Immunotolerance and prevention of ocular autoimmune disease

The mechanism of action of cyclosporin A and FK506

1992 • 2,127 citations

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

1994 • 1,995 citations

Immunologically Privileged Sites

1978 • 815 citations

Negative selection of lymphocytes

1994 • 810 citations

Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering.

1992 • 734 citations

Induction of anergy or active suppression following oral tolerance is determined by antigen dosage.

1994 • 643 citations

Effects of Oral Administration of Type II Collagen on Rheumatoid Arthritis

1993 • 634 citations

Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease.

1994 • 599 citations

Double-Blind Pilot Trial of Oral Tolerization with Myelin Antigens in Multiple Sclerosis

1993 • 592 citations

Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis

1989 • 588 citations

Idiotypic Networks and Other Preconceived Ideas

1984 • 543 citations

Inhibition of Experimental Drug Allergy by Prior Feeding of the Sensitizing Agent

1946 • 510 citations

The regulation of immune responses to dietary protein antigens

1987 • 489 citations

Selective Events in T Cell Development

1994 • 486 citations

Role of T‐Cell Derived Cytokines in the Downregulation of Immune Responses in Parasitic and Retroviral Infection

1992 • 473 citations

Uveitis: Fundamentals and Clinical Practice

1990 • 467 citations

Antigen-driven bystander suppression after oral administration of antigens.

1991 • 438 citations

Small B cells as antigen-presenting cells in the induction of tolerance to soluble protein antigens.

1992 • 435 citations

Anti-Idiotypic Network Induced by T Cell Vaccination Against Experimental Autoimmune Encephalomyelitis

1988 • 409 citations

Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein and its fragments.

1988 • 404 citations

Suppression of type II collagen-induced arthritis by intragastric administration of soluble type II collagen.

1986 • 357 citations

Both rat and mouse T cell receptors specific for the encephalitogenic determinant of myelin basic protein use similar V alpha and V beta chain genes even though the major histocompatibility complex and encephalitogenic determinants being recognized are different.

1989 • 321 citations

Suppression of experimental autoimmune encephalomyelitis by the oral administration of myelin basic protein

1988 • 291 citations

Inhibition of S-antigen induced experimental autoimmune uveoretinitis by oral induction of tolerance with S-antigen.

1990 • 288 citations

Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein. II. Suppression of disease and in vitro immune responses is mediated by antigen-specific CD8+ T lymphocytes.

1989 • 284 citations

Induction of anterior chamber-associated immune deviation requires an intact, functional spleen.

1981 • 255 citations

Studies on the induction of anterior chamber‐associated immune deviation (ACAID) III. Induction of ACAID depends upon intraocular transforming growth factor‐β

1992 • 250 citations

Direct evidence for anergy in T lymphocytes tolerized by oral administration of ovalbumin

1993 • 233 citations

Immune regulation and the eye: a dangerous compromise

1987 • 217 citations

Immune response to immunization via the anterior chamber of the eye. I. F. lymphocyte-induced immune deviation.

1977 • 208 citations

Fluids from immune privileged sites endow macrophages with the capacity to induce antigen‐specific immune deviation via a mechanism involving transforming growth factor‐β

1992 • 206 citations

Oral tolerance in experimental autoimmune uveoretinitis. Distinct mechanisms of resistance are induced by low dose vs high dose feeding protocols.

1993 • 184 citations

Experimental allergic encephalomyelitis in the absence of a classical delayed-type hypersensitivity reaction. Severe paralytic disease correlates with the presence of interleukin 2 receptor-positive cells infiltrating the central nervous system.

1987 • 182 citations

Cyclosporin a. Inhibition of experimental autoimmune uveitis in Lewis rats.

1981 • 171 citations

The Biological Reactions of the Vegetable Proteins I. Anaphylaxis

1911 • 158 citations

Neonatal Thymectomy Results in a Repertoire Enriched in T Cells Deleted in Adult Thymus

1989 • 146 citations

Immunology of the intestinal tract

1993 • 142 citations

Immune Response to Immunization Via the Anterior Chamber of the Eye

1977 • 139 citations

ORAL, BUT NOT INTRAVENOUS, ALLOANTIGEN PREVENTS ACCELERATED ALLOGRAFT REJECTION BY SELECTIVE INTRAGRAFT TH2 CELL ACTIVATION

1993 • 124 citations

Organ-Resident, Nonlymphoid Cells Suppress Proliferation of Autoimmune T-Helper Lymphocytes

1987 • 118 citations

Glial retinal Müller cells produce IL-1 activity and have a dual effect on autoimmune T helper lymphocytes. Antigen presentation manifested after removal of suppressive activity.

1988 • 116 citations

Orally administered myelin basic protein in neonates primes for immune responses and enhances experimental autoimmune encephalomyelitis in adult animals

1994 • 114 citations

Interleukin-2 treatment potentiates induction of oral tolerance in a murine model of autoimmunity.

1994 • 112 citations

Uveitis. Fundamentals and Clinical Practice

1989 • 106 citations

Modulation of Experimental Autoimmune Uveitis With Cyclosporin A

1982 • 95 citations

Immune response to immunization via the anterior chamber of the eye. II. An analysis of F1 lymphocyte-induced immune deviation.

1978 • 93 citations

Retinal Pigment Epithelial Cells Modulate Lymphocyte Function at the Blood-Retina Barrier by Autocrine PGE2 and Membrane-Bound Mechanisms

1993 • 92 citations

Suppression of experimental autoimmune uveitis in mice by induction of anterior chamber-associated immune deviation with interphotoreceptor retinoid-binding protein.

1992 • 90 citations

Recruitment of antigen-nonspecific cells plays a pivotal role in the pathogenesis of a T cell-mediated organ-specific autoimmune uveoretinitis

1993 • 80 citations

Analysis of an in vitro-generated signal that induces systemic immune deviation similar to that elicited by antigen injected into the anterior chamber of the eye

1992 • 77 citations

Transplantation immunology of the anterior chamber of the eye. II. Immune response to allogeneic cells.

1975 • 74 citations

Parameters of tolerance induction by antigen targeted to B lymphocytes.

1993 • 73 citations

Immune Response to Immunization via the Anterior Chamber of the Eye

1978 • 63 citations

Synergistic effect of rapamycin and cyclosporin A in the treatment of experimental autoimmune uveoretinitis.

1995 • 63 citations

Remarks on a Cutaneous Affection, prodused by cretain Poisonous Vagetables

1829 • 63 citations

Characterization of a new, potent, immunopathogenic epitope in S-antigen that elicits T cells expressing V beta 8 and V alpha 2-like genes.

1991 • 63 citations

Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein. V. Hierarchy of suppression by myelin basic protein from different species

1992 • 63 citations

Treatment of autoimmune uveoretinitis in the rat with rapamycin, an inhibitor of lymphocyte growth factor signal transduction

1993 • 57 citations

T-cell tolerance

1993 • 55 citations

Analysis of an in vitro-generated signal that induces systemic immune deviation similar to that elicited by antigen injected into the anterior chamber of the eye.

1992 • 55 citations

Rapamycin Inhibits p34^cdc2 Expression and Arrests T Lymphocyte Proliferation at the G1/S Transition

1993 • 46 citations

Transplant Rejection

1993 • 42 citations

Transplantation Immunology of the Anterior Chamber of the Eye

1975 • 40 citations

The Intestinal Immune System and Its Relation to Disease

1993 • 38 citations

Evidence for selective accumulation of V beta 8+ T lymphocytes in experimental autoimmune uveoretinitis induced with two different retinal antigens.

1993 • 38 citations

Conserved T cell receptor V gene usage by uveitogenic T cells

1991 • 37 citations

Modification of the Immune Response by Oral Tolerance: Antigen Requirements and Interaction with Immunogenic Stimuli

1993 • 35 citations

INHIBITION OF EXPERIMENTAL AUTOIMMUNE UVEITIS IN LEWIS RATS

1981 • 33 citations

FK506 treatment of S-antigen induced uveitis in primates

1991 • 30 citations

Antigen processing in the mucosal immune system.

1992 • 30 citations

Cyclosporine-induced specific unresponsiveness to retinal soluble antigen in experimental autoimmune uveoretinitis

1988 • 29 citations

Anergy of antigen-specific T lymphocytes is a potent mechanism of intravenously induced tolerance.

1994 • 29 citations

Glial cells as suppressor cells: Characterization of the inhibitory function

1989 • 28 citations

Effects of cyclosporine in spontaneous, posterior uveitis

1986 • 27 citations

Rapamycin-induced long-term allograft survival depends on persistence of alloantigen.

1994 • 27 citations

Transplantation immunology of the anterior chamber of the eye. I. An intra-ocular graft-vs-host reaction (immunogenic anterior uveitis).

1975 • 26 citations

Spontaneous development of autoimmune uveoretinitis in nude mice following reconstitution with embryonic rat thymus

1991 • 26 citations

Control of experimental autoimmune uveoretinitis by low dose T cell vaccination

1992 • 25 citations

The Promise of Asexual Malaria Vaccine Development

1994 • 25 citations

Antigen-specific suppressor cells induced by FK506 in experimental autoimmune uveoretinitis in the rat.

1990 • 22 citations

Transplantation Immunology of the Anterior Chamber of the Eye

1975 • 21 citations

Trials of vaccination against experimental autoimmune uveoretinitis with a T-cell receptor peptide

1991 • 20 citations

Predominant usage of Vβ8.3 T cell receptor in a T cell line that induces experimental autoimmune uveoretinitis (EAU)

1992 • 19 citations

Uveitis and immune responses in primates immunized with IRBP-derived synthetic peptides

1990 • 18 citations

Antigen-directed retention of an autoimmune T-cell line

1987 • 18 citations

The immune system of the gastrointestinal tract

1993 • 17 citations

Intraocular trafficking of lymphocytes in locally induced experimental autoimmune uveoretinitis (EAU)

1988 • 16 citations

Prolonged survival without posttransplant immunosuppression in a large animal model.

1994 • 15 citations

Thymic selection

1992 • 15 citations

T cell receptor β-chain usage in experimental autoimmune uveoretinitis

1991 • 13 citations

Mucosal immunization via M cells for production of protective secretory IgA antibodies.

1994 • 12 citations

Mucosal microenvironment and mucosal response.

1994 • 12 citations

Experimental autoimmune uveoretinitis: idiotypic regulation and disease suppression

1990 • 9 citations

Regulation of retinal autoimmunity via the idiotypic network

1990 • 9 citations

Modulation of experimental autoimmune uveoretinitis by adoptive transfer of cells from rats immunized with anti-S-antigen monoclonal antibody.

1989 • 8 citations

Effects of cyclosporin on autoimmune diabetes induced in mice by streptozotocin: beta cell-toxicity and rebound of insulitis after cessation of treatment.

1988 • 8 citations

Incomplete activation of lymphokine-producing T cells by alloantigenic intraocular tumours in anterior chamber-associated immune deviation.

1993 • 8 citations

[Immunologic suppression of experimental autoimmune uveitis].

1991 • 8 citations

ANTI-CD2 MONOCLONAL ANTIBODIES SYNERGIZE WITH FK506 BUT NOT WITH CYCLOSPORINE OR RAPAMYCIN TO INDUCE TOLERANCE

1994 • 7 citations

Immune Responses against Self-TCR Peptides

1994 • 6 citations

Oral immunization with allogeneic splenocytes inhibits development of accelerated but not acute rejection of cardiac grafts: analysis of intragraft effector mechanisms.

1992 • 5 citations

Delayed-type hypersensitivity response in experimental autoimmune neuritis treated with peptide-coupled spleen cells

1994 • 5 citations

Suppression of hen egg lysozyme-induced arthritis by intravenous antigen administration: no role in this for antigen-driven bystander suppression

1994 • 4 citations

CYCLOSPORINE-INDUCED IMMUNE UNRESPONSIVENESS IN DOGS WITH INTRASPLENIC ISLET ALLOGRAFTS

1991 • 2 citations

[Active immune regulation by cells of the ciliary body].

1991 • 2 citations