Modulation of Renal Disease in MRL/lpr Mice by Suberoylanilide Hydroxamic Acid

NITRIC OXIDE AND MACROPHAGE FUNCTION

1997 • 4,106 citations

Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains.

1978 • 1,619 citations

Histone Deacetylase Inhibitors: Inducers of Differentiation or Apoptosis of Transformed Cells

2000 • 1,158 citations

A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases

1998 • 899 citations

Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes

2001 • 729 citations

The expression of a small fraction of cellular genes is changed in response to histone hyperacetylation.

1996 • 662 citations

Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses the growth of prostate cancer cells in vitro and in vivo.

2000 • 608 citations

Role of interferon regulatory factor 1 in induction of nitric oxide synthase.

1994 • 477 citations

Peroxynitrite, the coupling product of nitric oxide and superoxide, activates prostaglandin biosynthesis

1996 • 428 citations

Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo.

2001 • 422 citations

Control of muscle development by dueling HATs and HDACs

2001 • 405 citations

Histone deacetylase inhibitors modulate renal disease in the MRL-lpr/lpr mouse

2003 • 385 citations

The role of B cells in lpr/lpr-induced autoimmunity.

1994 • 356 citations

Interferon-gamma is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice.

1998 • 354 citations

Decoding the nucleosome

1993 • 342 citations

Role of covalent modifications of histones in regulating gene expression

1999 • 305 citations

Activation of MHC Class I, II, and CD40 Gene Expression by Histone Deacetylase Inhibitors

2000 • 279 citations

IFN-gamma is essential for the development of autoimmune glomerulonephritis in MRL/Ipr mice.

1997 • 254 citations

IFN-gamma receptor signaling is essential for the initiation, acceleration, and destruction of autoimmune kidney disease in MRL-Fas(lpr) mice.

1998 • 247 citations

B cells process and present lupus autoantigens that initiate autoimmune T cell responses.

1994 • 236 citations

Activation of the p21WAF1/CIP1 promoter independent of p53 by the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) through the Sp1 sites

2000 • 217 citations

The cell cycle inhibitor p21 controls T-cell proliferation and sex-linked lupus development

2000 • 197 citations

Prevention of nephritis in major histocompatibility complex class II-deficient MRL-lpr mice.

1994 • 194 citations

An IFN-γ-Inducible Transcription Factor, IFN Consensus Sequence Binding Protein (ICSBP), Stimulates IL-12 p40 Expression in Macrophages

2000 • 185 citations

Trichostatin A reverses skewed expression of CD154, interleukin-10, and interferon-γ gene and protein expression in lupus T cells

2001 • 179 citations

p65-activated Histone Acetyltransferase Activity Is Repressed by Glucocorticoids

2001 • 137 citations

The role of interleukin 12 and nitric oxide in the development of spontaneous autoimmune disease in MRL/MP-lpr/lpr mice.

1996 • 128 citations

Histone Deacetylases Augment Cytokine Induction of the iNOS Gene

2002 • 108 citations

Factor-specific modulation of CREB-binding protein acetyltransferase activity

1999 • 105 citations

Histone Deacetylase Inhibitor Activates the p21/WAF1/Cip1 Gene Promoter through the Sp1 Sites

1999 • 103 citations

Enhanced MHC class II expression in renal proximal tubules precedes loss of renal function in MRL/lpr mice with lupus nephritis.

1989 • 100 citations

Cellular interactions in the pathogenesis of lupus nephritis: The role of T cells and macrophages in the amplification of the inflammatory process in the kidney

1998 • 91 citations

Inhibition of histone deacetylase activity by trichostatin A modulates gene expression during mouse embryogenesis without apparent toxicity.

2001 • 88 citations

Role of IL-12 in macrophage activation during intracellular infection: IL-12 and mycobacteria synergistically release TNF-alpha and nitric oxide from macrophages via IFN-gamma induction.

2000 • 83 citations

Expression of inducible-NOS in human glomerulonephritis: The possible source is infiltrating monocytes/macrophages

1996 • 83 citations

Role of IL-12 in macrophage activation during intracellular infection: IL-12 and mycobacteria synergistically release TNF-α and nitric oxide from macrophages via IFN-γ induction

2000 • 82 citations

Inhibition of Mesangial Cell Nitric Oxide in MRL/lpr Mice by Prostaglandin J2 and Proliferator Activation Receptor-γ Agonists

2000 • 73 citations

Histone Deacetylase Inhibitors Promote Apoptosis and Differential Cell Cycle Arrest in Anaplastic Thyroid Cancer Cells

2001 • 69 citations

Mechanisms and modulation of macrophage activation.

1991 • 63 citations

Functional characteristics of macrophages in glomerulonephritis in the rat. O2- generation, MHC class II expression, and eicosanoid synthesis.

1989 • 59 citations

Prostaglandin J2 Inhibition of Mesangial Cell iNOS Expression

2001 • 55 citations

Inducible nitric oxide synthase in inflammation

1995 • 49 citations

Acetylation of MyoD by p300 Requires More Than Its Histone Acetyltransferase Domain

2001 • 41 citations

Induction of nonpathologic, humoral autoimmunity in lupus-prone mice by a class II-restricted, transgenic alpha beta T cell. Separation of autoantigen-specific and -nonspecific help.

1996 • 39 citations

T cells in murine lupus: propagation and regulation of disease

1996 • 37 citations

A golgi study of dendritic morphology in the occipital cortex of socially reared aged rats

1981 • 33 citations

Upregulation of lymphoid and renal interferon-gamma mRNA in autoimmune MRL-Fas(lpr) mice with lupus nephritis.

1997 • 30 citations

Crescentic glomerulonephritis in interferon-gamma receptor deficient mice.

1995 • 21 citations

Detection of glomerular-binding immune elements in murine lupus using a tissue-based ELISA

1993 • 19 citations

MHC class I pathway is not required for the development of crescentic glomerulonephritis in mice

2000 • 14 citations

Excessive expression of the tumor necrosis factor-alpha gene in the kidneys of patients with membranous glomerulonephritis.

1998 • 7 citations

Complement factor C3 is not required for full expression of lupus nephritis in MRL/lpr mice

2000 • 2 citations