Nitrogen regulation in Saccharomyces cerevisiae

TOR, a Central Controller of Cell Growth

2000 • 1,919 citations

The molecular biology of the yeast saccharomyces: Metabolism and gene expression

1983 • 1,118 citations

The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors

1999 • 918 citations

The Molecular Biology of the Yeast Saccharomyces (Metabolism and Gene Expression)

1985 • 712 citations

The TOR signaling cascade regulates gene expression in response to nutrients

1999 • 593 citations

Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins

1999 • 526 citations

A Family of Ammonium Transporters in Saccharomyces cerevisiae†

1997 • 523 citations

Multiplicity of the amino acid permeases in Saccharomyces cerevisiae

1967 • 403 citations

The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene

1993 • 379 citations

Asymmetric Accumulation of Ash1p in Postanaphase Nuclei Depends on a Myosin and Restricts Yeast Mating-Type Switching to Mother Cells

1996 • 355 citations

Multiplicity of the Amino Acid Permeases in Saccharomyces cerevisiae IV. Evidence for a General Amino Acid Permease

1970 • 334 citations

NPI1, an essential yeast gene involved in induced degradation of Gap1 and Fur4 permeases, encodes the Rsp5 ubiquitin—protein ligase

1995 • 331 citations

Nitrogen Catabolite Repression in Yeasts and Filamentous Fungi

1985 • 315 citations

The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease

1998 • 308 citations

GAP1, the general amino acid permease gene of Saccharomyces cerevisiae

1990 • 296 citations

Starvation Induces Vacuolar Targeting and Degradation of the Tryptophan Permease in Yeast

1999 • 289 citations

Identification of an Asymmetrically Localized Determinant, Ash1p, Required for Lineage-Specific Transcription of the Yeast HO Gene

1996 • 278 citations

A Transcriptional Switch in the Expression of Yeast Tricarboxylic Acid Cycle Genes in Response to a Reduction or Loss of Respiratory Function

1999 • 277 citations

The URE2 gene product of Saccharomyces cerevisiae plays an important role in the cellular response to the nitrogen source and has homology to glutathione s-transferases.

1991 • 276 citations

Components of a Ubiquitin Ligase Complex Specify Polyubiquitination and Intracellular Trafficking of the General Amino Acid Permease

2001 • 270 citations

The role of ammonia metabolism in nitrogen catabolite repression inSaccharomyces cerevisiae

2000 • 255 citations

Classification of all putative permeases and other membrane plurispanners of the major facilitator superfamily encoded by the complete genome of Saccharomyces cerevisiae

2006 • 249 citations

An overview of membrane transport proteins in Saccharomyces cerevisiae

1995 • 241 citations

Nitrogen Catabolite Repression in Saccharomyces cerevisiae

1999 • 233 citations

Tripartite Regulation of Gln3p by TOR, Ure2p, and Phosphatases

2000 • 228 citations

Mechanism of Metabolic Control

2000 • 220 citations

Nitrogen-regulated Ubiquitination of the Gap1 Permease ofSaccharomyces cerevisiae

1998 • 211 citations

Substrate specificity and gene expression of the amino-acid permeases in Saccharomyces cerevisiae

1999 • 210 citations

Nitrogen Metabolism in Saccharomyces cerevisiae

1982 • 203 citations

Sequence and expression of GLN3, a positive nitrogen regulatory gene of Saccharomyces cerevisiae encoding a protein with a putative zinc finger DNA-binding domain.

1991 • 195 citations

Physiological Regulation of Membrane Protein Sorting Late in the Secretory Pathway of Saccharomyces cerevisiae

1997 • 191 citations

Regulation of nitrogen assimilation in Saccharomyces cerevisiae: roles of the URE2 and GLN3 genes

1988 • 186 citations

7 General and Pathway-specific Regulatory Mechanisms Controlling the Synthesis of Amino Acid Biosynthetic Enzymes in Saccharomyces cerevisiae

1992 • 167 citations

Two FK506 resistance-conferring genes in Saccharomyces cerevisiae, TAT1 and TAT2, encode amino acid permeases mediating tyrosine and tryptophan uptake.

1994 • 164 citations

LST1 Is a SEC24 Homologue Used for Selective Export of the Plasma Membrane ATPase from the Endoplasmic Reticulum

1999 • 163 citations

The Npr1 Kinase Controls Biosynthetic and Endocytic Sorting of the Yeast Gap1 Permease

2001 • 162 citations

Molecular characterization of the CAN1 locus in Saccharomyces cerevisiae. A transmembrane protein without N-terminal hydrophobic signal sequence.

1985 • 161 citations

Transcriptional and posttranslational regulation of the general amino acid permease of Saccharomyces cerevisiae

1995 • 161 citations

Role of NAD-linked glutamate dehydrogenase in nitrogen metabolism in Saccharomyces cerevisiae

1990 • 154 citations

The histidine permease gene (HIP1) of Saccharomyces cerevisiae

1985 • 154 citations

Genetic and Biochemical Analysis of the Yeast Plasma Membrane Ssy1p-Ptr3p-Ssy5p Sensor of Extracellular Amino Acids

2001 • 151 citations

Expression of the DAL80 gene, whose product is homologous to the GATA factors and is a negative regulator of multiple nitrogen catabolic genes in Saccharomyces cerevisiae, is sensitive to nitrogen catabolite repression.

1991 • 150 citations

Control of Amino Acid Permease Sorting in the Late Secretory Pathway of Saccharomyces cerevisiae by SEC13, LST4, LST7 and LST78

1997 • 148 citations

Role of the GATA factors Gln3p and Nil1p of Saccharomyces cerevisiae in the expression of nitrogen-regulated genes.

1995 • 147 citations

NH4+-induced down-regulation of the Saccharomyces cerevisiae Gap1p permease involves its ubiquitination with lysine-63-linked chains

1999 • 144 citations

Regulation of glutamine-repressible gene products by the GLN3 function in Saccharomyces cerevisiae.

1984 • 139 citations

Gat1p, a GATA Family Protein Whose Production Is Sensitive to Nitrogen Catabolite Repression, Participates in Transcriptional Activation of Nitrogen-Catabolic Genes in Saccharomyces cerevisiae

1996 • 138 citations

Multiple Levels of Posttranscriptional Control Lead to Germ Line-Specific Gene Expression in the Zebrafish

2002 • 129 citations

Proline transport in Saccharomyces cerevisiae

1981 • 125 citations

Cross regulation of four GATA factors that control nitrogen catabolic gene expression in Saccharomyces cerevisiae

1997 • 123 citations

Mks1 in Concert with TOR Signaling Negatively Regulates RTG Target Gene Expression in S. cerevisiae

2002 • 116 citations

Ammonia assimilation in Saccharomyces cerevisiae as mediated by the two glutamate dehydrogenases

1974 • 113 citations

Interaction of the GATA factor Gln3p with the nitrogen regulator Ure2p in Saccharomyces cerevisiae

1996 • 109 citations

RTG-dependent Mitochondria-to-Nucleus Signaling Is Regulated by MKS1 and Is Linked to Formation of Yeast Prion [URE3]

2002 • 107 citations

Nucleotide sequence of the Saccharomyces cerevisiae PUT4 proline-permease-encoding gene: similarities between CAN1, HIP1 and PUT4 permeases

1989 • 106 citations

Inactivation‐Reactivation Process and Repression of Permease Formation Regulate Several Ammonia‐Sensitive Permeases in the Yeast Saccharomyces cerevisiae

1983 • 103 citations

Ureidosuccinic Acid Uptake in Yeast and Some Aspects of Its Regulation

1972 • 103 citations

Amino acid transporters of lower eukaryotes: regulation, structure and topogenesis

1995 • 99 citations

TheSaccharomyces cerevisiae NPR1 gene required for the activity of ammonia-sensitive amino acid permeases encodes a protein kinase homologue

1990 • 98 citations

Study of the Positive Control of the General Amino‐Acid Permease and Other Ammonia‐Sensitive Uptake Systems by the Product of the NPR1 Gene in the Yeast Saccharomyces cerevisiae

1983 • 95 citations

Gzf3p, a fourth GATA factor involved in nitrogen‐regulated transcription in Saccharomyces cerevisiae

1997 • 93 citations

Positive selection of general amino acid permease mutants in Saccharomyces cerevisiae

1975 • 91 citations

The GLN3 gene product is required for transcriptional activation of allantoin system gene expression in Saccharomyces cerevisiae

1990 • 84 citations

Identification of sequences responsible for transcriptional activation of the allantoate permease gene in Saccharomyces cerevisiae.

1989 • 79 citations

The Saccharomyces cerevisiae DAL80 repressor protein binds to multiple copies of GATAA-containing sequences (URSGATA)

1993 • 74 citations

Ammonia Regulation of Amino Acid Permeases in Saccharomyces cerevisiae

1983 • 73 citations

Purification and properties of glutamine synthetase from Saccharomyces cerevisiae.

1983 • 73 citations

A C‐terminal di‐leucine motif and nearby sequences are required for NH₄⁺‐induced inactivation and degradation of the general amino acid permease, Gap1p, of Saccharomyces cerevisiae

1997 • 71 citations

Role of the complex upstream region of the GDH2 gene in nitrogen regulation of the NAD-linked glutamate dehydrogenase in Saccharomyces cerevisiae.

1991 • 69 citations

Sequence of the GLN1 gene of Saccharomyces cerevisiae: role of the upstream region in regulation of glutamine synthetase expression

1992 • 66 citations

Isolation of the NPRI gene responsible for the reactivatiion of ammonia‐sensitive amino‐acid permeases in Saccharomyces cerevisiae

1987 • 66 citations

Isolation and Characterization of Mutants that Produce the Allantoin-Degrading Enzymes Constitutively in Saccharomyces cerevisiae

1982 • 65 citations

Recognition of nitrogen-responsive upstream activation sequences of Saccharomyces cerevisiae by the product of the GLN3 gene

1995 • 65 citations

TheSaccharomyces cerevisiae YCC5(YCL025c) Gene Encodes an Amino Acid Permease, Agp1, Which Transports Asparagine and Glutamine

1998 • 63 citations

Nitrogen Catabolite Repression of DAL80Expression Depends on the Relative Levels of Gat1p and Ure2p Production in Saccharomyces cerevisiae

2000 • 63 citations

The UGA4 UASNTR site required for GLN3-dependent transcriptional activation also mediates DAL80-responsive regulation and DAL80 protein binding in Saccharomyces cerevisiae

1994 • 63 citations

Two transcription factors, Gln3p and Nil1p, use the same GATAAG sites to activate the expression of GAP1 of Saccharomyces cerevisiae

1996 • 60 citations

Roles of URE2 and GLN3 in the Proline Utilization Pathway in Saccharomyces cerevisiae

1995 • 60 citations

Ammonia regulation of amino acid permeases in Saccharomyces cerevisiae.

1983 • 59 citations

The PY-motif of Bul1 protein is essential for growth of Saccharomyces cerevisiae under various stress conditions

1998 • 58 citations

Genetic analysis of the signalling pathway activated by external amino acids in Saccharomyces cerevisiae

2001 • 58 citations

GNP1, the high-affinity glutamine permease of S. cerevisiae

1996 • 57 citations

Ureidosuccinate is transported by the allantoate transport system in Saccharomyces cerevisiae

1987 • 57 citations

Genetics and physiology of proline utilization in Saccharomyces cerevisiae: mutation causing constitutive enzyme expression

1979 • 56 citations

G1n3p is capable of binding to UAS(NTR) elements and activating transcription in Saccharomyces cerevisiae

1996 • 56 citations

Role of GATA factor Nil2p in nitrogen regulation of gene expression in Saccharomyces cerevisiae

1997 • 56 citations

Saccharomyces cerevisiae has a single glutamate synthase gene coding for a plant-like high-molecular-weight polypeptide

1995 • 54 citations

Mks1p Is a Regulator of Nitrogen Catabolism Upstream of Ure2p in Saccharomyces cerevisiae

1999 • 53 citations

Induction of the 4‐aminobutyrate and urea‐catabolic pathways in Saccharomyces cerevisiae

1990 • 52 citations

Phosphorylation Regulates the Interaction between Gln3p and the Nuclear Import Factor Srp1p

2001 • 52 citations

Saccharomyces cerevisiae Σ1278b Has Novel Genes of the N -Acetyltransferase Gene Superfamily Required for <scp>l</scp> -Proline Analogue Resistance

2000 • 52 citations

The role of ammonia metabolism in nitrogen catabolite repression in Saccharomyces cerevisiae

2000 • 51 citations

Two mutually exclusive regulatory systems inhibit UAS^GATA, a cluster of 5′-GAT(A/T)A-3′ upstream from theUGA4gene ofSaccharomyces cerevisiae

1995 • 51 citations

Functional Analysis of the PUT3 Transcriptional Activator of the Proline Utilization Pathway in Saccharomyces cerevisiae

1996 • 43 citations

Three regulatory systems control expression of glutamine synthetase inSaccharomyces cerevisiae at the level of transcription

1989 • 41 citations

THE GLN1 LOCUS OF SACCHAROMYCES CEREVISIAE ENCODES GLUTAMINE SYNTHETASE

1985 • 41 citations

Regulation of Glutamine Synthetase from Saccharomyces cerevisiae by Repression, Inactivation and Proteolysis

1982 • 40 citations

Lys80p ofSaccharomyces cerevisiae, previously proposed as a specific repressor ofLYS genes, is a pleiotropic regulatory factor identical to Mks1p

1997 • 40 citations

The Level of DAL80 Expression Down-Regulates GATA Factor-Mediated Transcription in Saccharomyces cerevisiae

2000 • 39 citations

Isolation and characterization of mutants that produce the allantoin-degrading enzymes constitutively in Saccharomyces cerevisiae.

1982 • 39 citations

Physiological Role of Glutaminase Activity in Saccharomyces cerevisiae

1987 • 36 citations

Integration of the multiple controls regulating the expression of the arginase gene CAR1 of Saccharomyces cerevisiae in response to different nitrogen signals: role of Gln3p, ArgRp-Mcm1p, and Ume6p

1997 • 33 citations

The ASP1 gene of Saccharomyces cerevisiae, encoding the intracellular isozyme of l-asparaginase

1994 • 26 citations

Nitrogen catabolite repression of arginase (CAR1) expression in Saccharomyces cerevisiae is derived from regulated inducer exclusion

1992 • 20 citations

Glutamine Degradation Through the -Amidase Pathway in Saccharomyces cerevisiae

1987 • 18 citations

Green Fluorescent Protein-Dal80p Illuminates up to 16 Distinct Foci That Colocalize with and Exhibit the Same Behavior as Chromosomal DNA Proceeding through the Cell Cycle of Saccharomyces cerevisiae

2001 • 6 citations