Modulator inhibits nuclear translocation of the glucocorticoid receptor and inhibits glucocorticoid-induced apoptosis in the human leukemic cell line CEM C-7.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

G ₁ Events and Regulation of Cell Proliferation

1989 • 2,203 citations

Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death.

1984 • 1,441 citations

Apoptosis: The Biochemistry and Molecular Biology of Programmed Cell Death*

1993 • 1,005 citations

[11] DNA-cellulose chromatography

1971 • 842 citations

Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA

1993 • 758 citations

Toward an understanding of the molecular mechanisms of physiological cell death.

1993 • 623 citations

Oncogenic activity of the c-Myc protein requires dimerization with Max

1993 • 543 citations

Transcription factor access is mediated by accurately positioned nucleosomes on the mouse mammary tumor virus promoter.

1991 • 372 citations

Association of a 59-kilodalton immunophilin with the glucocorticoid receptor complex

1992 • 307 citations

Oncogenes and cell death

1994 • 266 citations

A 59-kilodalton protein associated with progestin, estrogen, androgen, and glucocorticoid receptors

1986 • 261 citations

Chromatin Structure and Transcription

1992 • 259 citations

Molybdate-stabilized nonactivated glucocorticoid-receptor complexes contain a 90-kDa non-steroid-binding phosphoprotein that is lost on activation.

1986 • 233 citations

Activation of the glucocorticoid-receptor complex

1982 • 224 citations

Rapidin VivoEffects of Glucocorticoids on the Integrity of Rat Lymphocyte Genomic Deoxyribonucleic Acid*

1986 • 218 citations

Glucocorticoids are required for establishment and maintenance of an alteration in chromatin structure: induction leads to a reversible disruption of nucleosomes over an enhancer.

1991 • 206 citations

Involvement of BCL-2 in glucocorticoid-induced apoptosis of human pre-B-leukemias.

1992 • 188 citations

Hormone-free mouse glucocorticoid receptors overexpressed in Chinese hamster ovary cells are localized to the nucleus and are associated with both hsp70 and hsp90

1990 • 187 citations

Nucleosome displacement in transcription

1993 • 179 citations

Domains of the Glucocorticoid Receptor Involved in Specific and Nonspecific Deoxyribonucleic Acid Binding, Hormone Activation, and Transcriptional Enhancement

1987 • 174 citations

The Hsp56 component of steroid receptor complexes binds to immobilized FK506 and shows homology to FKBP-12 and FKBP-13.

1992 • 170 citations

Direct evidence that the glucocorticoid receptor binds to hsp90 at or near the termination of receptor translation in vitro

1989 • 140 citations

Activation of internucleosomal DNA cleavage in human CEM lymphocytes by glucocorticoid and novobiocin. Evidence for a non-Ca2(+)-requiring mechanism(s).

1990 • 134 citations

Suppression of c-myc is a critical step in glucocorticoid-induced human leukemic cell lysis.

1993 • 125 citations

Evidence for intracellular association of the glucocorticoid receptor with the 90-kDa heat shock protein.

1988 • 124 citations

Isoform composition and stoichiometry of the approximately 90-kDa heat shock protein associated with glucocorticoid receptors.

1988 • 114 citations

Transcriptional transactivation functions localized to the glucocorticoid receptor N terminus are necessary for steroid induction of lymphocyte apoptosis.

1992 • 106 citations

Glucocorticoid Effect on Oncogene/Growth Gene Expression in Human T Lymphoblastic Leukemic Cell Line CCRF-CEM

1989 • 101 citations

Control of steroid receptor function and cytoplasmic‐nuclear transport by heat shock proteins

1992 • 100 citations

Glucocorticoid receptors lacking hormone-binding activity are bound in nuclei of ATP-depleted cells

1986 • 95 citations

Glucocorticoid-induced Lymphocytolysis Is Not Mediated by an Induced Endonuclease

1989 • 94 citations

Heat shock induces translocation to the nucleus of the unliganded glucocorticoid receptor.

1992 • 89 citations

v-mosOncoproteins Affect the Nuclear Retention and Reutilization of Glucocorticoid Receptors

1989 • 85 citations

Protein components of the nonactivated glucocorticoid receptor.

1991 • 83 citations

Direct stoichiometric evidence that the untransformed Mr 300,000, 9S, glucocorticoid receptor is a core unit derived from a larger heteromeric complex

1990 • 78 citations

Demonstration of nuclear translocation of the mineralocorticoid receptor (MR) using an anti-MR antibody and confocal laser scanning microscopy.

1993 • 77 citations

Interaction of the glucocorticoid receptor with the Mr 90,000 heat shock protein: an evolving model of ligand-mediated receptor transformation and translocation.

1989 • 74 citations

Purification and structural analysis of the modulator of the glucocorticoid-receptor complex. Evidence that modulator is a novel phosphoglyceride.

1988 • 60 citations

Thermal activation of the purified rat hepatic glucocorticoid receptor. Evidence for a two-step mechanism.

1985 • 57 citations

Region-Specific Antiglucocorticoid Receptor Antibodies Selectively Recognize the Activated Form of the Ligand-Occupied Receptor and Inhibit the Binding of Activated Complexes to Deoxyribonucleic Acid

1989 • 57 citations

Molybdate increases intracellular 3‘,5‘-guanosine cyclic monophosphate and stabilizes vitamin D receptor association with tubulin-containing filaments.

1992 • 55 citations

Steroid receptor folding by heat-shock proteins and composition of the receptor heterocomplex

1992 • 51 citations

Chromatin changes during the cell cycle

1992 • 49 citations

Recycling and Desensitization of Glucocorticoid Receptors in v-mosTransformed Cells Depend on the Ability of Nuclear Receptors to Modulate Gene Expression

1990 • 42 citations

Evidence that the modulator of the glucocorticoid-receptor complex is the endogenous molybdate factor.

1988 • 40 citations

The Mr approximately 90,000 heat shock protein: an important modulator of ligand and DNA-binding properties of the glucocorticoid receptor.

1989 • 34 citations

The glucocorticoid receptor and its endogenous regulators.

1990 • 31 citations

The structure of glucocorticoid receptors

1993 • 30 citations

Purification and characterization of two novel phosphoglycerides that modulate the glucocorticoid-receptor complex. Evidence for two modulator binding sites in the occupied/unactivated steroid hormone receptor.

1990 • 28 citations

Heat shock protein 70 is associated in substoichiometric amounts with the rat hepatic glucocorticoid receptor

1993 • 26 citations

Modulators of the glucocorticoid receptor also regulate mineralocorticoid receptor function

1992 • 19 citations

Interactions of the phenylpyrazolo steroid cortivazol with glucocorticoid receptors in steroid-sensitive and -resistant human leukemic cells.

1989 • 14 citations

Assembly of Glucocorticoid Receptor and c-JUN Homodimer on the Promoter of Mouse Mammary Tumor Virus-Long Terminal Repeat Is Influenced by Order of Addition

1993 • 13 citations

Mutational analysis of the mouse glucocorticoid receptor.

1989 • 13 citations

Modulator: the missing link

1990 • 12 citations

Glucocorticoid receptor monoclonal antibodies define the biological action of RU 38486 in intact B16 melanoma cells.

1990 • 11 citations

Endogenous modulators of glucocorticoid receptor function also regulate purified protein kinase C.

1991 • 8 citations

Specific Regulation of Male Rat Liver Cytosolic Estrogen Receptor by the Modulator of the Glucocorticoid Receptor

1993 • 4 citations