Vascular endothelial growth factor receptor-1 mediates migration of human colorectal carcinoma cells by activation of Src family kinases

Bevacizumab plus Irinotecan, Fluorouracil, and Leucovorin for Metastatic Colorectal Cancer

2004 • 10,779 citations

Vascular Endothelial Growth Factor Is a Secreted Angiogenic Mitogen

1989 • 4,988 citations

Vascular endothelial growth factor (VEGF) and its receptors

1999 • 3,498 citations

CELLULAR FUNCTIONS REGULATED BY SRC FAMILY KINASES

1997 • 2,470 citations

High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis

1993 • 1,961 citations

Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor.

1994 • 1,661 citations

Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions

2001 • 1,640 citations

Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1

1996 • 1,355 citations

Regulation, substrates and functions of src

1996 • 1,173 citations

Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice

1998 • 1,077 citations

Selective Requirement for Src Kinases during VEGF-Induced Angiogenesis and Vascular Permeability

1999 • 802 citations

Src family kinases in tumor progression and metastasis.

2003 • 787 citations

Expression of vascular endothelial growth factor and its receptors in hematopoietic malignancies.

1999 • 543 citations

Autocrine stimulation of VEGFR-2 activates human leukemic cell growth and migration

2000 • 435 citations

Congenital Hereditary Lymphedema Caused by a Mutation That Inactivates VEGFR3 Tyrosine Kinase

2000 • 415 citations

Increase in activity and level of pp60c-src in progressive stages of human colorectal cancer.

1993 • 396 citations

Involvement of Flt-1 tyrosine kinase (vascular endothelial growth factor receptor-1) in pathological angiogenesis.

2001 • 345 citations

Vascular endothelial growth factor (VEGF) is an autocrine growth factor for VEGF receptor–positive human tumors

2001 • 343 citations

Vessel Counts and Expression of Vascular Endothelial Growth Factor as Prognostic Factors in Node-Negative Colon Cancer

1997 • 333 citations

Expression and function of vascular endothelial growth factor receptor-1 on human colorectal cancer cells

2005 • 333 citations

Inhibition of both paracrine and autocrine VEGF/ VEGFR-2 signaling pathways is essential to induce long-term remission of xenotransplanted human leukemias

2001 • 275 citations

pp60c-src activation in human colon carcinoma.

1989 • 267 citations

Activation of Src kinase in primary colorectal carcinoma

2002 • 249 citations

Identification of Src-Specific Phosphorylation Site on Focal Adhesion Kinase: Dissection of the Role of Src SH2 and Catalytic Functions and Their Consequences for Tumor Cell Behavior

2005 • 213 citations

Src activation regulates anoikis in human colon tumor cell lines

2002 • 210 citations

The effects of angiopoietin-1 and -2 on tumor growth and angiogenesis in human colon cancer.

2001 • 210 citations

Down-regulation of Vascular Endothelial Growth Factor in a Human Colon Carcinoma Cell Line Transfected with an Antisense Expression Vector Specific for c-src

1998 • 204 citations

Expression of vascular endothelial growth factor receptors in human prostate cancer

1999 • 202 citations

Inhibition of wild-type and mutant Bcr-Abl by AP23464, a potent ATP-based oncogenic protein kinase inhibitor: implications for CML

2004 • 196 citations

Expression of vascular endothelial growth factor (VEGF) and its two receptors (VEGF‐R1‐Flt1 and VEGF‐R2‐Flk1/KDR) in non‐small cell lung carcinomas (NSCLCs): correlation with angiogenesis and survival

1999 • 177 citations

Human Melanoma Cells Secrete and Respond to Placenta Growth Factor and Vascular Endothelial Growth Factor

2000 • 171 citations

Targeting autocrine and paracrine VEGF receptor pathways inhibits human lymphoma xenografts in vivo

2004 • 124 citations

c-Yes tyrosine kinase activity in human colon carcinoma.

1993 • 108 citations

Src kinase becomes preferentially associated with the VEGFR, KDR/Flk-1, following VEGF stimulation of vascular endothelial cells.

2002 • 97 citations

Soluble vascular endothelial growth factor levels in patients with primary colorectal carcinoma

2000 • 87 citations

AP23846, a novel and highly potent Src family kinase inhibitor, reduces vascular endothelial growth factor and interleukin-8 expression in human solid tumor cell lines and abrogates downstream angiogenic processes

2005 • 79 citations

The guanine nucleotide exchange factor Tiam1 increases colon carcinoma growth at metastatic sites in an orthotopic nude mouse model

2005 • 70 citations

In vitro and in vivo activity of ATP-based kinase inhibitors AP23464 and AP23848 against activation-loop mutants of Kit

2005 • 61 citations

FGF signaling activates STAT1 and p21 and inhibits the estrogen response and proliferation of MCF-7 cells

1998 • 59 citations

c-Src Mediates Mitogenic Signals and Associates with Cytoskeletal Proteins upon Vascular Endothelial Growth Factor Stimulation in Kaposi’s Sarcoma Cells

2000 • 43 citations

Comparative Structure‐Function Analysis of VEGFR‐1 and VEGFR‐2

2003 • 39 citations

Vascular endothelial growth factor and cellular chemotaxis: a possible autocrine pathway in adult T-cell leukemia cell invasion.

2001 • 35 citations

The tubulogenic activity associated with an activated form of Flt-1 kinase is dependent on focal adhesion kinase

2001 • 17 citations

Antitumor effects of synthetic VEGF-receptor binding antagonist, VGA1155.

2005 • 8 citations