Exogenous E2F expression is growth inhibitory before, during, and after cellular transformation

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185

1986 • 1,020 citations

Suppression of the Neoplastic Phenotype by Replacement of the RB Gene in Human Cancer Cells

1988 • 832 citations

E2F-1 Functions in Mice to Promote Apoptosis and Suppress Proliferation

1996 • 765 citations

Tumor Induction and Tissue Atrophy in Mice Lacking E2F-1

1996 • 704 citations

Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein.

1993 • 531 citations

Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation.

1993 • 498 citations

Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase

1994 • 493 citations

Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein.

1993 • 460 citations

The retinoblastoma protein binds to a family of E2F transcription factors.

1993 • 436 citations

Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint

1995 • 361 citations

Interaction of Sp1 with the Growth- and Cell Cycle-Regulated Transcription Factor E2F

1996 • 343 citations

E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo.

1994 • 329 citations

Interaction between ubiquitin–protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation

1999 • 317 citations

E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction.

1997 • 284 citations

Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation.

1994 • 283 citations

Cell Cycle-Regulated Association of E2F1 and Sp1 Is Related to Their Functional Interaction

1996 • 268 citations

Induction of DNA synthesis and apoptosis are separable functions of E2F-1.

1997 • 266 citations

Oncogenic capacity of the E2F1 gene.

1994 • 254 citations

The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase

1998 • 253 citations

A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites.

1995 • 248 citations

In Vivo Association of E2F and DP Family Proteins

1995 • 246 citations

E2F Activity Is Regulated by Cell Cycle-Dependent Changes in Subcellular Localization

1997 • 228 citations

Overexpression of E2F-1 in rat embryo fibroblasts leads to neoplastic transformation.

1994 • 214 citations

Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F.

1993 • 196 citations

Induction of S-Phase Entry by E2F Transcription Factors Depends on Their Nuclear Localization

1997 • 195 citations

The subcellular localization of E2F-4 is cell-cycle dependent

1997 • 193 citations

Increased E2F1 activity induces skin tumors in mice heterozygous and nullizygous for p53

1998 • 159 citations

The transforming domain alone of the latent membrane protein of Epstein-Barr virus is toxic to cells when expressed at high levels

1989 • 157 citations

E2F1 Has Both Oncogenic and Tumor-Suppressive Properties in a Transgenic Model

1999 • 152 citations

Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members

1996 • 151 citations

Inhibition of E2F-1 Transactivation by Direct Binding of the Retinoblastoma Protein

1993 • 151 citations

Deregulated expression of E2F1 induces hyperplasia and cooperates with ras in skin tumor development

1998 • 138 citations

Regulation of two E2F-related genes in presenescent and senescent human fibroblasts.

1994 • 121 citations

A genetic analysis of the E2F1 gene distinguishes regulation by Rb, p107, and adenovirus E4.

1993 • 118 citations

The Us9 Gene Product of Pseudorabies Virus, an Alphaherpesvirus, Is a Phosphorylated, Tail-Anchored Type II Membrane Protein

1998 • 112 citations

Amplification of the E2F1 transcription factor gene in the HEL erythroleukemia cell line

1995 • 85 citations

Cyclin A/CDK2 Binds Directly to E2F-1 and Inhibits the DNA-Binding Activity of E2F-1/DP-1 by Phosphorylation

1994 • 81 citations

An Integral Membrane Green Fluorescent Protein Marker, Us9-GFP, Is Quantitatively Retained in Cells during Propidium Iodide-Based Cell Cycle Analysis by Flow Cytometry

1999 • 62 citations

Protein-DNA Interactions at the Major and Minor Promoters of the Divergently Transcribed dhfr and rep3 Genes during the Chinese Hamster Ovary Cell Cycle

1996 • 55 citations

E2F-3 accumulation is regulated by polypeptide stability

1998 • 19 citations

RAS enzyme-linked immunoblot assay discriminates p21 species: A technique to dissect gene family expression

1989 • 17 citations