Active T-Cell Receptor Genes Have Intron Deoxyribonuclease Hypersensitive Sites

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Chromosomal Subunits in Active Genes Have an Altered Conformation

1976 • 1,842 citations

A better cell line for making hybridomas secreting specific antibodies

1978 • 1,649 citations

A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes

1983 • 1,449 citations

A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene

1983 • 1,418 citations

A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains

1984 • 1,262 citations

Isolation of cDNA clones encoding T cell-specific membrane-associated proteins

1984 • 1,239 citations

Changes in size and secondary structure of the ribosomal transcription unit during vertebrate evolution

1975 • 1,188 citations

[18] Hybridization of denatured RNA transferred or dotted to nitrocellulose paper

1983 • 1,112 citations

B Lineage—Specific Interactions of an Immunoglobulin Enhancer with Cellular Factors in Vivo

1985 • 859 citations

Immunoglobulin gene transcription is activated by downstream sequence elements

1983 • 830 citations

Sequence relationships between putative T-cell receptor polypeptides and immunoglobulins

1984 • 719 citations

Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences

1984 • 652 citations

A drosophila RNA polymerase II transcription factor binds to the regulatory site of an hsp 70 gene

1984 • 534 citations

Selective digestion of transcriptionally active ovalbumin genes from oviduct nuclei.

1976 • 523 citations

Negatively supercoiled simian virus 40 DNA contains Z-DNA segments within transcriptional enhancer sequences

1983 • 474 citations

Somatic recombination in a murine T-cell receptor gene

1984 • 468 citations

Expression and regulation of immunoglobulin heavy chain gene transfected into lymphoid cells.

1983 • 457 citations

An altered DNA conformation detected by S1 nuclease occurs at specific regions in active chick globin chromatin

1982 • 448 citations

The chromatin structure of specific genes: I. Evidence for higher order domains of defined DNA sequence

1979 • 445 citations

Chromatin structure and protein binding in the putative regulatory region of the c-myc gene in burkitt lymphoma

1984 • 443 citations

A lymphocyte-specific enhancer in the mouse immunoglobulin κ gene

1984 • 410 citations

Mouse T cell antigen receptor: Structure and organization of constant and joining gene segments encoding the β polypeptide

1984 • 407 citations

Murine B Cell Leukemia Line with Inducible Surface Immunoglobulin Expression

1978 • 388 citations

Genomic organization and sequence of T-cell receptor β-chain constant- and joining-region genes

1984 • 377 citations

Temporal order of chromatin structural changes associated with activation of the major chicken vitellogenin gene

1983 • 366 citations

Cell-type-specific contacts to immunoglobulin enhancers in nuclei

1985 • 341 citations

Activating protein factor binds in vitro to upstream control sequences in heat shock gene chromatin

1984 • 329 citations

Identification of D segments of immunoglobulin heavy-chain genes and their rearrangement in T lymphocytes

1981 • 327 citations

The human t cell antigen receptor is encoded by variable, diversity, and joining gene segments that rearrange to generate a complete V gene

1984 • 306 citations

Studies in Antibody Response of Mice to Tumour Inoculation

1950 • 298 citations

A dominant role for DNA secondary structure in forming hypersensitive structures in chromatin

1983 • 273 citations

The regulation of yeast mating-type chromatin structure by SIR: An action at a distance affecting both transcription and transposition

1982 • 257 citations

Specific factor conferring nuclease hypersensitivity at the 5' end of the chicken adult beta-globin gene.

1984 • 249 citations

Progressive Loss of H-2 Antigens With Concomitant Increase of Cell-Surface Antigen(s) Determined by Moloney Leukemia Virus in Cultured Murine Lymphomas23

1973 • 239 citations

Multiple Immunoglobulin Heavy-Chain Gene Transcripts in Abelson Murine Leukemia Virus-Transformed Lymphoid Cell Lines

1982 • 228 citations

Induction of altered chromatin structures by simian virus 40 enhancer and promoter elements

1984 • 217 citations

A transposable element inserted just 5′ to a Drosophila glue protein gene alters gene expression and chromatin structure

1983 • 213 citations

Hb switching in chickens

1980 • 189 citations

Propagation of globin DNAase i-hypersensitive sites in absence of factors required for induction: A possible mechanism for determination

1982 • 189 citations

Rearrangement and transcription of the β-chain genes of the T-cell antigen receptor in different types of murine lymphocytes

1985 • 172 citations

Association of an S1 nuclease-sensitive structure with short direct repeats 5′ of Drosophila heat shock genes

1983 • 171 citations

Expression of the immunoglobulin C mu gene in mouse T and B lymphoid and myeloid cell lines.

1980 • 170 citations

An expandable gene that encodes a Drosophila glue protein is not expressed in variants lacking remote upstream sequences

1982 • 165 citations

A conserved sequence in the immunoglobulin Jκ–Cκ intron: possible enhancer element

1983 • 162 citations

Transcriptional Enhancer Elements in the Mouse Immunoglobulin Heavy Chain Locus

1983 • 160 citations

Localization of a T-cell receptor diversity-region element

1984 • 159 citations

Immunoglobulin messenger RNAs in murine cell lines that have characteristics of immature B lymphocytes

1979 • 158 citations

Fine mapping of an immunoglobulin gene activator.

1984 • 144 citations

Genes transcribed at diverse rates have a similar conformation in chromatin

1977 • 140 citations

Chromatin changes accompany immunoglobulin κ gene activation: a potential control region within the gene

1982 • 138 citations

Alternative sets of DNase I-hypersensitive sites characterize the various functional states of the chicken lysozyme gene

1984 • 136 citations

A complex of interacting DNAase I-hypersensitive sites near the drosophila glue protein gene, Sgs4

1982 • 126 citations

Production of autoreactive I region-restricted T cell hybridomas.

1982 • 122 citations

Molecular biology: Anatomy of hypersensitive sites

1984 • 119 citations

Cell receptors for the mammalian reovirus. I. Syngeneic monoclonal anti-idiotypic antibody identifies a cell surface receptor for reovirus.

1983 • 114 citations

DNase I hypersensitive sites in the chromatin of human μ immunoglobulin heavy-chain genes

1983 • 110 citations

Methylation status and DNase I sensitivity of immunoglobulin genes: changes associated with rearrangement.

1983 • 102 citations

Somatic rearrangements forming active immunoglobulin mu genes in B and T lymphoid cell lines.

1980 • 101 citations

Alteration of c-myc chromatin structure by avian leukosis virus integration

1984 • 94 citations

Structure of a nuclease-sensitive region inside the immunoglobin kappa gene: evidence for a role in gene regulation

1983 • 92 citations

Transcripts of the immunoglobulin C mu gene vary in structure and splicing during lymphoid development.

1980 • 89 citations

Rearranged and germline immunoglobulin .kappa. genes: different states of DNase I sensitivity of C.kappa. genes in immunocompetent and nonimmune cells

1981 • 88 citations

Partial Purification and Molecular Characterization of a Lymphokine (Costimulator) Required for the Mitogenic Response of Mouse Thymocytes in Vitro

1978 • 86 citations

Genetic control of radiation leukemia virus-induced tumorigenesis. I. Role of the major murine histocompatibility complex, H-2.

1977 • 74 citations

Helper and killer T cells do not express B cell immunoglobulin joining and constant region gene segments.

1980 • 73 citations

An immunoglobulin heavy-chain gene is altered in two T-cell clones

1980 • 72 citations

DNA sequence changes in an upstream DNase I-hypersensitive region are correlated with reduced gene expression.

1983 • 71 citations

DNase I-hypersensitive sites in the chromatin of immunoglobulin kappa light chain genes.

1983 • 70 citations

Serological Analysis of Cell Surface Antigens of Tumors Induced by Murine Leukemia Virus

1972 • 69 citations

Lipopolysaccharide-induced transcription of the kappa immunoglobulin locus occurs on both alleles and is independent of methylatlon status

1984 • 65 citations

Immunoglobulin heavy chain gene rearrangement and transcription in murine T cell hybrids and T lymphomas.

1982 • 62 citations

The immunoglobulin μ constant region gene is expressed in mouse thymocytes

1980 • 58 citations

Organization and Expression of Murine Immunoglobulin Genes

1981 • 48 citations

Differences in the nuclease sensitivity between the two alleles of the immunoglobulin kappa light chain genes in mouse liver and myeloma nuclei

1982 • 47 citations

Induction and regulation of immunoglobulin expression in a murine pre-B cell line, 70Z/3. I. Cell cycle-associated induction of sIgM expression and kappa-chain synthesis in 70Z/3 cells by LPS stimulation.

1980 • 44 citations

The switch region associated with immunoglobulin Cμ genes is DNase I hypersensitive in T lymphocytes

1981 • 36 citations

Monoclonal AKR/J thymic leukemias contain multiple JH immunoglobulin gene rearrangements.

1983 • 30 citations

Expression of an antigen receptor on T cells does not require recombination at the immunoglobulin JH-C mu locus.

1981 • 25 citations

SEPARATION OF VIABLE FROM NONVIABLE TUMOR CELLS BY FLOTATION ON A FICOLL-TRIOSIL MIXTURE

1973 • 16 citations

CT hybridomas: tumor cells capable of lysing virally infected target cells.

1982 • 8 citations

Immunoglobulin .mu.- and .gamma.-ribonucleic acid sequences in thymocytes and splenocytes from normal and hyperimmune mice

1981 • 5 citations