Vascular Endothelial Growth Factor Signaling Pathways: Therapeutic Perspective

Tumor Angiogenesis: Therapeutic Implications

1971 • 9,898 citations

The biology of VEGF and its receptors

2003 • 9,272 citations

The Biology of Vascular Endothelial Growth Factor

1997 • 4,359 citations

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

1996 • 4,143 citations

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

1995 • 3,977 citations

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

1996 • 3,664 citations

Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

1993 • 3,605 citations

Vascular Endothelial Growth Factor: Basic Science and Clinical Progress

2004 • 3,543 citations

VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche

2005 • 3,066 citations

VEGF receptor signalling ? in control of vascular function

2006 • 2,930 citations

Role of the Vascular Endothelial Growth Factor Pathway in Tumor Growth and Angiogenesis

2004 • 2,891 citations

Angiogenesis as a therapeutic target

2005 • 2,543 citations

Causes and Prevalence of Visual Impairment Among Adults in the UnitedStates

2004 • 2,541 citations

Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer

2004 • 2,481 citations

The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing

1991 • 1,991 citations

Impaired recruitment of bone-marrow–derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth

2001 • 1,874 citations

Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders.

1997 • 1,590 citations

VEGF and the quest for tumour angiogenesis factors

2002 • 1,467 citations

Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease

2006 • 1,432 citations

The Vascular Endothelial Growth Factor Family: Identification of a Fourth Molecular Species and Characterization of Alternative Splicing of RNA

1991 • 1,375 citations

Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1

1996 • 1,355 citations

Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant

1994 • 1,249 citations

Lymphangiogenesis in development and human disease

2005 • 1,225 citations

Lessons from phase III clinical trials on anti-VEGF therapy for cancer

2006 • 1,044 citations

Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis

2005 • 1,025 citations

The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions

2005 • 901 citations

MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis

2002 • 879 citations

VEGF-receptor signal transduction

2003 • 846 citations

Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3

2001 • 816 citations

A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells

2001 • 729 citations

VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism

2002 • 706 citations

Angiogenesis-Independent Endothelial Protection of Liver: Role of VEGFR-1

2003 • 658 citations

Vascular permeability factor/endothelial growth factor (VPF/VEGF): accumulation and expression in human synovial fluids and rheumatoid synovial tissue.

1994 • 524 citations

Vascular Endothelial Growth Factor Stimulates Tyrosine Phosphorylation and Recruitment to New Focal Adhesions of Focal Adhesion Kinase and Paxillin in Endothelial Cells

1997 • 477 citations

The role of VEGF receptors in angiogenesis; complex partnerships

2006 • 376 citations

Expression and function of vascular endothelial growth factor receptor-1 on human colorectal cancer cells

2005 • 333 citations

The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells

2006 • 333 citations

Suppression of ocular neovascularization with siRNA targeting VEGF receptor 1

2005 • 300 citations

VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis

2005 • 281 citations

The Adaptor Protein Shb Binds to Tyrosine 1175 in Vascular Endothelial Growth Factor (VEGF) Receptor-2 and Regulates VEGF-dependent Cellular Migration

2004 • 255 citations

Current Concepts in the Polycystic Ovary Syndrome

2001 • 244 citations

IQGAP1, a Novel Vascular Endothelial Growth Factor Receptor Binding Protein, Is Involved in Reactive Oxygen Species—Dependent Endothelial Migration and Proliferation

2004 • 233 citations

Targeting VEGF-A to Treat Cancer and Age-Related Macular Degeneration

2006 • 231 citations

Phosphorylation of tyrosine 1214 on VEGFR2 is required for VEGF-induced activation of Cdc42 upstream of SAPK2/p38

2004 • 214 citations

Angiogenic inhibitors: a new therapeutic strategy in oncology

2005 • 196 citations

The vascular endothelial growth factor receptor (VEGFR‐1) supports growth and survival of human breast carcinoma

2006 • 185 citations

A repressor sequence in the juxtamembrane domain of Flt-1 (VEGFR-1) constitutively inhibits vascular endothelial growth factor-dependent phosphatidylinositol 3′-kinase activation and endothelial cell migration

2000 • 181 citations

INTRAVITREAL INJECTION OF VASCULAR ENDOTHELIAL GROWTH FACTOR SMALL INTERFERING RNA INHIBITS GROWTH AND LEAKAGE IN A NONHUMAN PRIMATE, LASER-INDUCED MODEL OF CHOROIDAL NEOVASCULARIZATION

2004 • 171 citations

Signaling of vascular endothelial growth factor receptor-1 tyrosine kinase promotes rheumatoid arthritis through activation of monocytes/macrophages

2006 • 168 citations

GUIDELINES FOR USING VERTEPORFIN (VISUDYNE) IN PHOTODYNAMIC THERAPY FOR CHOROIDAL NEOVASCULARIZATION DUE TO AGE-RELATED MACULAR DEGENERATION AND OTHER CAUSES: UPDATE

2005 • 145 citations

Vascular endothelial growth factor receptor-1 mediates migration of human colorectal carcinoma cells by activation of Src family kinases

2006 • 123 citations

Mutation at tyrosine residue 1337 abrogates ligand-dependent transforming capacity of the FLT4 receptor.

1995 • 72 citations

Antiangiogenesis for Rheumatoid Arthritis

2005 • 37 citations

SH2 and PTB Domains in Tyrosine Kinase Signaling

2003 • 24 citations