Ghrelin regulates mitochondrial-lipid metabolism gene expression and tissue fat distribution in liver and skeletal muscle

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

1999 • 8,261 citations

Nonalcoholic Fatty Liver Disease

2002 • 5,091 citations

Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

2002 • 4,335 citations

Ghrelin induces adiposity in rodents

2000 • 3,915 citations

A role for ghrelin in the central regulation of feeding

2001 • 3,415 citations

Cellular mechanisms of insulin resistance

2000 • 2,692 citations

Mitochondrial Dysfunction in the Elderly: Possible Role in Insulin Resistance

2003 • 2,035 citations

Circulating Ghrelin Levels Are Decreased in Human Obesity

2001 • 1,999 citations

Role of Fatty Acids in the Pathogenesis of Insulin Resistance and NIDDM

1997 • 1,611 citations

Ghrelin Causes Hyperphagia and Obesity in Rats

2001 • 1,121 citations

Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss

1999 • 1,052 citations

Muscle fiber type composition of the rat hindlimb

1984 • 1,012 citations

AMP-activated protein kinase, a metabolic master switch: possible roles in Type 2 diabetes

1999 • 1,009 citations

Ghrelin Strongly Stimulates Growth Hormone Release in Humans

2000 • 835 citations

Direct antidiabetic effect of leptin through triglyceride depletion of tissues

1997 • 664 citations

Chronic Central Infusion of Ghrelin Increases Hypothalamic Neuropeptide Y and Agouti-Related Protein mRNA Levels and Body Weight in Rats

2001 • 617 citations

Treatment of insulin resistance with peroxisome proliferator–activated receptor γ agonists

2000 • 535 citations

Skeletal Muscle Lipid Content and Oxidative Enzyme Activity in Relation to Muscle Fiber Type in Type 2 Diabetes and Obesity

2001 • 506 citations

Intramuscular lipid content is increased in obesity and decreased by weight loss

2000 • 505 citations

Muscle-specific Pparg deletion causes insulin resistance

2003 • 487 citations

Chronic intracerebroventricular neuropeptide-Y administration to normal rats mimics hormonal and metabolic changes of obesity.

1993 • 466 citations

Obesity Induces Expression of Uncoupling Protein-2 in Hepatocytes and Promotes Liver ATP Depletion

1999 • 442 citations

Uncoupling proteins 2 and 3: potential regulators of mitochondrial energy metabolism.

2000 • 423 citations

Ghrelin and Des-Octanoyl Ghrelin Promote Adipogenesis Directly in Vivo by a Mechanism Independent of the Type 1a Growth Hormone Secretagogue Receptor

2003 • 417 citations

Muscle-specific PPARγ-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones

2003 • 410 citations

Effects of Aging on Mitochondrial DNA Copy Number and Cytochromec Oxidase Gene Expression in Rat Skeletal Muscle, Liver, and Heart

2000 • 367 citations

Ghrelin Modulates the Downstream Molecules of Insulin Signaling in Hepatoma Cells

2002 • 292 citations

Relation of triglyceride stores in skeletal muscle cells to central obesity and insulin sensitivity in European and South Asian men

1999 • 240 citations

The Role of Ghrelin and Growth Hormone Secretagogues Receptor on Rat Adipogenesis

2003 • 233 citations

Poststarvation hyperphagia and body fat overshooting in humans: a role for feedback signals from lean and fat tissues

1997 • 184 citations

Effects of caloric restriction on mitochondrial function and gene transcripts in rat muscle

2002 • 170 citations

Loss of Meal-Induced Decrease in Plasma Ghrelin Levels in Patients with Anorexia Nervosa

2003 • 165 citations

Effects of Insulin Treatment in Type 2 Diabetic Patients on Intracellular Lipid Content in Liver and Skeletal Muscle

2002 • 165 citations

REGULATION OF FATTY ACID OXIDATION IN SKELETAL MUSCLE

1999 • 140 citations

Induction and reversibility of an obesity syndrome by intracerebroventricular neuropeptide Y administration to normal rats

1994 • 127 citations

Hyperleptinemia prevents increased plasma ghrelin concentration during short-term moderate caloric restriction in rats

2003 • 126 citations

Hormonal regulation of fatty acid synthetase, acetyl-CoA carboxylase and fatty acid synthesis in mammalian adipose tissue and liver

1975 • 122 citations

Modulation of pulsatile GH release through a novel receptor in hypothalamus and pituitary gland.

1996 • 120 citations

Glucocorticoid Hormone Stimulates Mitochondrial Biogenesis Specifically in Skeletal Muscle

2002 • 106 citations

Transcriptional Regulation of the Mouse Uncoupling Protein-2 Gene

2001 • 105 citations

Alterations in the rate of lipogenesis in vivo in maternal liver and adipose tissue on premature weaning of lactating rats: a possible regulatory role of prolactin

1979 • 97 citations

T₃ increases mitochondrial ATP production in oxidative muscle despite increased expression of UCP2 and -3

2001 • 92 citations

Expression of Genes Involved in Lipid Metabolism Correlate with Peroxisome Proliferator-Activated Receptor γ Expression in Human Skeletal Muscle¹

2000 • 90 citations

Identification of a biochemical link between energy intake and energy expenditure

2002 • 79 citations

Fatty liver produced by dietary deficiencies: its pathogenesis and potentiation by ethanol

1969 • 76 citations

Identification of a biochemical link between energy intake and energy expenditure

2002 • 68 citations

Insulin resistance and mitochondrial abnormalities in NASH: A cool look into a burning issue

2001 • 66 citations

Impaired expression of NADH dehydrogenase subunit 1 and PPARγ coactivator-1 in skeletal muscle of ZDF rats

2004 • 64 citations

Changes in uncoupling protein-2 and -3 expression in aging rat skeletal muscle, liver, and heart

2001 • 63 citations

In vitro effects of glucocorticoid on mitochondrial energy metabolism

1991 • 54 citations

Gastric surgery is not a risk for Barrett's esophagus or esophageal adenocarcinoma

2001 • 51 citations

Effects of corticosterone on muscle mitochondria identifying different sensitivity to glucocorticoids in Lewis and Fischer rats

2004 • 50 citations

Increased susceptibility to fatigue of slow- and fast-twitch muscles from mice lacking the MG29 gene

2000 • 45 citations

Skeletal muscle heterogeneity in fasting-induced upregulation of genes encoding UCP2, UCP3, PPARγ and key enzymes of lipid oxidation

2002 • 45 citations

Expression of Genes Involved in Lipid Metabolism Correlate with Peroxisome Proliferator-Activated Receptor Expression in Human Skeletal Muscle

2000 • 41 citations

Genomic Structure, Expression, and Chromosomal Localization of the Human Glycine N-Methyltransferase Gene

2000 • 40 citations

Mitochondrial energy metabolism in a model of undernutrition induced by dexamethasone

2003 • 38 citations

Refeeding, metabolic rate, and weight gain in anorexia nervosa: A review

1995 • 35 citations

Mitochondria: DNA proteins and disease

1994 • 29 citations

Energy intake-independent modulation of triglyceride metabolism by glucocorticoids in the rat

2000 • 17 citations

Hyperleptinemia Prevents Increased Plasma Ghrelin Concentration during Short-term Moderate Caloric Restriction in Rats. Gastroenterology

2003 • 15 citations

Brief food restriction increases FA oxidation and glycogen synthesis under insulin-stimulated conditions

2002 • 9 citations

Some effects of medroxyprogesterone acetate on intermediary metabolism in rat liver

1978 • 5 citations