Current Concepts in the Polycystic Ovary Syndrome

Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM).

1993 • 3,693 citations

IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

1996 • 2,561 citations

The Triumvirate: β-Cell, Muscle, Liver: A Collusion Responsible for NIDDM

1988 • 2,463 citations

Polycystic Ovary Syndrome

1995 • 2,450 citations

Insulin Resistance and the Polycystic Ovary Syndrome: Mechanism and Implications for Pathogenesis*

1997 • 2,442 citations

Profound Peripheral Insulin Resistance, Independent of Obesity, in Polycystic Ovary Syndrome

1989 • 1,858 citations

Prevalence and Predictors of Risk for Type 2 Diabetes Mellitus and Impaired Glucose Tolerance in Polycystic Ovary Syndrome: A Prospective, Controlled Study in 254 Affected Women¹

1999 • 1,571 citations

Prevalence of the Polycystic Ovary Syndrome in Unselected Black and White Women of the Southeastern United States: A Prospective Study¹

1998 • 1,550 citations

Linkage strategies for genetically complex traits. I. Multilocus models.

1990 • 1,335 citations

Glucose Transporters and Insulin Action — Implications for Insulin Resistance and Diabetes Mellitus

1999 • 1,270 citations

Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome.

1999 • 1,269 citations

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.

1999 • 1,256 citations

Insulin Resistance and the Polycystic Ovary Syndrome: Mechanism and Implications for Pathogenesis

1997 • 1,134 citations

Prevalence of the Polycystic Ovary Syndrome in Unselected Black and White Women of the Southeastern United States: A Prospective Study

1998 • 1,081 citations

A Survey of the Polycystic Ovary Syndrome in the Greek Island of Lesbos: Hormonal and Metabolic Profile

1999 • 1,033 citations

Prevalence and Predictors of Risk for Type 2 Diabetes Mellitus and Impaired Glucose Tolerance in Polycystic Ovary Syndrome: A Prospective, Controlled Study in 254 Affected Women

1999 • 1,022 citations

POLYCYSTIC OVARIES—A COMMON FINDING IN NORMAL WOMEN

1988 • 926 citations

Correlation of Hyperandrogenism with Hyperinsulinism in Polycystic Ovarian Disease*

1980 • 910 citations

Linkage strategies for genetically complex traits. II. The power of affected relative pairs.

1990 • 886 citations

Protein–protein interaction in insulin signaling and the molecular mechanisms of insulin resistance

1999 • 867 citations

Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia, and systolic blood pressure, while facilitating normal menses and pregnancy

1994 • 854 citations

Insulin Action and the Insulin Signaling Network*

1995 • 823 citations

Effects of Metformin on Spontaneous and Clomiphene-Induced Ovulation in the Polycystic Ovary Syndrome

1998 • 795 citations

Decreases in Ovarian Cytochrome P450c17α Activity and Serum Free Testosterone after Reduction of Insulin Secretion in Polycystic Ovary Syndrome

1996 • 745 citations

Evidence for a genetic basis for hyperandrogenemia in polycystic ovary syndrome

1998 • 689 citations

Characterization of Groups of Hyperaiidrogenic Women with Acanthosis Nigricans, Impaired Glucose Tolerance, and/or Hyperinsulinemia*

1987 • 590 citations

Insulin Stimulates Testosterone Biosynthesis by Human Thecal Cells from Women with Polycystic Ovary Syndrome by Activating Its Own Receptor and Using Inositolglycan Mediators as the Signal Transduction System¹

1998 • 571 citations

Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome.

1995 • 549 citations

The insulin-sensitizing agent troglitazone improves metabolic and reproductive abnormalities in the polycystic ovary syndrome.

1996 • 538 citations

Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects.

1995 • 524 citations

Evidence for Distinctive and Intrinsic Defects in Insulin Action in Polycystic Ovary Syndrome

1992 • 511 citations

Polycystic Ovary Syndrome as a Form of FunctionalOvarian Hyperandrogenism Due to Dysregulation ofAndrogen Secretion*

1995 • 508 citations

Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome

1989 • 505 citations

Ovulatory and Metabolic Effects of d-Chiro-Inositol in the Polycystic Ovary Syndrome

1999 • 497 citations

Augmented Androgen Production Is a Stable Steroidogenic Phenotype of Propagated Theca Cells from Polycystic Ovaries

1999 • 491 citations

Thirty-seven candidate genes for polycystic ovary syndrome: Strongest evidence for linkage is with follistatin

1999 • 483 citations

Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes

1999 • 483 citations

Insulin secretory defects in polycystic ovary syndrome. Relationship to insulin sensitivity and family history of non-insulin-dependent diabetes mellitus.

1995 • 435 citations

Epidemiology of infertility and polycystic ovarian disease: endocrinological and demographic studies

1987 • 428 citations

Beta-cell dysfunction independent of obesity and glucose intolerance in the polycystic ovary syndrome.

1996 • 423 citations

Hypersecretion of androstenedione by isolated thecal cells from polycystic ovaries.

1994 • 404 citations

Hyperfunction of the Hypothalamic-Pituitary Axis in Women with Polycystic Ovarian Disease: Indirect Evidence for Partial Gonadotroph Desensitization*

1988 • 398 citations

Insulin Stimulates Testosterone Biosynthesis by Human Thecal Cells from Women with Polycystic Ovary Syndrome by Activating Its Own Receptor and Using Inositolglycan Mediators as the Signal Transduction System

1998 • 392 citations

Polycystic ovary syndrome as a form of functional ovarian hyperandrogenism due to dysregulation of androgen secretion

1995 • 386 citations

Characterization of signal transduction and glucose transport in skeletal muscle from type 2 diabetic patients.

2000 • 374 citations

The IRS-Signaling System: A Network of Docking Proteins That Mediate Insulin and Cytokine Action

1998 • 369 citations

Induction of insulin resistance by androgens and estrogens.

1994 • 366 citations

The Polycystic Ovary. I. Clinical and Histologic Features

1962 • 366 citations

Insulin Receptor Substrate-1 Phosphorylation and Phosphatidylinositol 3-Kinase Activity in Skeletal Muscle From NIDDM Subjects After In Vivo Insulin Stimulation

1997 • 347 citations

Suppression of Serum Insulin by Diazoxide Reduces Serum Testosterone Levels in Obese Women with Polycystic Ovary Syndrome*

1989 • 345 citations

Defects in insulin receptor signaling in vivo in the polycystic ovary syndrome (PCOS)

2001 • 327 citations

Cellular mechanisms of insulin resistance in polycystic ovarian syndrome.

1992 • 325 citations

Membrane glycoprotein PC-1 and insulin resistance in non-insulin-dependent diabetes mellitus

1995 • 312 citations

Human Molecular Genetics

2018 • 312 citations

A Survey of the Polycystic Ovary Syndrome in the Greek Island of Lesbos: Hormonal and Metabolic Profile

1999 • 305 citations

Mutations in the Insulin Receptor Gene

1992 • 294 citations

The genetic basis of polycystic ovary syndrome

1997 • 293 citations

New Insights Into the Role and Mechanism of Glycogen Synthase Activation by Insulin

1997 • 293 citations

Evidence for a single gene effect causing polycystic ovaries and male pattern baldness

1993 • 288 citations

The relationship of insulin insensitivity to menstrual pattern in women with hyperandrogenism and polycystic ovaries

1993 • 287 citations

Insulin-like growth factors and insulin: comparative aspects

1985 • 262 citations

INSULIN ACTION IN THE NORMAL AND POLYCYSTIC OVARY

1999 • 256 citations

Impaired glucose transport and insulin receptor tyrosine phosphorylation in skeletal muscle from obese women with gestational diabetes.

1999 • 249 citations

The insulin resistance in women with hyperandrogenism is partially reversed by antiandrogen treatment: evidence that androgens impair insulin action in women.

1996 • 230 citations

The insulin-sensitizing agent troglitazone improves metabolic and reproductive abnormalities in the polycystic ovary syndrome

1996 • 228 citations

Defects in beta-cell function in functional ovarian hyperandrogenism.

1993 • 225 citations

Serum lipoprotein lipid profile in women with the polycystic ovary syndrome: relation to anthropometric, endocrine and metabolic variables

1994 • 221 citations

Insulin action and the insulin signaling network

1995 • 216 citations

Insulin administration alters gonadal steroid metabolism independent of changes in gonadotropin secretion in insulin-resistant women with the polycystic ovary syndrome.

1989 • 200 citations

Insulin action in human granulosa cells from normal and polycystic ovaries is mediated by the insulin receptor and not the type-I insulin-like growth factor receptor.

1995 • 198 citations

Dyslipidaemia is associated with insulin resistance in women with polycystic ovaries

1996 • 183 citations

INSULIN ACTION IN THE POLYCYSTIC OVARY SYNDROME

1999 • 183 citations

Evidence for the Importance of Peripheral Tissue Events in the Development of Hirsutism in Polycystic Ovary Syndrome*

1983 • 183 citations

Insulin infusion amplifies 17 alpha-hydroxycorticosteroid intermediates response to adrenocorticotropin in hyperandrogenic women: apparent relative impairment of 17,20-lyase activity.

1996 • 182 citations

Selective Insulin Resistance in the Polycystic Ovary Syndrome¹

1999 • 176 citations

Insulin Stimulates Androgen Accumulation in Incubations of Human Ovarian Stroma and Theca

1984 • 174 citations

Timing of Prenatal Androgen Excess Determines Differential Impairment in Insulin Secretion and Action in Adult Female Rhesus Monkeys1

2000 • 171 citations

Prenatal exposure of female rhesus monkeys to testosterone propionate increases serum luteinizing hormone levels in adulthood

1997 • 161 citations

Phenotype and genotype in polycystic ovary syndrome

2001 • 149 citations

Beta-cell dysfunction independent of obesity and glucose intolerance in the polycystic ovary syndrome

1996 • 148 citations

Evidence for distinctive and intrinsic defects in insulin action in polycystic ovary syndrome

1992 • 142 citations

A Chronobiologic Abnormality in Luteinizing Hormone Secretion in Teenage Girls with the Polycystic-Ovary Syndrome

1983 • 141 citations

Hypersecretion of androstenedione by isolated thecal cells from polycystic ovaries

1994 • 139 citations

NEUROENDOCRINE ASPECTS OF POLYCYSTIC OVARY SYNDROME

1999 • 124 citations

Central Role of the Adipocyte in Insulin Resistance

1998 • 122 citations

Augmented Androgen Production Is a Stable Steroidogenic Phenotype of Propagated Theca Cells from Polycystic Ovaries

1999 • 118 citations

Molecular scanning of the insulin receptor gene in women with polycystic ovarian syndrome.

1996 • 117 citations

Selective Insulin Resistance in the Polycystic Ovary Syndrome

1999 • 114 citations

Induction of insulin resistance by androgens and estrogens

1994 • 112 citations

Insulin Receptor Substrate-2 Is Not Necessary for Insulin- and Exercise-stimulated Glucose Transport in Skeletal Muscle

1999 • 106 citations

Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation

1997 • 97 citations

Cellular Insulin Resistance in Adipocytes from Obese Polycystic Ovary Syndrome Subjects Involves Adenosine Modulation of Insulin Sensitivity¹

1997 • 93 citations

Cellular mechanisms of insulin resistance in polycystic ovarian syndrome

1992 • 87 citations

The outcome of in-vitro fertilization treatment in women with sonographic evidence of polycystic ovarian morphology

1999 • 86 citations

Allelic Variants of the Follistatin Gene in Polycystic Ovary Syndrome¹

2000 • 84 citations

Defects in beta-cell function in functional ovarian hyperandrogenism

1993 • 83 citations

The insulin resistance in women with hyperandrogenism is partially reversed by antiandrogen treatment: evidence that androgens impair insulin action in women

1996 • 72 citations

New insights into the role and mechanism of glycogen synthase activation by insulin

1997 • 71 citations

Genetics: The tyrosine kinase domain of the insulin receptor gene is normal in women with hyperinsulinaemia and polycystic ovary syndrome

1994 • 70 citations

Severe impairment of insulin action in adipocytes from amenorrheic subjects with polycystic ovary syndrome

1994 • 67 citations

Prevalence of polycystic ovary syndrome in women seeking treatment from community electrologists. Alabama Professional Electrology Association Study Group.

1999 • 66 citations

Absence of insulin receptor gene mutations in three insulin-resistant women with the polycystic ovary syndrome

1994 • 66 citations

Cellular Insulin Resistance in Adipocytes from Obese Polycystic Ovary Syndrome Subjects Involves Adenosine Modulation of Insulin Sensitivity

1997 • 65 citations

Insulin infusion amplifies 17 alpha-hydroxycorticosteroid intermediates response to adrenocorticotropin in hyperandrogenic women: apparent relative impairment of 17,20-lyase activity

1996 • 65 citations

Insulin action in human granulosa cells from normal and polycystic ovaries is mediated by the insulin receptor and not the type-I insulin- like growth factor receptor

1995 • 63 citations

Timing of Prenatal Androgen Excess Determines Differential Impairment in Insulin Secretion and Action in Adult Female Rhesus Monkeys

2000 • 59 citations

Insulin signaling in insulin receptor substrate (IRS)-1-deficient brown adipocytes: requirement of IRS-1 for lipid synthesis.

1999 • 55 citations

Molecular scanning of the insulin receptor gene in women with polycystic ovarian syndrome

1996 • 53 citations

Suppression of serum insulin level by diazoxide does not alter serum testosterone or sex hormone-binding globulin levels in healthy, nonobese women

1990 • 52 citations

Decreases in Ovarian Cytochrome P450c17 alpha Activity and Serum Free Testosterone After Reduction of Insulin Secretion in Polycystic Ovary Syndrome

1997 • 51 citations

Hyperinsulinemia is associated with menstrual irregularity and altered serum androgens in Pima Indian women

1994 • 48 citations

Toward an Integrated Phenotype in Pre‐NIDDM

1996 • 36 citations

Mutations in the insulin receptor gene

1992 • 35 citations

Lack of insulin resistance in fibroblasts from subjects with polycystic ovary syndrome

1998 • 30 citations

Changing Pituitary Reactivity to Follicle-Stimulating Hormone and Luteinizing Hormone-Releasing Hormone After Induced Ovulatory Cycles and After Anovulation in Patients With Polycystic Ovarian Disease

1987 • 26 citations