Proteolytic Activation of the Interleukin-1β Precursor byCandida albicans

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm

1994 • 7,068 citations

Candida and candidosis

1979 • 1,326 citations

The Role of Interleukin-1 in Disease

1993 • 967 citations

POTENTIATION OF THE T-LYMPHOCYTE RESPONSE TO MITOGENS

1972 • 921 citations

POTENTIATION OF THE T-LYMPHOCYTE RESPONSE TO MITOGENS

1972 • 742 citations

Biological properties of interleukin 10

1992 • 656 citations

PUTATIVE VIRULENCE FACTORS OF CANDIDA ALBICANS

1991 • 632 citations

Identification of a monocyte specific pre-interleukin 1 beta convertase activity.

1989 • 501 citations

Generation of biologically active interleukin-1 beta by proteolytic cleavage of the inactive precursor.

1988 • 377 citations

Expression of seven members of the gene family encoding secretory aspartyl proteinases in Candida albicans

1994 • 374 citations

Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase.

1991 • 326 citations

The biological properties of interleukin-1.

1994 • 320 citations

Denture Stomatitis I. The Etiology in Relation to Trauma and Infection

1970 • 320 citations

An epidemiologic study of yeasts in elderly denture wearers

1975 • 292 citations

Cleavage of interleukin 1 beta (IL-1 beta) precursor to produce active IL-1 beta by a conserved extracellular cysteine protease from Streptococcus pyogenes.

1993 • 254 citations

Multiplicity of genes encoding secreted aspartic proteinases in Candida species

1994 • 251 citations

Expression of extracellular acid proteinase by proteolytic Candida spp. during experimental infection of oral mucosa

1988 • 228 citations

Granzyme A is an interleukin 1 beta-converting enzyme.

1995 • 217 citations

Processing of precursor interleukin 1 beta and inflammatory disease.

1990 • 217 citations

Interleukin 1 is present in normal human epidermis.

1986 • 214 citations

Candida albicans secreted aspartyl proteinases: isoenzyme pattern is determined by cell type, and levels are determined by environmental factors

1995 • 211 citations

Human keratinocytes produce but do not process pro-interleukin-1 (IL-1) beta. Different strategies of IL-1 production and processing in monocytes and keratinocytes.

1991 • 209 citations

Candida albicans: a review of its history, taxonomy, epidemiology, virulence attributes, and methods of strain differentiation

1996 • 185 citations

The Interleukin-1 Axis and Cutaneous Inflammation

1995 • 163 citations

Three distinct secreted aspartyl proteinases in Candida albicans

1993 • 163 citations

Transcription of the gene for a pepsinogen, PEP1, is regulated by white-opaque switching in Candida albicans.

1992 • 158 citations

Evidence for degradation of gastrointestinal mucin by Candida albicans secretory aspartyl proteinase

1996 • 152 citations

Isolation and Characterization of Proteinase from Candida albicans: Substrate Specificity

1984 • 143 citations

Mechanisms of leukocyte motility and chemotaxis

1994 • 136 citations

Elevated aspartic proteinase secretion and experimental pathogenicity of Candida albicans isolates from oral cavities of subjects infected with human immunodeficiency virus

1996 • 123 citations

Characteristic Cytokines Generated by Keratinocytes and Mononuclear Infiltrates in Oral Lichen Planus

1995 • 118 citations

Candidaacid proteinases

1992 • 100 citations

Agglutination of Blastospores of Candida albicans by Concanavalin A and its Relationship with the Distribution of Mannan Polymers and the Ultrastructure of the Cell Wall

1978 • 95 citations

Denture stomatitis. I.

1979 • 94 citations

A second gene for a secreted aspartate proteinase in Candida albicans

1992 • 90 citations

Isolation and characteristics of collagenolytic enzyme produced by Candida albicans

1986 • 85 citations

Cleavage of immunoglobulins by pathogenic yeasts of the genus Candida.

1986 • 83 citations

Experimental Cutaneous Candidiasis In Rodents

1976 • 81 citations

Candida-associated denture stomatitis and angular cheilitis.

1990 • 77 citations

Activation of the plasma kallikrein-kinin system by Candida albicans proteinase

1990 • 74 citations

Localization and Characterization of the Interleukin 1 Immunoreactive Pool (IL-1 alpha and beta Forms) in Normal Human Epidermis

1989 • 72 citations

Analysis of secreted aspartic proteinases from Candida albicans: purification and characterization of individual Sap1, Sap2 and Sap3 isoenzymes

1997 • 70 citations

Oral Mucosa in Health and Disease

2018 • 66 citations

Rapid presumptive identification of black-pigmented gram-negative anaerobic bacteria by using 4-methylumbelliferone derivatives

1991 • 65 citations

Experimental cutaneous candidiasis in rodents; II. Role of the stratum corneum barrier and serum complement as a mediator of a protective infalmmatory response

1978 • 56 citations

The genes encoding the secreted aspartyl proteinases of Candida albicans constitute a family with at least three members

1993 • 56 citations

Activation and binding of C3 by Candida albicans

1987 • 55 citations

Biological and Chemical Characterization of Toxic Substances from Candida albicans

1972 • 55 citations

Chemotactic factor produced by Candida albicans

1977 • 46 citations

Frequency of Candida albicans serotypes in patients with denture-induced stomatitis and in normal denture wearers.

1982 • 45 citations

On the role of proteinases from Candida albicans in the pathogenesis of acronecrosis

1983 • 44 citations

Heterogeneity of the purified extracellular aspartyl proteinase from Candida albicans: characterization with monoclonal antibodies and N-terminal amino acid sequence analysis

1993 • 42 citations

CandidaProteinases and Candidosis

1988 • 41 citations

Experimental Cutaneous Candidiasis in Rodents

1978 • 40 citations

Transcription of the Gene for a Pepsinogen, PEP1, Is Regulated by White-Opaque Switching in Candida albicans

1992 • 40 citations

Oral carriage of Candida albicans in murine AIDS

1997 • 34 citations

Activation of the interleukin-1beta precursor by Treponema denticola: a potential role in chronic inflammatory periodontal diseases

1997 • 28 citations

The in vitro proteolytic and saccharolytic activity of Candida species cultured in human saliva

1994 • 24 citations

A new, sensitive polynucleotide probe for distinguishingCandida albicansstrains and its use with a computer assisted archiving and pattern comparison system

1992 • 21 citations

Dynamic expression of cell-surface antigens probed with Candida albicans-specific monoclonal antibodies

1996 • 11 citations

Neutral proteinase activity ofCandida albicans

1986 • 5 citations