Cleavage of interleukin 1 beta (IL-1 beta) precursor to produce active IL-1 beta by a conserved extracellular cysteine protease from Streptococcus pyogenes.

Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids

1982 • 11,668 citations

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

1992 • 2,495 citations

Interleukin-1 and interleukin-1 antagonism

1991 • 2,276 citations

Molecular Cloning of the Interleukin-1β Converting Enzyme

1992 • 1,115 citations

Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of the interleukin-1β converting enzyme

1992 • 981 citations

Invasive Group A Streptococcus Infections

1992 • 710 citations

Sourcebook of bacterial protein toxins

1991 • 537 citations

Identification of a monocyte specific pre-interleukin 1 beta convertase activity.

1989 • 501 citations

A soluble receptor for interleukin-1β encoded by vaccinia virus: A novel mechanism of virus modulation of the host response to infection

1992 • 475 citations

Interleukin 1 is processed and released during apoptosis.

1991 • 459 citations

Streptococcus pyogenes causing toxic-shock-like syndrome and other invasive diseases: clonal diversity and pyrogenic exotoxin expression.

1991 • 429 citations

Virus proteins that counteract host immune defenses

1992 • 392 citations

Generation of biologically active interleukin-1 beta by proteolytic cleavage of the inactive precursor.

1988 • 377 citations

Vaccinia and cowpox viruses encode a novel secreted interleukin-1-binding protein

1992 • 315 citations

Encoding of a Homolog of the IFN-γ Receptor by Myxoma Virus

1992 • 303 citations

Aspects of Pathogenesis of Serious Group A Streptococcal Infections in Sweden, 1988-1989

1992 • 303 citations

Activation of interleukin‐ 1β by a co‐induced protease

1989 • 254 citations

The kinetics of interleukin 1 secretion from activated monocytes. Differences between interleukin 1 alpha and interleukin 1 beta.

1988 • 249 citations

Bacterial growth blocked by a synthetic peptide based on the structure of a human proteinase inhibitor

1989 • 222 citations

Human keratinocytes produce but do not process pro-interleukin-1 (IL-1) beta. Different strategies of IL-1 production and processing in monocytes and keratinocytes.

1991 • 209 citations

The major neutral proteinase of Entamoeba histolytica.

1986 • 201 citations

Parasite proteases

1989 • 197 citations

Streptococcal Toxic Shock Syndrome: Synthesis of Tumor Necrosis Factor and Interleukin-1 by Monocytes Stimulated with Pyrogenic Exotoxin A and Streptolysin O

1992 • 194 citations

Structural and functional identification of GP57/51 antigen of Trypanosoma cruzi as a cysteine proteinase

1990 • 178 citations

A Pre-aspartate-specific Protease from Human Leukocytes That Cleaves Pro-interleukin-1 β

1989 • 174 citations

Platelet-derived growth factor suppresses and fibroblast growth factor enhances cytokine-induced production of nitric oxide by cultured smooth muscle cells. Effects on cell proliferation.

1992 • 172 citations

Proteolytic inactivation of cytokines by Pseudomonas aeruginosa

1990 • 168 citations

Nucleotide sequence of the streptococcal pyrogenic exotoxin type B gene and relationship between the toxin and the streptococcal proteinase precursor

1990 • 149 citations

Thiol proteinase expression and pathogenicity of Entamoeba histolytica

1989 • 143 citations

Geographic and Temporal Distribution and Molecular Characterization of Two Highly Pathogenic Clones ofStreptococcus pyogenesExpressing Allelic Variants of Pyrogenic Exotoxin A (Scarlet Fever Toxin)

1993 • 129 citations

Molecular epidemiologic analysis of the type A streptococcal exotoxin (erythrogenic toxin) gene (speA) in clinical Streptococcus pyogenes strains

1989 • 105 citations

A simple, sensitive bioassay for the detection of interleukin-1 using human melanoma A375 cell line

1988 • 99 citations

Frequency of the erythrogenic toxin B and C genes (speB and speC) among clinical isolates of group A streptococci

1991 • 96 citations

THE CRYSTALLIZATION AND SEROLOGICAL DIFFERENTIATION OF A STREPTOCOCCAL PROTEINASE AND ITS PRECURSOR

1950 • 92 citations

Isolation and characterization of erythrogenic toxins V. Communication: Identity of erythrogenic toxin type B and Streptococcal proteinase precursor

1983 • 89 citations

Amplification and sequencing of genomic DNA fragments encoding cysteine proteases from protozoan parasites

1990 • 85 citations

A major cysteine proteinase is developmentally regulated in Trypanosoma cruzi

1990 • 73 citations

The major cysteine proteinase (cruzipain) from Trypanosoma cruzi is antigenic in human infections

1991 • 68 citations

Self-proteolysis of the cysteine proteinase, cruzipain, from Trypanosoma cruzi gives a major fragment corresponding to its carboxy-terminal domain

1991 • 47 citations

MYOCARDIAL NECROSIS PRODUCED IN ANIMALS BY MEANS OF CRYSTALLINE STREPTOCOCCAL PROTEINASE

1954 • 42 citations

Identification and partial characterization of Trypanosoma cruzi antigens recognized by T cells and immune sera from patients with Chagas' disease

1990 • 33 citations