Leptin-Induced Changes in Body Composition in High Fat-Fed Mice¹

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans

1996 • 6,254 citations

Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

1995 • 3,302 citations

The Leptin Receptor

1997 • 1,300 citations

Divergent Signaling Capacities of the Long and Short Isoforms of the Leptin Receptor

1997 • 907 citations

Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity

2000 • 873 citations

Diet-induced obese mice develop peripheral, but not central, resistance to leptin.

1997 • 750 citations

Modulation of Insulin Activities by Leptin

1996 • 733 citations

Acute stimulation of glucose metabolism in mice by leptin treatment

1997 • 717 citations

Direct antidiabetic effect of leptin through triglyceride depletion of tissues

1997 • 664 citations

Leptin Impairs Metabolic Actions of Insulin in Isolated Rat Adipocytes

1997 • 463 citations

Regulation of fatty acid homeostasis in cells: Novel role of leptin

1999 • 442 citations

Leptin increases uncoupling protein expression and energy expenditure

1997 • 396 citations

A Leptin Dose-Response Study in Obese (ob/ob) and Lean (+/?) Mice

1998 • 296 citations

Effects of Leptin on Insulin Sensitivity in Normal Rats*

1997 • 271 citations

In VitroLipolytic Effect of Leptin on Mouse Adipocytes: Evidence for a Possible Autocrine/Paracrine Role of Leptin

1997 • 264 citations

In Vivo Administration of Leptin Activates Signal Transduction Directly in Insulin-Sensitive Tissues: Overlapping but Distinct Pathways from Insulin*

2000 • 234 citations

Leptin stimulates glucose transport and glycogen synthesis in C 2 C 12 myotubes: evidence for a PI3-kinase mediated effect

1997 • 207 citations

Leptin activates PI-3 kinase in C2C12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways

1997 • 204 citations

Chronic central leptin infusion enhances insulin-stimulated glucose metabolism and favors the expression of uncoupling proteins.

1998 • 197 citations

Selective interaction between leptin and insulin signaling pathways in a hepatic cell line

2000 • 189 citations

Leptin Induces Mitogen-activated Protein Kinase- dependent Proliferation of C3H10T1/2 Cells

1997 • 187 citations

Partial saturation and regional variation in the blood-to-brain transport of leptin in normal weight mice

2000 • 157 citations

Morphologic and molecular changes induced by recombinant human leptin in the white and brown adipose tissues of C57BL/6 mice.

1997 • 98 citations

Acute and Chronic Effects of Leptin on Glucose Utilization in Lean Mice

1998 • 77 citations

Cyclical Variations in the Abundance of Leptin Receptors, but not in Circulating Leptin, Correlate with NPY Expression during the Oestrous Cycle

1999 • 73 citations

Differential Expression of Leptin Receptor in High‐ and Low‐Fat‐Fed Osborne‐Mendel and S5B/Pl Rats

2000 • 58 citations

Obesity due to high fat diet decreases the sympathetic nervous and cardiovascular responses to intracerebroventricular leptin in rats

1998 • 57 citations

The IRS-signalling system in insulin and cytokine action

1996 • 55 citations

Hyperleptinemia Depletes Fat from Denervated Fat Tissue

1999 • 53 citations

Growth Measurements in Sprague-Dawley Rats Fed Diets of Very Low Fat Concentration

1991 • 52 citations

The Relationship of Tissue Localization, Distribution and Turnover to Feeding After Intraperitoneal¹²⁵I-Leptin Administration toob/obanddb/dbMice

1996 • 51 citations

Leptin does not affect adipocyte glucose metabolism: Studies in fresh and cultured adipocytes

1998 • 28 citations