Calcium Antagonists Clinical Use in the Treatment of Systemic Hypertension

Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis

1977 • 1,317 citations

Comparative pharmacology of calcium antagonists: Nifedipine, verapamil and diltiazem

1980 • 865 citations

Calcium Channel Blocking Agents in the Treatment of Cardiovascular Disorders. Part II: Hemodynamic Effects and Clinical Applications

1980 • 551 citations

Treatment of hypertension with nifedipine, a calcium antagonistic agent.

1979 • 357 citations

Nifedipine, a new antihypertensive with rapid action

1977 • 246 citations

Antihypertensive effect of cardiovascular Ca2+-antagonist in hypertensive patients in the absence and presence of beta-adrenergic blockade

1978 • 238 citations

Agonist induced release of intracellular Ca2+ in the rabbit aorta

1976 • 212 citations

Effects of intravenous verapamil on hemodynamics in patients with heart disease

1977 • 192 citations

Double-blind Evaluation of Verapamil, Propranolol, and Isosorbide Dinitrate against a Placebo in the Treatment of Angina Pectoris

1973 • 188 citations

Clinical use of a calcium antagonistic agent (nifedipine) in acute pulmonary edema

1979 • 168 citations

Short- and long-term efficacy of a calcium-antagonistic agent (nifedipine) combined with methyldopa in the treatment of severe hypertension.

1980 • 163 citations

Clinical Evaluation of Verapamil in Angina Pectoris

1968 • 152 citations

Electrophysiologic and hemodynamic effects of verapamin. Correlation with plasma drug concentrations.

1978 • 150 citations

Effect of nifedipine on plasma renin, aldosterone and catecholamines in arterial hypertension

1979 • 150 citations

Acute and chronic effects of nifedipine in arterial hypertension

1978 • 149 citations

Hypertension and Hyperparathyroidism

1972 • 146 citations

The 24-hour ambulatory blood pressure profile with verapamil.

1982 • 136 citations

Efficacy of Sublingual Nifedipine in the Acute Treatment of Systemic Hypertension

1981 • 136 citations

The treatment of hypertension with verapamil.

1978 • 130 citations

Blood Pressure Effects of Acute Hypercalcemia

1972 • 129 citations

III. CALCIUM ANTAGONISTS

1980 • 123 citations

Antihypertensive and renal effects of orally administered verapamil

1980 • 111 citations

Relationship between the antihypertensive effect and steady-state plasma concentration of nifedipine given alone or in combination with a beta-adrenoceptor blocking agent

1980 • 94 citations

Hypotensive Action and Increased Plasma Renin Activity by Ca<sup>2+</sup> Antagonist (Nifedipine) in Hypertensive Patients

1976 • 92 citations

Calcium accumulation and enzymatic activities of subcellular fractions from aortas and ventricles of genetically hypertensive rats.

1976 • 90 citations

Antihypertensive Effect of 4 (-2'-Nitrophenyl)-2, 6-Dimethyl-1, 4-Dihydropyridine-3, 5-Dicarbonic Acid Dimethylester (Nifedipine, Bay-a 1040), a New Coronary Dilator

1972 • 87 citations

Studies on a New 1, 5-Benzothiazepine Derivative (CRD-401)

1974 • 81 citations

A Study on the Effects of Nifedipine in Hypertensive Crises and Severe Hypertension

1978 • 80 citations

Intracardiac conduction defects following overdose of tricyclic antidepressant drugs.

1975 • 80 citations

Klinisch-experimentelle Untersuchungen über die blutdrucksenkende Wirkung von Verapamil

1970 • 76 citations

Effects of Extracellular Calcium on Potassium and Noradrenaline Induced Contractions in the Aorta of Spontaneously Hypertensive Rats – Increased Sensitivity to Nifedipine

1978 • 74 citations

Blood pressure in subjects with hypercalcaemia and primary hyperparathyroidism detected in a health screening programme

1977 • 74 citations

Cardiovascular actions of iproveratril.

1967 • 73 citations

Superiority of verapamil to propranolol in stable angina pectoris: a double-blind, randomized crossover trail.

1982 • 64 citations

Haemodynamic effects of intravenous verapamil at rest and during exercise in subjectively healthy middle-aged men

1975 • 61 citations

The haemodynamic effect of verapamil

1971 • 60 citations

Hemodynamic effects of verapamil and practolol in man.

1976 • 55 citations

Comparison of oral propranolol and verapamil for combined systemic hypertension and angina pectoris

1982 • 54 citations

Calcium kinetics in the aorta of spontaneously hypertensive rats

1977 • 52 citations

Antihypertensive effect of fractionated sublingual administration of nifedipine in moderate essential hypertension

1980 • 51 citations

Vasodilating Drugs: Contrasting Haemodynamic Effects

1976 • 51 citations

Acute and Chronic Effects of Nifedipine on Plasma Renin Activity and Plasma Adrenaline and Noradrenaline in Controls and Hypertensive Patients

1979 • 47 citations

The Effect of Nifedipine on Isolated Human Peripheral Vessels

1978 • 44 citations

Calcium Content of Arteriolar Walls in Normotensive and Hypertensive Rats.

1966 • 42 citations

Does verapamil have a clinically significant antihypertensive effect?

1978 • 40 citations

Treatment of severe hypertension and hypertensive emergency with nifedipine, a calcium antagonistic agent.

1981 • 39 citations

Verapamil in chronic stable angina: Amelioration of pacing-induced abnormalities of left ventricular ejection fraction, regional wall motion, lactate metabolism and hemodynamics

1981 • 38 citations

Effects of Verapamil and Nitroglycerin on Contractile Responses to Potassium and Noradrenaline in Isolated Human Peripheral Veins

1978 • 36 citations

Verapamil in the Management of Hypertensive Patients

1979 • 33 citations

Haemodynamic Effects of a Calcium Antagonistic Agent (Nifedipine) in Hypertension: Therapeutic Implications

1978 • 32 citations

Haemodynamic effects of a new anti-anginal drug, diltiazem hydrochloride.

1977 • 31 citations

Comparison of hemodynamic effects between .BETA.-blocking agents and a new antianginal agent, diltiazem hydrochloride.

1979 • 31 citations

Antihypertensive effects of nifedipine on conscious normotensive and hypertensive rats.

1981 • 28 citations

Clinical study on the hypotensive effect of diltiazem hydrochloride.

1981 • 27 citations

Renal hemodynamic and autoregulatory responses to acute hypercalcemia

1977 • 26 citations

Differential effects of calcium channel blocking agents on oxygen consumption rate in vascular smooth muscle

1982 • 26 citations

Management of severe hypertension with nifedipine in combination with clonidine or propranolol.

1980 • 25 citations

Verapamil in the management of chronic hypertension.

1980 • 25 citations

Vaso dilating drugs contrasting hemodynamic effects

1976 • 24 citations

Hemodynamic effects caused by i.v. administration of verapamil in healthy subjects.

1976 • 24 citations

Effect of calcium antagonist, nifedipine, on blood pressure of various hypertensive rats.

1980 • 18 citations

Hypotensive effects of diltiazem hydrochloride in the normotensive, spontaneously hypertensive and renal hypertensive rats

1979 • 18 citations

Action of Nitroglycerin and Amyl Nitrite in Labile and Essential Hypertension

1977 • 17 citations

Role of Haemodynamics, Catecholamines and Renin in Acute Hypercalcaemic Hypertension in Man

1980 • 16 citations

正常血圧，自然発症高血圧ならびに腎性高血圧ラットの血圧に対するDiltiazem hydrochlorideの作用

1979 • 12 citations

EFFECTS OF NIFEDIPINE ON BLOOD PRESSURE, REGIONAL HEMODYNAMICS, PLASMA RENIN ACTIVITY AND PLASMA CATECHOLAMINES IN PATIENTS WITH ARTERIAL HYPERTENSION.

1979 • 10 citations

[The treatment of renal hypertension with verapamil in childhood (author's transl].

1977 • 10 citations

Intracellular Distribution of Calcium-45 in Arteries of Normal and Hypertensive Dogs

1968 • 9 citations

The use of nifedipine as a third-step agent in the treatment of refractory hypertension.

1982 • 9 citations

Cellular Basis of Sodium-Induced Hypertension

1981 • 9 citations

Antihypertensive effect of Niludipine (Bay a 7168) on conscious renal-hypertensive dogs.

1979 • 8 citations

[On the clinical evaluation of therapy with nifedipine in association with various anithypertensive drugs (author's transl)].

1977 • 6 citations

The Inhibition of Hypertension and the Histological Changes in SHR treated with Diltiazem

1979 • 4 citations