Hes6 acts in a positive feedback loop with the neurogenins to promote neuronal differentiation

Appendix G: In Situ Hybridization: An Improved Whole-Mount Method for Xenopus Embryos

1991 • 2,082 citations

Visualizing an Olfactory Sensory Map

1996 • 1,969 citations

Normal Table of Xenopus Laevis.

1968 • 1,185 citations

Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate.

1994 • 1,032 citations

Conversion of Xenopus Ectoderm into Neurons by NeuroD, a Basic Helix-Loop-Helix Protein

1995 • 1,028 citations

Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons

1993 • 1,019 citations

Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts

1999 • 919 citations

Solubilization and Purification of Enzymatically Active Glutathione S-Transferase (pGEX) Fusion Proteins

1993 • 891 citations

Identification of neurogenin, a Vertebrate Neuronal Determination Gene

1996 • 821 citations

Sox10, a Novel Transcriptional Modulator in Glial Cells

1998 • 759 citations

neurogenin1 Is Essential for the Determination of Neuronal Precursors for Proximal Cranial Sensory Ganglia

1998 • 731 citations

Symmetrical Mutant Phenotypes of the Receptor EphB4 and Its Specific Transmembrane Ligand ephrin-B2 in Cardiovascular Development

1999 • 708 citations

Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects.

1995 • 702 citations

Math1 is essential for genesis of cerebellar granule neurons

1997 • 687 citations

Primary neurogenesis in Xenopus embryos regulated by a homologue of the Drosophila neurogenic gene Delta

1995 • 669 citations

Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split.

1992 • 667 citations

Basic helix-loop-helix genes in neural development

1997 • 521 citations

Overexpression of Id protein inhibits the muscle differentiation program: in vivo association of Id with E2A proteins.

1992 • 480 citations

Generation of neurons by transient expression of neural bHLH proteins in mammalian cells

2000 • 474 citations

Induction of the prospective neural crest of Xenopus

1995 • 451 citations

The bHLH Protein NEUROGENIN 2 Is a Determination Factor for Epibranchial Placode–Derived Sensory Neurons

1998 • 439 citations

The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons

1995 • 403 citations

Persistent expression of helix-loop-helix factor HES-1 prevents mammalian neural differentiation in the central nervous system.

1994 • 395 citations

Skeletal muscle determination and differentiation: story of a core regulatory network and its context

1996 • 372 citations

Expression of an extracellular deletion of Xotch diverts cell fate in Xenopus embryos

1993 • 366 citations

Inhibition of Myogenic bHLH and MEF2 Transcription Factors by the bHLH Protein Twist

1996 • 328 citations

The bHLH GeneHes1as a Repressor of the Neuronal Commitment of CNS Stem Cells

2000 • 311 citations

A conserved family of elav-like genes in vertebrates.

1995 • 309 citations

Structure, chromosomal locus, and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-1. Negative autoregulation through the multiple N box elements.

1994 • 301 citations

Autoregulation and multiple enhancers control Math1 expression in the developing nervous system

2000 • 288 citations

The Xenopus homolog of Drosophila Suppressor of Hairless mediates Notch signaling during primary neurogenesis

1997 • 287 citations

Sympathetic neuroblasts undergo a developmental switch in trophic dependence

1993 • 279 citations

The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation

2000 • 259 citations

The activity of Neurogenin1 is controlled by local cues in the zebrafish embryo

1997 • 244 citations

The effects of N-cadherin misexpression on morphogenesis in xenopus embryos

1990 • 242 citations

The NGF-inducible SCG10 mRNA encodes a novel membrane-bound protein present in growth cones and abundant in developing neurons

1988 • 239 citations

X-MyT1, a Xenopus C2HC-Type Zinc Finger Protein with a Regulatory Function in Neuronal Differentiation

1996 • 236 citations

Early specification of sensory neuron fate revealed by expression and function of neurogenins in the chick embryo

1999 • 235 citations

Gli/Zic factors pattern the neural plate by defining domains of cell differentiation

1998 • 233 citations

Negative regulation of proneural gene activity: hairy is a direct transcriptional repressor of achaete.

1994 • 233 citations

Specificity for the Hairy/Enhancer of split Basic Helix-Loop-Helix (bHLH) Proteins Maps outside the bHLH Domain and Suggests Two Separable Modes of Transcriptional Repression

1995 • 223 citations

Brn-3.0 expression identifies early post-mitotic CNS neurons and sensory neural precursors

1995 • 223 citations

The function of hairy-related bHLH repressor proteins in cell fate decisions

1998 • 218 citations

Dorsal-ventral patterning and differentiation of noggin-induced neural tissue in the absence of mesoderm

1995 • 215 citations

Discrete Enhancer Elements Mediate Selective Responsiveness of Enhancer of split Complex Genes to Common Transcriptional Activators

1999 • 203 citations

Correct Coordination of Neuronal Differentiation Events in Ventral Forebrain Requires the bHLH Factor MASH1

1999 • 193 citations

A two-step mechanism generates the spacing pattern of the ciliated cells in the skin of Xenopus embryos

1999 • 193 citations

her4, a zebrafish homologue of the Drosophila neurogenic gene E(spl), is a target of NOTCH signalling

1999 • 188 citations

Spatial regulation of proneural gene activity: auto- and cross-activation of achaete is antagonized by extramacrochaetae.

1992 • 173 citations

MyoR: A muscle-restricted basic helix–loop–helix transcription factor that antagonizes the actions of MyoD

1999 • 169 citations

her1, a zebrafish pair-rule like gene, acts downstream of notch signalling to control somite development

1999 • 157 citations

ZEB, a vertebrate homolog of Drosophila Zfh-1, is a negative regulator of muscle differentiation

1997 • 147 citations

Conversion of ectoderm into a neural fate by ATH-3, a vertebrate basic helix-loop-helix gene homologous to Drosophila proneural gene atonal

1997 • 146 citations

Periodic repression of Notch pathway genes governs the segmentation of Xenopus embryos

1999 • 138 citations

XCoe2, a transcription factor of the Col/Olf-1/EBF family involved in the specification of primary neurons in Xenopus

1998 • 131 citations

XASH-3, a novel Xenopus achaete-scute homolog, provides an early marker of planar neural induction and position along the mediolateral axis of the neural plate

1993 • 125 citations

X-ngnr-1 and Xath3 promote ectopic expression of sensory neuron markers in the neurula ectoderm and have distinct inducing properties in the retina

1999 • 123 citations

XASH genes promote neurogenesis in Xenopus embryos

1994 • 118 citations

The Notch pathway: democracy and aristocracy in the selection of cell fate

1996 • 110 citations

A Xenopus homologue of aml-1 reveals unexpected patterning mechanisms leading to the formation of embryonic blood

1998 • 109 citations

Localization of a nervous system-specific class II beta-tubulin gene in Xenopus laevis embryos by whole-mount in situ hybridization.

1991 • 105 citations

Mediation of NGF signaling by post-translational inhibition of HES-1, a basic helix–loop–helix repressor of neuronal differentiation

1997 • 101 citations

Hensen’s node induces neural tissue in Xenopus ectoderm. Implications for the action of the organizer in neural induction

1991 • 98 citations

Drosophila short gastrulation induces an ectopic axis in Xenopus: evidence for conserved mechanisms of dorsal-ventral patterning

1995 • 76 citations

Activation of Xenopus Genes Required for Lateral Inhibition and Neuronal Differentiation during Primary Neurogenesis

1999 • 72 citations

Functional dissection of the Drosophila Enhancer of split protein, a suppressor of neurogenesis

1997 • 68 citations

Regulation of hippocampal neuronal differentiation by the basic helix-loop-helix transcription factors HES-1 and MASH-1

1999 • 63 citations

Patterning of the adult peripheral nervous system of Drosophila.

1997 • 61 citations

Regulation of neurogenesis by interactions between HEN1 and neuronal LMO proteins

2000 • 49 citations

In vivo interactions of the Drosophila Hairy and Runt transcriptional repressors with target promoters.

1996 • 47 citations