Labelling DNA strand breaks with BrdUTP. Detection of apoptosis and cell proliferation

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

1991 • 4,682 citations

Monoclonal Antibody to 5-Bromo- and 5-Iododeoxyuridine: A New Reagent for Detection of DNA Replication

1982 • 2,648 citations

Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis

1994 • 2,450 citations

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.

1985 • 2,298 citations

Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis

1994 • 1,969 citations

Features of apoptotic cells measured by flow cytometry

1992 • 1,912 citations

Programmed cell death involved in the schizolysigenous formation of the secretory cavity in Citrus sinensis L. (Osbeck)

2010 • 1,629 citations

Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation.

1993 • 1,144 citations

Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin.

1989 • 1,030 citations

Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays.

1993 • 997 citations

Flow cytometric measurement of total DNA content and incorporated bromodeoxyuridine.

1983 • 978 citations

A new method to detect apoptosis in paraffin sections: in situ end-labeling of fragmented DNA.

1993 • 823 citations

Key morphological features of apoptosis may occur in the absence of internucleosomal DNA fragmentation

1992 • 685 citations

Analysis and discrimination of necrosis and apoptosis (programmed cell death) by multiparameter flow cytometry

1992 • 542 citations

A biochemical hallmark of apoptosis: Internucleosomal degradation of the genome

1992 • 523 citations

Internucleosomal DNA Cleavage Should not be the Sole Criterion for Identifying Apoptosis

1992 • 462 citations

Apoptosis in bone marrow biopsy samples involving stromal and hematopoietic cells in 50 patients with myelodysplastic syndromes [see comments]

1995 • 445 citations

Cell cycle dependent expression and stability of the nuclear protein detected by Ki‐67 antibody in HL‐60 cells

1992 • 368 citations

International Review of Cytology

1979 • 312 citations

Induction of DNA strand breaks associated with apoptosis during treatment of leukemias.

1993 • 292 citations

Detection of DNA fragmentation in apoptosis: application of in situ nick translation to cell culture systems and tissue sections.

1993 • 276 citations

DNA STRAND BREAKS OCCURRING DURING APOPTOSIS - THEIR EARLY INSITU DETECTION BY THE TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE AND NICK TRANSLATION ASSAYS AND PREVENTION BY SERINE PROTEASE INHIBITORS

1992 • 253 citations

Microscope‐based multiparameter laser scanning cytometer yielding data comparable to flow cytometry data

1991 • 242 citations

Single‐step procedure for labeling DNA strand breaks with fluorescein‐ or Bodipy‐conjugated deoxynucleotides: Detection of apoptosis and bromodeoxyuridine incorporation

1995 • 178 citations

Endonuclease Activities Associated with High Molecular Weight and Internucleosomal DNA Fragmentation in Apoptosis

1994 • 173 citations

Apoptosis in anititumor strategies: Modulation of cell cycle or differentiation

1995 • 138 citations

Apoptotic Cell Death During Treatment of Leukemias

1994 • 96 citations

Changes in nuclear chromatin related to apoptosis or necrosis induced by the DNA topoisomerase II inhibitor fostriecin in MOLT-4 and HL-60 cells are revealed by altered DNA sensitivity to denaturation

1992 • 88 citations

Inhibitors of proteases prevent endonucleolysis accompanying apoptotic death of HL-60 leukemic cells and normal thymocytes.

1992 • 86 citations

The concentration-dependent diversity of effects of DNA topoisomerase I and II inhibitors on the cell cycle of HL-60 cells*1

1991 • 83 citations

Further characterisation of the in situ terminal deoxynucleotidyl transferase (TdT) assay for the flow cytometric analysis of apoptosis in drug resistant and drug sensitive leukaemic cells

1995 • 64 citations

Chapter 19 Immunochemical Quantitation of Bromodeoxyuridine: Application to Cell–Cycle Kinetics

1994 • 63 citations

Simultaneous analysis of DNA replication and apoptosis during treatment of HL-60 cells with camptothecin and hyperthermia and mitogen stimulation of human lymphocytes.

1994 • 32 citations

DETECTION OF 5-BROMO-2-DEOXYURIDINE INCORPORATED INTO DNA BY LABELING STRAND BREAKS INDUCED BY PHOTOLYSIS (SBIP)

1994 • 20 citations