The immune system of the gastrointestinal tract

A Cell Culture Model for T Lymphocyte Clonal Anergy

1990 • 1,894 citations

The Basis for the Immunoregulatory Role of Macrophages and Other Accessory Cells

1987 • 1,040 citations

Immunoglobulin A (IgA): Molecular and Cellular Interactions Involved in IgA Biosynthesis and Immune Response

1987 • 956 citations

The common mucosal immune system and current strategies for induction of immune responses in external secretions

1987 • 810 citations

Lymphocyte interactions with endothelial cells

1992 • 689 citations

Immunobiology and immunopathology of human gut mucosa: Humoral immunity and intraepithelial lymphocytes

1989 • 552 citations

Human lymphocytes bearing T cell receptor gamma/delta are phenotypically diverse and evenly distributed throughout the lymphoid system.

1989 • 547 citations

A monoclonal antibody (HML‐1) defining a novel membrane molecule present on human intestinal lymphocytes

1987 • 461 citations

Enhanced production of interleukin 1-beta by mononuclear cells isolated from mucosa with active ulcerative colitis of Crohn's disease.

1989 • 430 citations

The V beta repertoire of mouse gut homodimeric alpha CD8+ intraepithelial T cell receptor alpha/beta + lymphocytes reveals a major extrathymic pathway of T cell differentiation.

1991 • 345 citations

Carbohydrate ligands of the LEC cell adhesion molecules

1990 • 338 citations

A large fraction of human peripheral blood gamma/delta + T cells is activated by Mycobacterium tuberculosis but not by its 65-kD heat shock protein.

1990 • 331 citations

Roles of Adhesion Molecules in T‐Cell Recognition: Fundamental Similarities between Four Integrins on Resting Human T Cells (LFA‐1, VLA‐4, VLA‐5, VLA‐6) in Expression, Binding, and Costimulation

1990 • 322 citations

Role of J Chain and Secretory Component in Receptor‐Mediated Glandular and Hepatic Transport of Immunoglobulins in Man

1985 • 312 citations

Intraepithelial T Cells of the TcRγ/δ⁺CD8⁻ and Vδ1/Jδ1⁺ Phenotypes are Increased in Coeliac Disease

1989 • 311 citations

THE IgA1 PROTEASES OF PATHOGENIC BACTERIA

1983 • 290 citations

Antigen presentation by epithelial cells of the rat small intestine. I. Kinetics, antigen specificity and blocking by anti-Ia antisera.

1986 • 289 citations

The Regulation of Lymphocyte Traffic

1986 • 285 citations

MHC class II antigen-bearing dendritic cells in pulmonary tissues of the rat. Regulation of antigen presentation activity by endogenous macrophage populations.

1988 • 285 citations

Regulation of IgA synthesis and immune response by T cells and interleukins

1989 • 278 citations

Intestinal lymphocyte subpopulations in inflammatory bowel disease: an analysis by immunohistological and cell isolation techniques.

1984 • 273 citations

Subsets of CD3⁺ (T cell receptor α/β or γ/δ) and CD3⁻ lymphocytes isolated from normal human gut epithelium display phenotypical features different from their counterparts in peripheral blood

1990 • 269 citations

Homing Receptors and the Control of Lymphocyte Migration

1986 • 265 citations

Antigen presentation by epithelial cells of the rat small intestine. II. Selective induction of suppressor T cells.

1986 • 252 citations

Different subclass distribution of IgA-producing cells in human lymphoid organs and various secretory tissues.

1986 • 252 citations

Expression of disulfide‐linked and non‐disulfide‐linked forms of the T cell receptor γ/δ heterodimer in human intestinal intraepithelial lymphocytes

1989 • 248 citations

Recognition of heat shock proteins and γΔ cell function

1990 • 247 citations

A family of beta 7 integrins on human mucosal lymphocytes.

1992 • 227 citations

Expression of leukocyte adhesion molecules by mucosal mononuclear phagocytes in inflammatory bowel disease

1991 • 197 citations

Activation of peripheral blood and intestinal lamina propria lymphocytes in Crohn's disease. In vivo state of activation and in vitro response to stimulation as defined by the expression of early activation antigens.

1987 • 182 citations

Novel function for intestinal intraepithelial lymphocytes. Murine CD3+, gamma/delta TCR+ T cells produce IFN-gamma and IL-5.

1991 • 175 citations

The effect of antigen deprivation on thymus-dependent and thymus-independent lymphocytes in the small intestine of the mouse.

1972 • 174 citations

Lymphocyte subpopulations in the human small intestine. The findings in normal mucosa and in the mucosa of patients with adult coeliac disease.

1983 • 169 citations

Oligoclonality of human intestinal intraepithelial T cells.

1992 • 165 citations

Differential expression of CD25 (interleukin-2 receptor) on lamina propria T cells and macrophages in the intestinal lesions in Crohn's disease and ulcerative colitis.

1990 • 158 citations

Regulation of the Immune Response — Role of the Macrophage

1980 • 158 citations

Intraepithelial lymphocytes of human gut: isolation, characterisation and study of natural killer activity.

1985 • 150 citations

Human IgG subclasses in health and disease (A review)Part I

1980 • 146 citations

Immunohistological characterization of intraepithelial and lamina propria lymphocytes in control ileum and colon and in inflammatory bowel disease

1986 • 143 citations

Human Immunoglobulin G and Immunoglobulin G Subclasses: Biochemical, Genetic, and Clinical Aspects

1989 • 140 citations

The clinical condition of IgA-deficient patients is related to the proportion of IgD- and IgM-producing cells in their nasal mucosa.

1987 • 131 citations

Heterogeneity of HLA-DR-positive histiocytes in human intestinal lamina propria: a combined histochemical and immunohistological analysis.

1983 • 130 citations

Immunoglobulin A subclass distribution of naturally occurring salivary antibodies to microbial antigens

1985 • 120 citations

Extrathymic differentiation of intraepithelial lymphocytes: generation of a separate and unequal T-cell repertoire?

1991 • 114 citations

Orally inducible immune unresponsiveness is abrogated by IFN-gamma treatment.

1990 • 113 citations

Immunological suppression by human CD8+ T cells is receptor dependent and HLA-DQ restricted.

1991 • 103 citations

Integrin Molecules Involved in Lymphocyte Homing to Peyer's Patches

1989 • 98 citations

Antigen-induced suppression of the proliferative response of T cell clones.

1988 • 96 citations

Immunoelectron microscopic localization of HLA-DR antigen in control small intestine and colon and in inflammatory bowel disease

1986 • 95 citations

Epithelial Expression of HLA, Secretory Component (Poly‐Ig Receptor), and Adhesion Molecules in the Human Alimentary Tracta

1992 • 91 citations

Regulatory function for murine intraepithelial lymphocytes. Two subsets of CD3+, T cell receptor-1+ intraepithelial lymphocyte T cells abrogate oral tolerance.

1990 • 90 citations

T cell subclasses in fetal human ileum.

1986 • 87 citations

Significance of different J chain profiles in human tissues: generation of IgA and IgM with binding site for secretory component is related to the J chain expressing capacity of the total local immunocyte population, including IgG and IgD producing cells, and depends on the clinical state of the tissue.

1984 • 85 citations

Memory CD4+ T cells in man form two distinct subpopulations, defined by their expression of isoforms of the leucocyte common antigen, CD45.

1990 • 80 citations

T Lymphocytes in Human Gut Epithelium Preferentially Express the α/β Antigen Receptor and are often CD45/UCHL1‐Positive

1989 • 78 citations

The polymeric immunoglobulin receptor. A model protein to study transcytosis.

1991 • 77 citations

Spontaneous cytotoxicity of human intraepithelial lymphocytes against epithelial cell tumors

1992 • 77 citations

The human transmembrane secretory component (poly-Ig receptor): molecular cloning, restriction fragment length polymorphism and chromosomal sublocalization

1991 • 75 citations

Expression of Major Histocompatibility Complex Class II Subregion Products by Jejunal Epithelium in Patients with Coeliac Disease

1987 • 74 citations

HML-1 antigen on mucosa-associated T cells, activated cells, and hairy leukemic cells is a new integrin containing the beta 7 subunit.

1991 • 71 citations

Immunohistochemical Characterisation of Macrophages in Human Liver and Gastrointestinal Tract: Expression of CD4, HLA-DR, OKM1, and the Mature Macrophage Marker 25F9 in Normal and Diseased Tissue

1987 • 70 citations

Intra-epithelial lymphocytes: interferon-gamma production and suppressor/cytotoxic activities

1990 • 68 citations

Relation between HLA-DR-like antigens and secretory component (SC) in jejunal epithelium of patients with coeliac disease or dermatitis herpetiformis.

1981 • 68 citations

Human CD8⁺ intraepithelial T lymphocytes are mainly CD45RA⁻RB⁺ and show increased co‐expression of CD45R0 in celiac disease

1990 • 66 citations

Expression of T cell receptors TcR1 (gamma/delta) and TcR2 (alpha/beta) in the human intestinal mucosa

1990 • 64 citations

The role of activated T lymphocytes in gastrointestinal disease

1990 • 64 citations

Immunomorphological Characteristics of Human Peyer’s Patches

1990 • 63 citations

Immunology of the gastrointestinal tract

1987 • 59 citations

Alveolar macrophage suppression of canine bronchoalveolar lymphocytes: the role of prostaglandin E2 in the inhibition of mitogen-responses.

1980 • 58 citations

CD4 positive Leu-8 negative helper-inducer T cells predominate in the human intestinal lamina propria.

1988 • 57 citations

The microenvironment of coeliac disease: T cell phenotypes and expression of the T2 'T blast' antigen by small bowel lymphocytes.

1985 • 56 citations

Differential upregulation of intercellular adhesion molecule-1 in coeliac disease

1990 • 55 citations

Heterogeneity of non-lymphoid cells expressing HLA-D region antigens in human fetal gut.

1987 • 55 citations

Regulation of IgA secretion by T cell clones derived from the human gastrointestinal tract.

1988 • 53 citations

Selective death of T cell receptor γ/δ⁺ intraepithelial lymphocytes by apoptosis

1990 • 47 citations

Immunoregulatory function of CD3+, CD4-, and CD8- T cells. Gamma delta T cell receptor-positive T cells from nude mice abrogate oral tolerance.

1989 • 45 citations

The proliferative response of cloned Peyer's patch switch T cells to syngeneic and allogeneic stimuli.

1985 • 43 citations

Terminally Differentiated Human Intestinal B Cells

1990 • 43 citations

Immunoperoxidase demonstration of the cellular composition of the normal and coeliac small bowel.

1987 • 40 citations

Studies of intestinal lymphoid tissue. II. Aspects of proliferation and migration of epithelial lymphocytes in the small intestine of mice.

1975 • 38 citations

Identity between the novel integrin β7 subunit and an antigen found highly expressed on intraepithelial lymphocytes in the small intestine

1991 • 37 citations

T lymphocytes of the human colonic mucosa: functional and phenotypic analysis.

1988 • 36 citations

Differential expression of HLA‐D gene products in the normal and coeliac small bowel

1988 • 31 citations

Isotype distribution of mucosal IgG-producing cells in patients with various IgG subclass deficiencies

1991 • 27 citations

T Cell and Mononuclear Phagocyte Populations of the Human Small and Large Intestine

1987 • 25 citations

Human colonic intra-epithelial lymphocytes are suppressor cells

1991 • 20 citations

Cellular and molecular events accompanying IgA B cell differentiation.

1988 • 14 citations

Lymphocyte and endothelial cell recognition elements that control lymphocyte traffic to mucosa-associated lymphatic tissues.

1988 • 13 citations

Expression of CD6 and the UCHL1-defined CD45 (p180) antigen by human colonic T lymphocytes.

1989 • 13 citations

The role of lymphokines and cytokines in mucosal immune function

1991 • 8 citations

A novel mechanism for the selection of isotype-specific antibody responses: the role of intestinal T cells in the regulation of IgA synthesis by the anti-suppressor circuit.

1988 • 7 citations

Respiratory burst capacity of human intestinal macrophage subpopulations

1990 • 7 citations

Contrasuppression and the control of microenvironmental immune responses.

1988 • 4 citations

The CD4 Leu 8- T helper cell in colonic mucosa: a quantitative and functional analysis.

1989 • 3 citations