Regio- and Stereoselectivity of Hepatic Cytochrome P-450 Toward Polycyclic Aromatic Hydrocarbon Substrates

Separation and characterization of highly purified forms of liver microsomal cytochrome P-450 from rats treated with polychlorinated biphenyls, phenobarbital, and 3-methylcholanthrene.

1979 • 576 citations

Tumorigenicity of the optical enantiomers of the diastereomeric benzo[a]pyrene 7,8-diol-9,10-epoxides in newborn mice: exceptional activity of (+)-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.

1978 • 380 citations

Polynuclear aromatic hydrocarbons : chemistry and biological effects

1980 • 340 citations

Regulation of three forms of cytochrome P-450 and epoxide hydrolase in rat liver microsomes. Effects of age, sex, and induction.

1981 • 304 citations

Enzymatic conversion of benzo(a)pyrene leading predominantly to the diol-epoxide r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene through a single enantiomer of r-7, t-8-dihydroxy-7,8-dihydrobenzo(a)pyrene.

1976 • 270 citations

Metabolism of benzo[a]pyrene VI. Stereoselective metabolism of benzo[a]pyrene and benzo[a]pyrene 7,8-dihydrodiol to diol epoxides

1977 • 263 citations

Drug metabolism from microbe to man

1977 • 255 citations

Effects of Inducers and Epoxide Hydrase on the Metabolism of Benzo[ a ]pyrene by Liver Microsomes and a Reconstituted System: Analysis by High Pressure Liquid Chromatography

1974 • 212 citations

Molecular Basis of Environmental Toxicity

1981 • 167 citations

Metabolism of benzo[a]pyrene

1975 • 148 citations

Enzymic mechanism of benzo[a]pyrene conversion to phenols and diols and an improved high-pressure liquid chromatographic separation of benzo[a]pyrene derivatives

1977 • 103 citations

Metabolism of chrysene and phenanthrene to bay-region diol epoxides by rat liver enzymes.

1981 • 98 citations

Evidence that benzo(a)anthracene 3,4-diol-1,2-epoxide is an ultimate carcinogen on mouse skin.

1978 • 94 citations

Mutagenicity and cytotoxicity of benz[ a ]anthracene diol epoxides and tetrahydro-epoxides: Exceptional activity of the bay region 1,2-epoxides

1977 • 93 citations

Regio- and stereoselectivity of various forms of purified cytochrome P -450 in the metabolism of benzo[ a ]pyrene and (-) trans -7,8-dihydroxy-7,8-dihydrobenzo[ a ]pyrene as shown by product formation and binding to DNA

1978 • 91 citations

An enantiomeric interaction in the metabolism and tumorigenicity of (+)- and (-)-benzo[a]pyrene 7,8-oxide.

1980 • 86 citations

Stereospecificity of microsomal and purified epoxide hydrase from rat liver. Hydration of arene oxides of polycyclic hydrocarbons.

1977 • 79 citations

Molecular basis of environmental toxicity

1980 • 72 citations

Marked differences in the carcinogenic activity of optically pure (+)- and (-)-trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene in newborn mice.

1978 • 59 citations

Absolute stereochemistry of the trans-dihydrodiols formed from benzo[a]anthracene by liver microsomes

1979 • 47 citations

Enantioselectivity of microsomal epoxide hydrolase toward arene oxide substrates.

1981 • 45 citations

Metabolism of benzo[a]anthracene to its tumorigenic 3,4-dihydrodiol.

1979 • 41 citations

The highly tumorigenic 3,4-dihydrodiol is a principal metabolite formed from dibenzo[a,h]anthracene by liver enzymes.

1979 • 40 citations

Tumorigenicity of the Diastereomeric Benz[<italic>a</italic>]anthracene 3,4-Diol-1,2-epoxides and the (+)- and (−)-Enantiomers of Benz[<italic>a</italic>]anthracene 3,4-Dihydrodiol in Newborn Mice

1979 • 32 citations

Stereoselective Metabolic Activation of Polycyclic Aromatic Hydrocarbons

1979 • 30 citations

Catalytic activity and stereoselectivity of purified forms of rabbit liver microsomal cytochrome P-450 in the oxygenation of the (-) and (+) enantiomers of trans-7,8-dihydroxy-7,8-dihydrobenzo[alpha]pyrene.

1979 • 28 citations

Metabolism of benzo(e)pyrene by rat liver microsomal enzymes

1980 • 26 citations

Tumor initiating and promoting activities of various benzo(a)pyrene metabolites in mouse skin

1977 • 23 citations

absolute configuration of the k-region 4,5-dihydrodiols and 4,5-oxide of benzo[a]pyrene

1981 • 22 citations

Biological Activity of Polycyclic Hydrocarbon Metabolites and the Bay Region Theory

1979 • 18 citations

Polynuclear Aromatic Hydrocarbons: Second International Symposium on Analysis, Chemistry, and Biology

1978 • 7 citations