 citations

Pharmacologic activity of bepafant (WEB 2170), a new and selective hetrazepinoic antagonist of platelet activating factor.

1990 • 114 citations

Expression of adhesion molecules, platelet-activating factor, and chemokines by Kaposi's sarcoma cells.

1994 • 104 citations

Stimulation of Platelet-activating Factor Synthesis by a Nonmetabolizable Bioactive Analog of Platelet-activating Factor and Influence of Arachidonic Acid Metabolites

1989 • 98 citations

Role of scatter factor in the pathogenesis of AIDS-related Kaposi sarcoma.

1994 • 97 citations

Molecular organization of the HLA-SB region of the human major histocompatibility complex and evidence for two SB beta-chain genes.

1984 • 91 citations

Treatment of Advanced Kaposiʼs Sarcoma Using a Combination of Bleomycin and Vincristine

1990 • 90 citations

Kaposi's Sarcoma in Uganda: Geographic and Ethnic Distribution

1972 • 88 citations

Inhibition of Development of Kaposi's Sarcoma-Related Lesions by a Bacterial Cell Wall Complex

1992 • 88 citations

Human endothelial cells are targets for platelet-activating factor (PAF). Activation of alpha and beta protein kinase C isozymes in endothelial cells stimulated by PAF.

1994 • 81 citations

Culture and properties of cells derived from Kaposi sarcoma.

1991 • 80 citations

PAF molecular heterogeneity: pathobiological implications.

1993 • 78 citations

AIDS-associated Kaposi's sarcoma-derived cells in long-term culture express and synthesize smooth muscle alpha-actin.

1991 • 76 citations

Characterization of the mouse cDNA and gene coding for a hepatocyte growth factor-like protein: expression during development

1991 • 74 citations

Fibroblast growth factor gene expression in AIDS-Kaposi's sarcoma detected by in situ hybridization.

1991 • 71 citations

Structure, chromosome mapping and expression of the murine Fgf-6 gene.

1990 • 67 citations

Myogenic cells in Kaposi's sarcoma: An ultrastructural study

1978 • 60 citations

Cells derived from sporadic and aids‐related Kaposi's sarcoma reveal identical cytochemical and molecular properties in vitro

1989 • 57 citations

Supernatants of acquired immunodeficiency syndrome-related Kaposi's sarcoma cells induce endothelial cell chemotaxis and invasiveness.

1991 • 54 citations

Intravenous recombinant tumor necrosis factor in the treatment of AIDS-related Kaposi's sarcoma.

1989 • 52 citations

A Review of Kaposi's Sarcoma

1989 • 47 citations

Streptokinase induces intravascular release of platelet-activating factor in patients with acute myocardial infarction and stimulates its synthesis by cultured human endothelial cells.

1993 • 44 citations

Expression of int-2 oncogene in Kaposi's sarcoma lesions.

1993 • 43 citations

Platelet activating factors alters calcium homeostasis in cultured vascular endothelial cells

1986 • 38 citations

Identification and functional characterization of platelet-activating factor receptors in human leukocyte populations using polyclonal anti-peptide antibody.

1993 • 38 citations

Platelet-activating factor-induced homologous and heterologous desensitization in cultured vascular smooth muscle cells.

1988 • 38 citations

Expression of fibroblast growth factors and their receptors in acquired immunodeficiency syndrome—associated Kaposi sarcoma tissue and derived cells

1993 • 37 citations

Spindle cell ploidy and proliferation in endemic and epidemic African Kaposi's sarcoma

1992 • 37 citations

Invasive activity and chemotactic response to growth factors by Kaposi's sarcoma cells

1988 • 33 citations

Activation of NF- B and Immunoglobulin Expression in Response to Platelet-Activating Factor in a Human B Cell Line

1994 • 28 citations

PLATELET ACTIVATING FACTOR

1990 • 24 citations

Propagation and properties of Kaposiʼs sarcoma-derived cell lines obtained from patients with AIDS: similarity of cultured cells to smooth muscle cells

1991 • 24 citations

Immune Regulation by Platelet-Activating Factor: II. Mediation of Suppression by Cytokine-Stimulated Endothelial Cells In Vitro

1991 • 23 citations

Supernatants of acquired immunodeficiency syndrome-related Kaposi's sarcoma cells induce endothelial cell chemotaxis and invasiveness

1991 • 22 citations

Kaposiʼs sarcoma unrelated to the acquired immunodeficiency syndrome

1991 • 18 citations

Cytokine regulation by platelet-activating factor in a human B cell line.

1994 • 16 citations

The role of opportunistic viruses in Kaposi's sarcoma (KS) evolution.

1989 • 15 citations

Differentiation-dependent modulation of TNF production by PAF in human HL-60 myeloid leukemia cells

1992 • 14 citations

The effect of the selective PAF antagonist WEB 2170 on PAF and antigen induced airway hyperresponsiveness and eosinophil infiltration.

1991 • 13 citations

CD2 triggering stimulates the formation of platelet-activating factor-acether from alkyl-arachidonoyl-glycerophosphocholine in a human CD4+ T lymphocyte clone.

1992 • 11 citations

Hetrazepine PAF antagonists.

1992 • 8 citations

AIDS-associated Kaposi's sarcoma.

1990 • 5 citations