Bcr-Abl with an SH3 Deletion Retains the Ability To Induce a Myeloproliferative Disease in Mice, yet c-Abl Activated by an SH3 Deletion Induces Only Lymphoid Malignancy

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1989 • 7,496 citations

Production of high-titer helper-free retroviruses by transient transfection.

1993 • 2,280 citations

Induction of Chronic Myelogenous Leukemia in Mice by the P210 ^bcr/abl Gene of the Philadelphia Chromosome

1990 • 2,207 citations

Chronic Myeloid Leukemia

1999 • 1,639 citations

Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow.

1991 • 1,622 citations

Efficient and Rapid Induction of a Chronic Myelogenous Leukemia-Like Myeloproliferative Disease in Mice Receiving P210 bcr/abl-Transduced Bone Marrow

1998 • 756 citations

The diversity of BCR-ABL fusion proteins and their relationship to leukemia phenotype [editorial; comment]

1996 • 739 citations

Acute leukaemia in bcr/abl transgenic mice

1990 • 701 citations

BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein

1993 • 667 citations

Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway

1997 • 591 citations

Induction of a chronic myelogenous leukemia-like syndrome in mice with v-abl and BCR/ABL.

1990 • 535 citations

Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl.

1996 • 501 citations

P210 and P190 Induce the Tyrosine Phosphorylation and DNA Binding Activity of Multiple Specific STAT Family Members

1996 • 498 citations

Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway.

1994 • 454 citations

Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia.

1996 • 452 citations

A coiled-coil oligomerization domain of Bcr is essential for the transforming function of Bcr-Abl oncoproteins.

1993 • 423 citations

BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner

1991 • 375 citations

bcr-abl, the hallmark of chronic myeloid leukaemia in man, induces multiple haemopoietic neoplasms in mice.

1990 • 371 citations

Current protocols in immunology

1992 • 356 citations

Oligomerization of the ABL Tyrosine Kinase by the Ets Protein TEL in Human Leukemia

1996 • 349 citations

High-resolution crystal structures of tyrosine kinase SH3 domains complexed with proline-rich peptides

1994 • 310 citations

A quantitative assay for transformation of bone marrow cells by Abelson murine leukemia virus.

1976 • 299 citations

N-terminal mutations activate the leukemogenic potential of the myristoylated form of c-abl.

1989 • 288 citations

Activation of tyrosinase kinase and microfilament-binding functions of c-abl by bcr sequences in bcr/abl fusion proteins.

1991 • 286 citations

Bcr-Abl Efficiently Induces a Myeloproliferative Disease and Production of Excess Interleukin-3 and Granulocyte-Macrophage Colony-Stimulating Factor in Mice: A Novel Model for Chronic Myelogenous Leukemia

1998 • 284 citations

Constitutive activation of JAKs and STATs in BCR-Abl-expressing cell lines and peripheral blood cells derived from leukemic patients.

1997 • 283 citations

Structural and Signaling Requirements for BCR-ABL-Mediated Transformation and Inhibition of Apoptosis

1995 • 282 citations

The BCR gene encodes a novel serine/threonine kinase activity within a single exon

1991 • 273 citations

Alternative signals to RAS for hematopoietic transformation by the BCR-ABL oncogene

1995 • 261 citations

The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity

1997 • 258 citations

Association of the Protein Kinases c-Bcr and Bcr-Abl with Proteins of the 14-3-3 Family

1994 • 233 citations

BCR/ABL P210 and P190 cause distinct leukemia in transgenic mice

1995 • 224 citations

Deletion of an N-terminal regulatory domain of the c-abl tyrosine kinase activates its oncogenic potential.

1989 • 207 citations

The CML-Specific P210bcr/ablProtein, Unlike v-abl, Does Not Transform NIH/3T3 Fibroblasts

1987 • 181 citations

the Viral and Cellular Forms of the Abelson (Dbl) Oncogene

1988 • 157 citations

Development of Acute Lymphoblastic Leukemia and Myeloproliferative Disorder in Transgenic Mice Expressing p210bcr/abl: A Novel Transgenic Model for Human Ph1-Positive Leukemias

1998 • 131 citations

A bcr-v-abl oncogene induces lymphomas in transgenic mice.

1989 • 125 citations

Signal transduction by wild-type and leukemogenic Abl proteins

1997 • 107 citations

Bcr-Abl Efficiently Induces a Myeloproliferative Disease and Production of Excess Interleukin-3 and Granulocyte-Macrophage Colony-Stimulating Factor in Mice: A Novel Model for Chronic Myelogenous Leukemia

1998 • 95 citations

Expression of p210bcr/abl by metallothionein promoter induced T-cell leukemia in transgenic mice

1995 • 88 citations

The Human Leukemia Oncogene bcr-abl Abrogates the Anchorage Requirement but Not the Growth Factor Requirement for Proliferation

1995 • 87 citations

Regulation of the Oncogenic Activity of BCR-ABL by a Tightly Bound Substrate Protein RIN1

1997 • 84 citations

The SH3 Domain Contributes to BCR/ABL-Dependent Leukemogenesis In Vivo: Role in Adhesion, Invasion, and Homing

1998 • 77 citations

Oncogenic v-Abl tyrosine kinase can inhibit or stimulate growth, depending on the cell context.

1992 • 64 citations

Hematologic disease induced in BALB/c mice by a bcr-abl retrovirus is influenced by the infection conditions.

1992 • 63 citations

Inhibition of Bcr Serine Kinase by Tyrosine Phosphorylation

1996 • 52 citations

Effect of Bcr sequences on the cellular function of the Bcr-Abl oncoprotein

1997 • 51 citations

The SH2-containing adapter protein GRB10 interacts with BCR-ABL

1998 • 51 citations

BCR-ABL tyrosine kinase is autophosphorylated or transphosphorylates P160 BCR on tyrosine predominantly within the first BCR exon.

1993 • 48 citations

v-abl causes hematopoietic disease distinct from that caused by bcr-abl.

1991 • 46 citations

The solution structure of Abl SH3, and its relationship to SH2 in the SH(32) construct

1995 • 41 citations

Requirement of two specific tyrosine residues for the catalytic activity of Bcr serine/threonine kinase

1998 • 26 citations

ABL oncogenes directly stimulate two distinct target cells in bone marrow from 5-fluorouracil-treated mice.

1993 • 18 citations

v-abl causes hematopoietic disease distinct from that caused by bcr-abl. - eScholarship

1991 • 8 citations