Modulation of rhodopsin function by properties of the membrane bilayer

Intermolecular and Surface Forces

2011 • 17,408 citations

Physical chemistry of surfaces

1998 • 11,723 citations

Intermolecular and Surface Forces

2011 • 7,781 citations

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

Physical chemistry of surfaces

1991 • 2,840 citations

Protein Denaturation

1968 • 2,108 citations

Protein Folding

1992 • 1,601 citations

Electrostatic Interactions in Macromolecules: Theory and Applications

1990 • 1,324 citations

Structure of the inverted hexagonal (HII) phase, and non-lamellar phase transitions of lipids

1990 • 1,056 citations

The Electrostatic Properties of Membranes

1989 • 1,032 citations

G Proteins: A Family of Signal Transducers

1986 • 975 citations

Preferred conformation and molecular packing of phosphatidylethanolamine and phosphatidylcholine

1981 • 883 citations

The Molecular Basis of Visual Excitation

1968 • 813 citations

Projection structure of rhodopsin

1993 • 758 citations

Mattress model of lipid-protein interactions in membranes

1984 • 734 citations

Dietary omega-3 fatty acid deficiency and visual loss in infant rhesus monkeys.

1984 • 653 citations

Distribution and fatty acid composition of phosphoglycerides in normal human brain

1968 • 623 citations

Tautomeric Forms of Metarhodopsin

1963 • 602 citations

Health Effects of Polyunsaturated Fatty Acids in Seafoods

1986 • 565 citations

Visual excitation and recovery

1991 • 530 citations

A case of human linolenic acid deficiency involving neurological abnormalities

1982 • 529 citations

Cubic phases and isotropic structures formed by membrane lipids — possible biological relevance

1989 • 525 citations

Photophysics and Molecular Electronic Applications of the Rhodopsins

1990 • 516 citations

Site of G Protein Binding to Rhodopsin Mapped with Synthetic Peptides from the α Subunit

1988 • 491 citations

Fatty acid and fatty aldehyde composition of the major brain lipids in normal human gray matter, white matter, and myelin

1965 • 471 citations

Rhodopsin Mutants That Bind But Fail to Activate Transducin

1990 • 377 citations

Visual Membranes: Specificity of Fatty Acid Precursors for the Electrical Response to Illumination

1975 • 370 citations

Stability of lyotropic phases with curved interfaces

1989 • 365 citations

The properties of polyunsaturated lecithins in monolayers and liposomes and the interactions of these lecithins with cholesterol

1972 • 339 citations

Rhodopsin and phototransduction: a model system for G protein‐linked receptors

1992 • 332 citations

Determinants of visual pigment absorbance: identification of the retinylidene Schiff's base counterion in bovine rhodopsin

1990 • 319 citations

Membrane Fatty Acids Associated with the Electrical Response in Visual Excitation

1973 • 317 citations

Molecular mechanism of visual transduction

1989 • 312 citations

Membrane curvature, lipid segregation, and structural transitions for phospholipids under dual-solvent stress

1990 • 291 citations

Models of Lipid-Protein Interactions in Membranes

1993 • 273 citations

THE MOLECULAR MECHANISM OF VISUAL EXCITATION AND ITS RELATION TO THE STRUCTURE AND COMPOSITION OF THE ROD OUTER SEGMENT

1987 • 264 citations

A single amino acid substitution in rhodopsin (lysine 248—-leucine) prevents activation of transducin.

1988 • 260 citations

Cyclic GMP and calcium: The internal messengers of excitation and adaptation in vertebrate photoreceptors

1990 • 258 citations

Lipid requirements for rhodopsin regenerability

1973 • 250 citations

The intrinsic pKa values for phosphatidylserine and phosphatidylethanolamine in phosphatidylcholine host bilayers

1986 • 248 citations

The structure of rhodopsin and the rod outer segment disk membrane

1983 • 248 citations

Lipid composition of synaptic plasma membranes isolated from rat brain by zonal centrifugation

1969 • 248 citations

Essential fatty acids and eicosanoids

1993 • 239 citations

A reinvestigation of the fatty acid content of bovine, rat and frog retinal rod outer segments

1979 • 232 citations

The role of G proteins in transmembrane signalling

1990 • 228 citations

Rhodopsin. Purification and recombination with phospholipids assayed by the metarhodopsin I .far. metarhodopsin II transition

1974 • 214 citations

Modulation of metarhodopsin formation by cholesterol-induced ordering of bilayer lipids

1990 • 206 citations

Trigger and Amplification Mechanisms in Visual Phototransduction

1985 • 196 citations

Effect of lipid composition on the calcium/adenosine 5'-triphosphate coupling ratio of the calcium(2+)-ATPase of sarcoplasmic reticulum

1984 • 193 citations

The effect of bilayer thickness and n-alkanes on the activity of the (Ca2+ + Mg2+)-dependent ATPase of sarcoplasmic reticulum.

1981 • 182 citations

Lipid headgroup and acyl chain composition modulate the MI-MII equilibrium of rhodopsin in recombinant membranes

1993 • 178 citations

Isotropic bicontinuous solutions in surfactant-Solvent systems: the L3 phase

1989 • 178 citations

Computer-based modeling of the conformation and packing properties of docosahexaenoic acid.

1988 • 175 citations

Quantification and fatty acid and fatty aldehyde composition of ethanolamine, choline, and serine glycerophosphatides in human cerebral grey and white matter

1964 • 168 citations

Lipid-protein interactions mediate the photochemical function of rhodopsin

1988 • 165 citations

Disaturated and dipolyunsaturated phospholipids in the bovine retinal rod outer segment disk membrane

1979 • 160 citations

Polyunsaturated fatty acids of photoreceptor membranes

1974 • 147 citations

Photochemical functionality of rhodopsin-phospholipid recombinant membranes

1977 • 142 citations

Effects of lipid environment on the light-induced conformational changes of rhodopsin. 2. Roles of lipid chain length, unsaturation, and phase state

1985 • 132 citations

Effects of detergents and high pressures upon the metarhodopsin I.dbr.metarhodopsin II equilibrium

1974 • 118 citations

Temperature and pH dependence of the metarhodopsin I-metarhodopsin II kinetics and equilibria in bovine rod disk membrane suspensions

1984 • 117 citations

Configurational statistics of acyl chains in polyunsaturated lipid bilayers from deuterium NMR

1987 • 117 citations

Chapter 1 Rhodopsin chemistry, structure and topography

1982 • 115 citations

Molecular aspects of photoreceptor function

1975 • 114 citations

Molecular areas of phospholipids as determined by 2H NMR spectroscopy. Comparison of phosphatidylethanolamines and phosphatidylcholines

1991 • 114 citations

The Molecules of Visual Excitation

1987 • 109 citations

Interconversion of metarhodopsins I and II: a branched photointermediate decay model

1990 • 106 citations

Spin-label saturation-transfer electron spin resonance detection of transient association of rhodopsin in reconstituted membranes

1982 • 94 citations

Effects of lipid environment on the light-induced conformational changes of rhodopsin. 1. Absence of metarhodopsin II production in dimyristoylphosphatidylcholine recombinant membranes

1985 • 94 citations

Functional equivalence of metarhodopsin II and the Gt-activating form of photolyzed bovine rhodopsin

1991 • 92 citations

The asymmetric transmembrane distribution of phosphatidylethanolamine, phosphatidylserine, and fatty acids of the bovine retinal rod outer segment disk membrane

1981 • 89 citations

Thermotropic behavior of retinal rod membranes and dispersions of extracted phospholipids

1985 • 82 citations

Decreased content of docosahexaenoate and arachidonate in plasma phospholipids in usher's syndrome

1986 • 79 citations

Organization of rhodopsin in photoreceptor membranes. 2. Transmembrane organization of bovine rhodopsin: evidence from proteolysis and lactoperoxidase-catalyzed iodination of native and reconstituted membranes

1978 • 78 citations

Bilayer bending rigidity of some synthetic lecithins

1985 • 76 citations

The orientation of the chromophore of vertebrate rhodopsin in the “meta” intermediate states and the reversibility of the meta II-meta III transition

1979 • 73 citations

Interpretation of 100- and 360-MHz proton magnetic resonance spectra of retinal rod outer segment disk membranes

1977 • 66 citations

ORIENTATION OF AROMATIC RESIDUES IN RHODOPSIN. ROTATION OF ONE TRYPTOPHAN UPON THE META I→META II TRANSITION AFTER ILLUMINATION

1979 • 63 citations

Light-dependent conformational change at rhodopsin's cytoplasmic surface detected by increased susceptibility to proteolysis

1982 • 61 citations

Effect of lipid membrane structure on the adenosine 5'-triphosphate hydrolyzing activity of the calcium-stimulated adenosinetriphosphatase of sarcoplasmic reticulum

1981 • 61 citations

LIGHT‐INDUCED PERTURBATION OF AROMATIC RESIDUES IN BOVINE RHODOPSIN AND BACTERIORHODOPSIN*

1979 • 60 citations

Abnormal plasma levels of polyunsaturated fatty acid in autosomal dominant retinitis pigmentosa

1987 • 60 citations

Evidence for rhodopsin refolding during the decay of Meta II

1987 • 58 citations

Retinal rod outer segment lipids form bilayers in the presence and absence of rhodopsin: a ³¹P NMR study

1981 • 53 citations

Distribution of charge on photoreceptor disc membranes and implications for charged lipid asymmetry

1990 • 51 citations

Reactions of the Sulfhydryl Groups of Membrane-Bound Bovine Rhodopsin

1978 • 50 citations

Low-temperature deuterium NMR spectroscopy of phospholipid bilayers containing docosahexaenoyl (22:6.omega.3) chains

1991 • 43 citations

Rhodopsin-phospholipid interactions: dependence of rate of the meta I to meta II transition on the level of associated disk phospholipid

1981 • 40 citations

PHOTOLYSIS OF RHODOPSIN RESULTS IN DEPROTONATION OF ITS RETINAL SCHIFF'S BASE PRIOR TO FORMATION OF METARHODOPSIN II

1992 • 37 citations

Characterization of rhodopsin in synthetic systems

1975 • 37 citations

KINETICS OF RHODOPSIN PHOTOLYSIS INTERMEDIATES IN RETINAL ROD DISK MEMBRANES—I. TEMPERATURE DEPENDENCE OF LUMIRHODOPSIN AND METARHODOPSIN I KINETICS

1981 • 35 citations

Optical Study of the Light‐Induced Protonation Changes Associated with the Metarhodopsin II Intermediate in Rod‐Outer‐Segment Membranes

1980 • 35 citations

MEMBRANE LIPID INFLUENCES ON THE ENERGETICS OF THE METARHODOPSIN I and METARHODOPSIN II CONFORMATIONAL STATES OF RHODOPSIN PROBED BY FLASH PHOTOLYSIS*

1991 • 33 citations

[96] Proton, carbon-13, and phosphorus-31 NMR methods for the investigation of rhodopsin-lipid interactions in retinal rod outer segment membranes

1982 • 32 citations

Bilayers of arachidonic acid containing phospholipids studied by deuterium and phosphorus-31 NMR spectroscopy

1991 • 32 citations

Role of phosphatidylserine in the MI-MIII equilibrium of rhodopsin

1991 • 32 citations

Chemistry and Biochemistry of Unsaturated Fatty Acids

1976 • 32 citations

Clinical and Serum Lipid Findings in a Large Family with Autosomal Dominant Retinitis Pigmentosa

1988 • 26 citations

Covalent modification of rhodopsin with imidoesters: evidence for transmembrane arrangement of rhodopsin in rod outer segment disk membranes

1980 • 25 citations

STUDIES OF RHODOPSIN AND BACTERIORHODOPSIN USING MODIFIED RETINALS

1986 • 25 citations

Influences of membrane curvature in lipid hexagonal phases studied by deuterium NMR spectroscopy

1990 • 18 citations

KINETICS OF RHODOPSIN PHOTOLYSIS INTERMEDIATES IN RETINAL ROD DISK MEMBRANES—I. TEMPERATURE DEPENDENCE OF LUMIRHODOPSIN AND METARHODOPSIN I KINETICS

1981 • 18 citations

Influence of pH on the MI-MII equilibrium of rhodopsin in recombinant membranes

1990 • 17 citations

Metabolic labeling of rod outer segment phospholipids in miniature poodles with progressive rod-cone degeneration (prcd)

1990 • 15 citations

Surface and colloid chemistry of peat and peat dewatering. Electrostatic effects

1988 • 14 citations

Hydrogen exchange study of membrane-bound rhodopsin. II. Light-induced protein structure change.

1977 • 11 citations

Kinetic studies on the formation and decay of metarhodopsins from bovine retinas

1984 • 8 citations

Amino acid sequence adjacent to a sulfhydryl group exposed on illumination of bovine rhodopsin.

1981 • 7 citations

Effect of photoregeneration on the calculation of the amount of rhodopsin bleached by small flashes

1994 • 7 citations

Role of Chemistry in Biotechnology And Materials Science Highlighted

1987 • 7 citations

The Chemistry of VISION

1983 • 5 citations

Correction - Low-Temperature ²H NMR Spectroscopy of Phospholipid Bilayers Containing Docosahexenoyl (22:6ι3) Chains.

1992 • 3 citations

Plasma lipids in retinitis pigmentosa

1987 • 3 citations