Streptokinase induces intravascular release of platelet-activating factor in patients with acute myocardial infarction and stimulates its synthesis by cultured human endothelial cells.

Thrombolysis in Myocardial Infarction (TIMI) Trial, Phase I: A comparison between intravenous tissue plasminogen activator and intravenous streptokinase. Clinical findings through hospital discharge.

1987 • 2,245 citations

Platelet-activating factor.

1990 • 904 citations

RANDOMISED TRIAL OF INTRAVENOUS RECOMBINANT TISSUE-TYPE PLASMINOGEN ACTIVATOR VERSUS INTRAVENOUS STREPTOKINASE IN ACUTE MYOCARDIAL INFARCTION

1985 • 756 citations

Basic and clinical aspects of fibrinolysis and thrombolysis

1991 • 653 citations

Myocardial reperfusion, limitation of infarct size, reduction of left ventricular dysfunction, and improved survival. Should the paradigm be expanded?

1989 • 560 citations

Reperfusion injury and its pharmacologic modification.

1989 • 509 citations

Platelets and Thrombolytic Therapy

1990 • 485 citations

Physicochemical and Functional Identity of Rabbit Platelet-Activating Factor (PAF) Released in Vivo during IgE Anaphylaxis with PAF Released in Vitro from IgE Sensitized Basophils

1979 • 454 citations

Human endothelial cells in culture produce platelet-activating factor (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) when stimulated with thrombin.

1984 • 442 citations

Marked platelet activation in vivo after intravenous streptokinase in patients with acute myocardial infarction.

1988 • 441 citations

The release of platelet-activating factor from human endothelial cells in culture.

1983 • 436 citations

Hydrogen peroxide stimulates the synthesis of platelet-activating factor by endothelium and induces endothelial cell-dependent neutrophil adhesion.

1988 • 421 citations

Tumor necrosis factor/cachectin stimulates peritoneal macrophages, polymorphonuclear neutrophils, and vascular endothelial cells to synthesize and release platelet-activating factor.

1987 • 364 citations

Chemical and biochemical aspects of platelet activating factor: A novel class of acetylated ether‐linked choline‐phospholipids

1985 • 359 citations

A rapid enzymatic method for assay of fibrinogen fibrin polymerization time (FPT test)

1963 • 261 citations

Free Radicals and Their Involvement During Long-Term Myocardial Ischemia and Reperfusion

1990 • 259 citations

Nitroglycerin Stimulates Synthesis of Prostacyclin by Cultured Human Endothelial Cells

1981 • 252 citations

Acute circulatory collapse caused by platelet-activating factor (PAF-acether) in dogs

1983 • 243 citations

Thrombolytic therapy with tissue plasminogen activator or streptokinase induces transient thrombin activity

1988 • 239 citations

Paradoxic elevation of fibrinopeptide A after streptokinase: Evidence for continued thrombosis despite intense fibrinolysis

1987 • 213 citations

Acetyl glyceryl ether phosphorylcholine (AGEPC). A putative mediator of cardiac anaphylaxis in the guinea pig.

1984 • 203 citations

Platelet and vascular function during coronary thrombolysis with tissue-type plasminogen activator.

1989 • 130 citations

Platelet protein phosphorylation, elevation of cytosolic calcium, and inositol phospholipid breakdown in platelet activation induced by plasmin.

1986 • 124 citations

Respiratory and circulatory alterations induced by acetyl glyceryl ether phosphorylcholine, a mediator of IgE anaphylaxis in the rabbit.

1980 • 123 citations

Pharmacologic activity of bepafant (WEB 2170), a new and selective hetrazepinoic antagonist of platelet activating factor.

1990 • 114 citations

Production of platelet-activating factor by human vascular endothelial cells: evidence for a requirement for specific agonists and modulation by prostacyclin.

1985 • 113 citations

The actions of Paf‐acether (platelet‐activating factor) on guinea‐pig isolated heart preparations

1983 • 111 citations

Effects of acetyl glyceryl ether of phosphorylcholine (platelet activating factor) on ventricular preload, afterload, and contractility in dogs.

1984 • 105 citations

Synthesis and release of platelet-activating factor is inhibited by plasma alpha 1-proteinase inhibitor or alpha 1-antichymotrypsin and is stimulated by proteinases.

1988 • 104 citations

The role of platelet-activating factor in inflammation

1990 • 90 citations

Molecular cloning and characterization of the platelet-activating factor receptor gene expressed in the human heart

1992 • 89 citations

Role of platelet activating factor in propagation of cardiac damage during myocardial ischemia.

1988 • 85 citations

Release of Platelet-Activating Factor in Systemic Lupus erythematosus

1990 • 81 citations

Effect of platelet-activating factor on coronary circulation of the domestic pig

1984 • 77 citations

The effects of organic nitrates on prostacyclin biosynthesis and platelet function in humans.

1984 • 66 citations

High-dose, brief-duration intravenous infusion of streptokinase in acute myocardial infarction: Description of effects in the circulation

1986 • 55 citations

Negative inotropic effect of platelet-activating factor on human myocardium: a pharmacological study.

1987 • 54 citations

Effect of platelet activating factor on guinea-pig papillary muscle

1984 • 53 citations

Effect of Platelet-Activating Factor (PAF) on Human Cardiac Muscle

1986 • 48 citations

Mechanisms of hypotension produced by platelet-activating factor

1989 • 45 citations

Platelet-activating factor and the release of a platelet-derived coronary artery vasodilator substance in the canine.

1986 • 45 citations

Role of platelet-activating factor in the reperfusion injury of rabbit ischemic heart.

1990 • 37 citations

Basic and clinical aspects of fibrinolysis and thrombolysis

1991 • 36 citations

Evidence for a role of platelet activating factor in the pathogenesis of irreversible but not reversible myocardial injury after reperfusion in dogs

1990 • 35 citations

Free Radicals And Their Involvement During Long-Term Myocardial Ischemia And Reperfusion

1990 • 35 citations

Mechanisms of the cardioprotective actions of WEB-2170, bepafant, a platelet activating factor antagonist, in myocardial ischemia and reperfusion.

1992 • 34 citations

In Vitro and In Vivo Pharmacological Profiles of the PAF Receptor Antagonist SRI 63-675

1987 • 34 citations

Negative inotropic effect of platelet-activating factor: association with a decrease in intracellular sodium activity.

1988 • 33 citations

Thrombolytic Treatment of Acute Myocardial Infarction

1985 • 32 citations

Molecular and cellular actions of platelet-activating factor in rat heart cells.

1991 • 31 citations

Enhanced glomerular thromboxane A2 mediates some pathophysiologic effect of platelet-activating factor in rabbit nephrotoxic nephritis: evidence from biochemical measurements and inhibitor trials.

1989 • 30 citations

PLATELET ACTIVATING FACTOR

1990 • 24 citations

Role of platelet-activating factor in hypotension and platelet activation induced by infusion of thrombolytic agents in rabbits.

1993 • 22 citations

Inhibition of vascular endothelial cell prostacyclin synthesis by plasmin

1989 • 20 citations

Inhibition of vascular endothelial cell prostacyclin synthesis by plasmin

1989 • 17 citations

Inhibition of cyclic flow variations and reocclusion after thrombolysis in dogs by a novel antagonist of platelet-activating factor

1991 • 17 citations

Platelet-activating Factor in Bronchoalveolar Lavage from Patients with Sarcoidosis

1992 • 16 citations

Thrombolytic treatment for acute myocardial infarction

1990 • 15 citations

Thrombolytic therapy with tissue plasminogen activator or streptokinase induces transient thrombin activity

1988 • 13 citations

Platelet activating factor is produced during infectious peritonitis in CAPD patients

1989 • 11 citations

Effect of streptokinase on prostacyclin synthesis and phospholipase activity in cultured pulmonary artery endothelial cells

1990 • 2 citations

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